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Title:: Study of heparin stability on heparincoated circuits under simulating cardiopulmonary bypass

作者:: 杨春¹; 杨剑¹; 罗鹏¹; 曹瑞军²; 周华²; (1.第四军医大学西京医院心血管外科，陕西西安 710032；2.西安交通大学应用化学系，陕西西安 710049)

Author(s):: YANG Chun¹; YANG Jian¹; LUO Peng¹; CAO Rui jun²; ZHOU Hua²; (1.Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China; 2.Deptartment of Applied Chemistry, Xi’an Jiaotong University, Xi’an 710049, Shaanxi, China)

关键词:: 肝素涂层管道; 脱落率测定; 肝素稳定性

Keywords:: heparincoated circuits; heparin offrates; heparin stability

分类号:: R608

DOI:: -

文献标识码:: A

摘要:: 目的:评估肝素涂层体外循环管道肝素的稳定性。方法：测定肝素图层体外循环管道模拟体外循环法与浸泡法在不同时点的肝素脱落率。结果：在128 h内，两组肝素结合表面均有不同程度的肝素分子脱落现象，肝素脱落率随时间增大，在一定时间内浸泡法结合的肝素表面的肝素最大脱落率为85%，而体外循环法结合表面的肝素脱落率为92%。体外循环组涂层表面中肝素的脱落率与浸泡组两者之间无显著差异。结论：短期内肝素结合体外循环管道比较牢固，满足临床使用。

Abstract:: AIM:To evaluate heparin stability on heparincoated cardiopulmonary bypass (CPB) circuits. METHODS: Heparin offrates of CPB stimulation method and immersion method at different time points were determined. RESULTS: At 128 h, different levels of heparin molecule shedding phenomenon were observed in heparinbinding surface in both groups and the heparin offrate increased with time. The maximum heparin offrates of the CPB method and immersion method were, respectively, 92 and 85 during a certain period of time, with no significant difference between groups. CONCLUSION: Heparin stability on heparincoated circuits of CPB has relatively stronger heparin binding and is of better clinical use.

参考文献/References

[1]杨剑，易定华，段维勋，等.聚乙烯亚胺-肝素结合医用聚氯乙烯材料的肝素释放速率研究[J].中国体外循环杂志,2007,5(4):241-243.
[2]杨剑，易定华，刘金成. 肝素涂层体外循环管道的制备及生物学性能评价[J].中国生物医学工程学报,2004,5(2):169-174.
[3]杨剑，段维勋，徐学增，等.肝素结合改良医用聚氯乙烯材料的细胞毒性评价[J].北京生物医学工程,2008,27(1):23-27.
[4]杨剑，易定华，刘金成，等.肝素涂层医用聚氯乙烯的细胞毒性研究[J].生物医学工程学杂志,2005,13(4):11-13.
[5]杨春，杨剑，易定华，等.肝素涂层体外循环管道中聚乙烯亚胺的作用研究[J].心脏杂志,2010,22(6):670-672.
[6]杨剑，易定华，钟丽辉，等.肝素涂层体外循环管道抗凝血性能的研究[J].生物医学工程与临床,2003,2(2):100-103.

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模拟体外循环下肝素涂层的稳定性实验

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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