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|本期目录/Table of Contents|

成纤维细胞活化在低氧性肺血管重构中的作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第6期
页码:
716-718725
栏目:
综述
出版日期:
2013-11-25

文章信息/Info

Title:
Role of fibroblasts activation in hypoxic pulmonary vascular remodeling
作者:
殷 广1; 2; 罗 颖2
（第四军医大学：1.航空航天医学系，2.病理学与病理生理学教研室，陕西 西安 710032）
Author(s):
YIN Guang1; 2;  LUO Ying2
(1.School of Aerospace Medicine, 2.Department of Pathology and Pathophysiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
低氧; 外膜; 肺血管重构; 成纤维细胞; 肌纤维母细胞
Keywords:
hypoxia;  adventitia;  pulmonary vascular remodeling;  fibroblast;  myofibroblast
分类号:
R543.2
DOI:
-
文献标识码:
A
摘要:
以往在低氧性肺血管重构机制的研究中，外膜的作用往往被忽略。新近的研究表明，血管外膜特别是其中的成纤维细胞在调节血管功能中发挥着重要的作用。外膜中的成纤维细胞是低氧刺激的首要“损伤感受细胞”，低氧可以激活血管外膜成纤维细胞，活化的成纤维细胞既可以合成分泌细胞生长因子、炎症因子，进而促进中膜血管平滑肌细胞增殖，又可以转分化为平滑肌样细胞（肌纤维母细胞）、分泌胶原蛋白，导致血管重构。因此，低氧导致的成纤维细胞活化及表型转换在肺血管重构中起重要作用，贯穿着低氧性肺血管重构的整个病理过程。
Abstract:
Functions of the adventitia were often neglected in previous studies of hypoxic pulmonary vascular remodeling. Recent studies show that vascular adventitia, especially its fibroblasts, plays an important role in vascular function. Adventitia fibroblasts are the primary sensory cells under hypoxic condition and hypoxia can directly activate adventitia fibroblasts. Activated fibroblasts not only synthesize and secrete growth factors and cytokines to promote the proliferation of smooth muscle cells, but also transdifferentiate into smooth musclelike cells (myofibroblasts) and secrete collagen, resulting in vascular remodeling. Therefore, hypoxiainduced fibroblast activation plays a vital role in hypoxic pulmonary vascular remodeling and hypoxic pulmonary hypertension.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-03-05.基金项目：国家自然科学青年基金项目资助（81201516） 通讯作者：罗颖，讲师，主要从事低氧性肺动脉高压研究 Email:luoying@fmmu.edu.cn 作者简介：殷广，本科生 Email:410182709@163.com
更新日期/Last Update: 2013-11-20