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Title:: Role of KLF2 in atherosclerosis under hypoxia

作者:: 卢东东综述; 周白丽审校; (青海省人民医院心内科，青海西宁 810007)

Author(s):: LU Dong dong; ZHOU Bai li; (Department of Cardiology, Qinghai Provincial People’s Hospital, Xining 810001, Qinghai, China)

关键词:: 低氧; 锌指样转录因子2; 动脉粥样硬化

Keywords:: Kruppellike factor 2; atherosclerosis; hypoxia

分类号:: R543.5

DOI:: -

文献标识码:: A

摘要:: 锌指样转录因子2(kruppellike factor 2，KLF2)是迄今为止发现的17个锌指转录因子亚家族中的一员。近年来关于KLF2在心血管系统中作用的研究日益增多，主要因为KLF2具有抗炎、抗增殖、抗氧化等作用。动脉粥样硬化（AS）是多种因子参与的一个连续过程，是多种因素共同作用的结果。在低氧环境下，AS斑块的稳定性、参与AS的炎症因子，以及炎症因子对AS的调节作用等均不同于常氧条件下。本文就近年来国内外对KLF2抗AS作用的研究及其作用机制加以综述。

Abstract:: Kruppellike factor 2 (KLF2) is a member of the 17 zincfinger family of transcription factors. In recent years, research on KLF2 in the cardiovascular system is increasing. KLF2 plays some important roles such as antiinflammation, proliferation and antioxidant action. Atherosclerosis (AS) is a continuous, multifactorial process and is the result of the coaction of various factors. The hypoxic environment is different from the normoxic environment in accordance with stability of atheromatous plaques, participation of inflammatory factors and regulation of the action of factors on AS. This paper summarizes research on the antiAS action of KLF and its mechanism during recent years.

参考文献/References

[1]Atkins GB,Jain MK.Role of Kruppellike transcription factors in endothelial biology[J].Circ Res, 2007,100(12):1686-1695.
[2]吕云辉.何忠明.急性低氧及高二氧化碳刺激对阻塞性睡眠呼吸暂停低通气综合征患者外周动脉硬度及血压的影响[J].中华结核和呼吸杂志,2009,32(1):42-45.
[3]Lee HY,Youn SW,Cho HJ,et al.FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Kruppellike factor 2[J].Cardiovasc Res,2013,97(1):143-152.
[4]Cullingford TE,Butler MJ,Marshall AK,et al.Differential regulation of Kruppellike factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelial，oxidative stress and cytokines[J].Biochim Biophys Aeta,2008,1783(6):1229-1236.
[5]Rhee WJ,Ni CW,Zheng Z,et al.HuR regulates the expression of stresssensitive genes and mediates inflammatory response in human umbilical vein endothelial cells[J].Proc Natl Acad Sci U S A,2010,107(15):6858-6863.
[6]Lucitti JL,Jones EA,Huang C,et al.Vascular remodeling of the mouse yolk sac requires hemodynamic force[J].Development,2007,134(8):3317-3326.
[7]MontielManzano G,RomayPenabad Z,Papalardo de martinez E,et al.In vivo effects of an inhibitor of nuclear factorkappa B on thrombogenic properties of antiphospholipid antibodies[J].Ann N Y Acad Sci,2007,1108:540-553.
[8]Zahlten J,Steinieke R,Opitz B,et al.TLR2 and nucleotidebinding oligomerization domain 2dependent Kruppellike factor 2 expressions down regulate NFkappa Brelated gene expression[J].J lmmunol,2010,185(1):597-604.
[9]Cai H,Ren Y,Li XX,et al.Scrotal heat stress causes a transient alteration in tight junctions and induction of TGFβ expression[J].Int J Androl,2011,34(4):352-362.
[10]Niemantsverdriet M,de Jong E,Langendijk JA,et al.Synergistic induction of pmfibrotic PAl-1 by TGFbeta and radiation depends on p53[J]. Radiother Oncol,2010,97(1):33-35.
[11]Ma J,Wang Q,Fei T,et al.MCP-1 mediates TGFbeta induced angiogenesis by stimulating vascular smooth muscle cell migration[J].Blood,2007,109(3):987-994.
[12]Boon RA,Horrevoets AJ.Key transcriptional regulators of the vasoprotective effects of shear sⅡess[J].Hamqstaseologie,2009,29(1):39-40，41-43.
[13]Hashmi S,Zhang J,Siddiqui SS,et al.Partner in fat metabolism: role of KLFs in fat burning and reproductive behavior[J].Biotech, 2011,1(2):59-72.
[14]周晓斌,杨丽霞.锌指样转录因子2与动脉粥样硬化[J].心血管病学进展,2012,3(33):244-246.
[15]Gotsman I,Sharpe AH,Liehtman AH.Tcell stimulation and inhibition in atherosclerosis[J].Cire Res,2008,103(11):1220-1231.
[16]张司兰,谭朝阳.低压缺氧对兔动脉粥样硬化斑块中HIF-1α、VEGF及MMP-9表达的影响[J].重庆医学,2011,40(6):542-544.

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低氧条件下Klf2在动脉粥样硬化中的作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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