血清同型半胱氨酸高水平的老年高血压病患者尿微量白蛋白的变化
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2014年第2期
- 页码:
- 152-153159
- 栏目:
- 临床研究
- 出版日期:
- 2014-01-20
文章信息/Info
- Title:
- Changes of urinary microalbumin levels in elderly patients with essential hypertension and high homocysteine levels
- Author(s):
- ZHOU Ying-zhi; MA Li-na; YANG Wei; QIAN Yu-ying; LI Yun; FENG Ming
- (Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China)
- Keywords:
- hypertension; essential; homocysteine; urinary microalbuminuria; elderly
- 分类号:
- R149.4；R544.1
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的:了解老年高血压病患者血清同型半胱氨酸（homocysteine,Hcy）高水平的老年高血压病患者尿微量白蛋白的变化。方法： 对120例老年高血压病患者进行血清Hcy的测定及动态血压的测定，高Hcy组59例，正常Hcy组61例，比较两组尿微量白蛋白的水平。结果： 高Hcy组患者尿微量白蛋白显著高于正常Hcy组［(22±4) μg/min vs.(15±4) μg/min，P<0.01］。结论： 高Hcy组高血压病患者尿微量白蛋白升高，Hcy加重高血压病患者的肾损害。
- Abstract:
- AIM:To explore the changes of urinary microalbumin levels in elderly patients with essential hypertension with high homocysteine levels. METHODS: Serum homocysteine and ambulatory blood pressure were measured in 120 elderly patients with hypertension. The patients were divided into two groups: high Hcy group (n=59) and control group (n=61), and urinary microalbumin was compared between groups. RESULTS: The urinary microalbumin in high Hcy group was higher than in control group ［(22±4) μg/min vs.(15±4) μg/min, P<0.01］. CONCLUSION: High urinary microalbumin in Hcy group suggests that Hcy increases renal damage in elderly patients with essential hypertension.
参考文献/References
[1]Lu X,Shi P,Luo CY,et al.Prevalence of hypertension in overweight and obese children from a large school-based population in Shanghai,China[J].BMC Public Health,2013,13:24.
[2]李建平,霍 勇,刘 平,等.马来酸依那普利叶酸片降压、降同型半胱氨酸的疗效和安全性[J].北京大学学报(医学版),2007,39(6):614-618.
[3]Blankestijn PJ,Joles JA.Hypertension:Renal denervation in chronic kidney disease[J].Nat Rev Nephrol,2012,8(8):439-440.
[4]Savard S,Lavoie P,Villeneuve C,et al.eNOS gene delivery prevents hypertension and reduces renal failure and injury in rats with reduced renal mass[J].Nephrol Dial Transplant,2012,27(6):2182-2190.
[5]Grassi G,Bertoli S,Seravalle G.Sympathetic nervous system:role in hypertension and in chronic kidney disease[J].Curr Opin Nephrol Hypertens,2012,21(1):46-51.
[6]Salvetti M,Muiesan ML,Paini A,et al.Left ventricular hypertrophy and renal dysfunction during antihypertensive treatment adversely affect cardiovascular prognosis in hypertensive patients[J].J Hypertens,2012,30(2):411-420.
[7]Cerasola G,Cottone S,Dlgnoto G,et al.Microalbuminuria, renal dysfunction and cardiovascular complication in essential hypertension[J].J Hypertens,1996,14(7):915-920.
[8]Abcabo G,Fava C,Dagradi R,et al.Acute hyperhomocysteinemia induces a reduction in arterial distensibility and compliance[J].J Hypertens,2009,22(4):775-781.
[9]Faraci FM,Lentz SR.Hyperhomocysteinemia,oxidative stress and cerebral vascular dysfunction[J].Stroke,2004,35(2):345-347.
[10]Towfighi A,Markovic D,Ovbiagele B. Pronounced association of elevated serum homocysteine with stroke in subgroups of individuals: a nationwide study[J].J Neurol Sci,2010,298(1-2):153-157.
[11]Qin X,Li J,Cui Y,et al.Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults:do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses?[J].Pharmacogenet Genomics,2012,22(6):421-428.
备注/Memo
- 备注/Memo:
- 收稿日期：2013-08-25
基金项目：教育部人文社会科学研究基金项目资助（12YJCZH146）
通讯作者：马丽娜，主治医师，主要从事老年医学临床研究Email：malina0883@aliyun.com
作者简介：周英智，副主任医师Email：malina0883@126.com
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