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|本期目录/Table of Contents|

冠心病与睡眠呼吸暂停综合征关系的Meta分析

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第2期
页码:
179-183
栏目:
临床研究
出版日期:
2014-01-20

文章信息/Info

Title:
A meta-analysis on the relationship between sleep apnea syndrome and coronary artery disease
作者:
侯 扬1; 2;  孙晓斐2
(1.济南大学、山东省医学科学院医学与生命科学学院，山东 济南 250062；2.山东省医学科学院附属济宁市第一人民医院心内科，山东 济宁 272011)
Author(s):
HOU Yang1; 2;  SUN Xiao-fei2
(1.School of Medicine and Life Sciences, University of Jinan & Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China; 2.Department of Cardiology, Jining First People’s Hospital, Academy of Medical Science of Shandong Province, Jining 272100, Shandong, China)
关键词:
冠状动脉疾病; 睡眠呼吸暂停综合征; 危险因素; Meta分析
Keywords:
coronary diseases;  sleep apnea syndrome;  risk factors;  meta-analysis
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:通过Meta分析有关冠心病与睡眠呼吸暂停综合征（sleep apnea syndrome,SAS）关系的病例对照研究的文献，为冠心病与SAS相互关系的研究提供循证医学的证据。方法： 收集和整理有关冠心病与SAS关系的病例对照研究的文献，观察对比冠心病和非冠心病患者群中SAS的发生率，用RevMan 5.2分析软件、Stata12SE分析软件对纳入的研究进行异质性检验和合并分析，结果以比数比（odds ratio，OR）表示，计算95%可信区间（95%CI），评估发表性偏倚和敏感性检验。结果： 纳入的14组研究根据SAS定义不同分为两组分析，分析前9项研究显示OR=2.95,95%CI(2.25-3.87)，P<0.05，差异有统计学意义；后5项研究R=3.42, 95%CI(1.74-6.71)，P<0.05，差异有统计学意义，表示SAS发生率与冠心病具有正的关联性，经检验不存在发表偏倚且敏感度分析示稳定度较高。结论： 冠心病患者群中SAS的发生率高于非冠心病患者，SAS是冠心病的危险因素。
Abstract:
AIM:To analyze case-control studies on the relationship between coronary artery diseases (CAD) and sleep apnea syndrome (SAS) and to provide support of evidence-based medicine for studies regarding SAS and CAD. METHODS: Literature reports of case-control studies on the relationship between CAD and SAS were collected and the morbidity of SAS in CAD group and non-CAD group was compared. Heterogeneity and original data were analyzed by Stata12 and RevMan5.2 and the outcomes were indicated by OR and 95% CI. Publication bias and sensitivity were also tested. RESULTS: Selected studies were categorized into two groups according to different definitions of SAS. The outcomes of the first group with nine studies were statistically significant (OR=2.95, 95% CI 2.25-3.87, P<0.05) and the outcomes of the second group with five studies were also statistically significant (OR=3.42, 95% CI 1.74-6.71, P<0.05). Bias test showed no publication bias and sensitivity analysis showed that the results were stable. The morbidity of SAS showed a positive correlation with CAD. CONCLUSION: The morbidity of SAS in CAD patients is higher than in patients without CAD. SAS is a risk factor for CAD.

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备注/Memo

备注/Memo:
收稿日期：2013-08-28.
通讯作者：孙晓斐，主任医师，主要从事介入心脏病学研究Email：houyang711@qq.com
作者简介：侯扬，硕士生Email： 632844939@qq.com
更新日期/Last Update: 2014-01-16