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|本期目录/Table of Contents|

长链非编码RNAs与心脏发育及心血管系统相关疾病的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第1期
页码:
87-90
栏目:
综述
出版日期:
2013-12-02

文章信息/Info

Title:
Relationship between long noncoding RNAs and heart development as well as cardiovascular diseases
作者:
刘雪华; 余章斌
（南京医科大学附属南京妇幼保健院儿科，江苏 南京 210004）
Author(s):
LIU Xue-hua;  YU Zhang-bin
(Department of Pediatrics, Nanjing Maternal and Child Health Hospital, Nanjing Medical University, Nanjing, 210004, Jiangsu, China)
关键词:
长链非编码RNAs; 心脏发育; 心血管相关疾病
Keywords:
long noncoding RNAs;  heart development
分类号:
R331.31；R54
DOI:
-
文献标识码:
A
摘要:
长链非编码RNAs（lncRNAs）是生物体内转录本长度超过200 nt的RNA分子，它们并不编码蛋白，但参与了X染色体沉默，基因组印记以及染色质修饰，转录激活，转录干扰以及核内运输等多种重要的调控过程。近年研究表明，lncRNAs与心脏发育及心血管系统相关疾病密切相关，一些特异的lncRNAs有可能为心血管系统相关疾病的诊断和治疗提供新的靶点和研发新的药物。
Abstract:
Long noncoding RNAs (lncRNAs) are molecules often longer than 200 nt in length, which are non-protein coding genes. They play important roles in X chromosome inactivation, genomic imprinting, chromatin modification, transcriptional activation, transcription interference, and regulation of nuclear transport. Recent studies show that lncRNAs are closely related with heart development or cardiovascular diseases. Some specific lncRNAs are potential markers in the early diagnosis or treatment of cardiovascular diseases.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期: 2013-08-25.基金项目：国家自然科学基金项目资助（81070500），南京市医学科技发展基金项目资助（QRX11107） 通讯作者：余章斌，副主任医师，主要从事围产期心脏发育研究 Email:zhangbinyu@njmu.edu.cn 作者简介：刘雪华，硕士生 Email:snowsharif@163.com
更新日期/Last Update: 2014-01-20