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大剂量氯吡格雷联合阿司匹林、尿激酶溶栓治疗急性ST段抬高型心肌梗死的疗效观察

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第2期
页码:
184-186
栏目:
临床研究
出版日期:
2014-01-20

文章信息/Info

Title:
Clinical study of aspirin and urokinase plus high-dose clopidogrel in patients with acute ST-segment elevation myocardial infarction
作者:
陈淑敏1; 2; 侯贺功1
(1.巨野县人民医院心内二科，山东 巨野 274900；2.青岛大学研究生院，山东 青岛 266071)
Author(s):
CHEN Shu-min1; 2;  HOU He-gong1
(1.Second Department of Cardiology, Juye People’s Hospital, Juye 274900, Shandong, China; 2.Graduate School of Qingdao University, Qingdao 266071, Shandong, China)
关键词:
心肌梗死; 急性; ST段抬高型; 氯吡格雷; 阿司匹林; 尿激酶
Keywords:
clopidogrel;  aspirin;  urokinase;  acute ST-segment elevation myocardial infarction
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的:探讨大剂量氯吡格雷联合阿司匹林、尿激酶溶栓治疗急性ST段抬高型心肌梗死（STEMI）的临床疗效。方法： 将70 例STEMI患者随机等量分为两组, 在尿激酶溶栓的基础上，试药组进行大剂量氯吡格雷联合阿司匹林治疗, 对照组只进行常规阿司匹林治疗, 治疗1周后观察比较两组的疗效和安全性。结果： 两组复合终点事件的差异显著, 试药组的近期疗效显著优于对照组(P<0.05)，两组的出血发生率无显著差异。结论： STEMI患者在应用阿司匹林，尿激酶治疗基础上加用大剂量氯吡格雷，可显著降低住院期间的病死率和心血管事件的发生。
Abstract:
AIM:To investigate the therapeutic effect of aspirin and urokinase plus high-dose clopidogrel in treating patients with acute ST-elevation myocardial infarction. METHODS: A total of 70 inpatients were randomized into two groups: treatment group and control group. Patients in control group received routine treatment of aspirin and urokinase and patients in treatment group were given conventional treatment plus high-dose clopidogrel. The patients in both groups were treated for 1 week and the efficacy and safety were compared. RESULTS: Significant differences were found in the two groups. Short-term efficacy in the treatment group was higher than in the control group (P<0.05). No significant difference in the rate of hemorrhage was observed between groups. CONCLUSION: Administration of aspirin and urokinase plus high-dose clopidogrel can significantly reduce the mortality rate and major cardiovascular events in patients with acute myocardial infarction with ST-elevation.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-07-23.
作者简介：陈淑敏，主治医师，硕士生Email：jyxyycsm@126.com
更新日期/Last Update: 2014-01-16