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¡¶ÐÄÔàÔÓÖ¾¡·[ISSN:1009-7236/CN:61-1268/R]

ÆÚÊý:

2013ÄêµÚ6ÆÚ

Ò³Âë:

711-715

À¸Ä¿:

×ÛÊö

³ö°æÈÕÆÚ:

2013-11-25

ÎÄÕÂÐÅÏ¢/Info

Title:

Research progress of induced pluripotent stem cells in in vitro models of arrhythmogenic diseases

×÷Õß:

ÖÖ³¯Ñô; ê°Î°½ø; ÖÜ óÞ

£¨Î÷°²½»Í¨´óѧҽѧԺҩÀíѧϵ£¬ÉÂÎ÷ Î÷°² 710061£©

Author(s):

CHONG Zhao yang;  ZANG Wei jin;  ZHOU Jun

(Department of Pharmacology, College of Medicine, Xi¡¯an Jiaotong University, Xi¡¯an 710061, Shaanxi, China)

¹Ø¼ü´Ê:

ÐÄÂÉʧ³£; ÓÕµ¼ÐͶàÄܸÉϸ°û; ÌåÍâÄ£ÐÍ

Keywords:

arrhythmia;  induced pluripotent stem cells;  in vitro model

·ÖÀàºÅ:

R541.7

DOI:

-

ÎÄÏ×±êʶÂë:

A

ÕªÒª:

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Abstract:

Arrhythmogenic diseases can be life threatening. Many genetic arrhythmias are caused by gene mutations. As an in vitro model to study hereditary arrhythmogenic diseases, induced pluripotent stem cellª²derived cardiomyocytes (iPSC-CMs) are induced by somatic cells obtained from patients, offering new insight into the study of arrhythmia pathogenesis.This paper mainly reviews the generation process of the induced cardiomyocytes from iPSCs and the iPS models of arrhythmogenic diseases including long QT syndrome, catecholamineª²dependent ventricular tachycardia and arrhythmogenic right ventricular cardiomyopathy.

²Î¿¼ÎÄÏ×/References

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¸üÐÂÈÕÆÚ/Last Update: 2013-11-20