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|本期目录/Table of Contents|

DNA甲基化修饰在心血管疾病中的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第6期
页码:
722-725
栏目:
综述
出版日期:
2013-11-25

文章信息/Info

Title:
DNA methylation and cardiovascular disease
作者:
惠 红; 陈文佳 综述; 尹新华 审校
(哈尔滨医科大学附属第一医院心内科，黑龙江 哈尔滨 150001)
Author(s):
HUI Hong;  CHEN Wen jia;  YIN Xin hua
(Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
DNA甲基化; 修饰; 心血管疾病
Keywords:
DNA methylation;  modification;  angiocardiopathy
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
DNA甲基化是广泛存在于真核生物中的基因修饰机制，对细胞分化过程和基因转录发挥着重要的调节功能。DNA甲基化能够遗传并且受到环境、饮食、衰老和疾病的影响。近年来很多研究发现，DNA甲基化在心血管疾病（如动脉粥样硬化、高血压和心力衰竭等）的发生发展中发挥重要作用。
Abstract:
DNA methylation is a pervasive feature of eukaryotic genomes, which is fundamental for cellular differentiation processes and control of transcriptional potentials. DNA methylation patterns can be inherited and influenced by the environment, diet and aging and can be disrupted in diseases. Recent evidence has suggested that DNA methylomes is important in the development of cardiovascular diseases including atherosclerosis, hypertension and heart failure.

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备注/Memo

备注/Memo:
收稿日期：2013-03-11.通讯作者：尹新华，教授，主要从事冠心病和心力衰竭研究 Email：xinhua_yin@163.com 作者简介：惠红，硕士生 Email：huihonghyd@163.com
更新日期/Last Update: 2013-11-20