我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

糖尿病心肌病发病机制的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第5期
页码:
603-605
栏目:
综述
出版日期:
2013-09-25

文章信息/Info

Title:
Research progress in the pathogenesis of diabetic cardiomyopathy
作者:
罗南方 综述; 李建美 审校
(云南省第二人民医院心内科，云南 昆明 650021)
Author(s):
LUO Nan fang;  LI Jian mei
(Department of Cardiology, Yunnan Second People’s Hospital, Kunming 650021, Yunnan, China)
关键词:
糖尿病心肌病; 发病机制; 代谢紊乱; 心肌纤维化
Keywords:
diabetic cardiomyopathy;  pathogenesis;  metabolic disorders;  myocardial fibrosis
分类号:
R587.2
DOI:
-
文献标识码:
A
摘要:
糖尿病的发病率和患病率在全世界范围不断上升。糖尿病心肌病（DCM）是糖尿病主要的心脏并发症之一，其特征为左室舒张和（或）收缩功能障碍，也可伴有心力衰竭、心律失常、心源性休克，重症患者甚至猝死。DCM的发病机制尚未完全明确，目前认为其与心肌细胞的糖代谢、脂代谢与能量代谢异常，以及心肌纤维化、氧化应激和细胞死亡等多种因素有关。本文将从细胞、组织、分子水平等方面对DCM的发病机制的研究现状做一综述，以为临床防治提供依据。
Abstract:
The prevalence and incidence rates of diabetes are continuously on the rise worldwide. Diabetic cardiomyopathy (DCM) is one of the major cardiac complications of diabetes, often indicated by left ventricular diastolic or systolic dysfunction and possibly associated with heart failure, arrhythmia, cardiac shock, and even sudden death. Although the pathogenesis remains not fully clear, the metabolism of glucose and lipid metabolism, myocardial cells with abnormal energy metabolism, myocardial fibrosis, oxidative stress, and cell death are some possible pathogenic causes. This paper reviews the reported pathogenesis of DCM from cellular, tissue and molecular aspects to provide a basis for clinical prevention and treatment.diabetic cardiomyopathy; pathogenesis; metabolic disorders; myocardial fibrosis

参考文献/References

[1]Voulgari C,Papadoglannis D,Tentolouris N. Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes tocurrent diagnosis and management strategies[J].Vasc Health Risk Manag,2010,6:883-903.
[2]Mytas DZ,Stougiannos PN,Zairis MN,et al.Diabetic myocardialdisease:pathophysiology, early diagnosis and therapeutic options[J].J Diabetes Complications,2009,23(4):273-282.
[3]Tarquini R,Lazzeri C,Pala L,et al.The diabetic cardiomyopathy[J].Acta Diabetol,2011,48(3):173-181.
[4]Wenmeng W,Qizhu T.Early administration of trimetazidine mayprevent or ameliorate diabetic cardiomyopathy[J].Med Hypotheses,2011,76(2):181-183.
[5]FalcaoPires I,LeiteMoreira AF. Diabetic cardiomyopathy: understanding the molecular and cellular basis to progression diagnosis and treatment[J].Heart Fail Rev,2012,17(3):325-344.
[6]Flotats A,Carrio I.Is cardiac autonomic neuropathy the basis of nonischemic diabetic cardiomyopathy?[J].JACC Cardiovasc Imag,2010,3(12):1216-1217.
[7]Halliwell B.Biochemistry of oxidative stress[J].Biochem Soc Trans,2007,35(Pt 5):1147-1150.
[8]Camici GG,Schiavoni M,Francia P,et al.Genetic deletion of p66(Shc) adaptor pro tein prevents hyperglycemiainduced endothelial dysfunction and oxidative stress[J].Proc Natl Acad Sci U S A,2007,104(12):5217-5222.
[9]Aronson D. Hyperglycemia and the pathobiology of diabetic complications[J].Adv Cardiol,2008,45:1-16.
[10]Gherasim L,Tasca C,Havriliuc C,et al.A morphological quantitative study of small vessels in diabetic cardiomyopathy[J].Morphol Embryol(Bucur),1985,31(1):191-195.
[11]Fischer VW,Barner HB,Larose LS.Pathomorphologic aspects of muscular tissue in diabetes mellitus[J].Hum Pathol,1984,15(12):1127-1136.

备注/Memo

备注/Memo:
收稿日期：2013-03-20.基金项目：国家自然科学基金项目资助(30960138) 通讯作者：李建美，主任医师，主要从事冠心病研究 Email：ljm@sina.com 作者简介：罗南方，硕士生 Email：21500236@qq.com
更新日期/Last Update: 2013-09-30