钙摄入与心血管疾病风险的研究进展
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2014年第2期
- 页码:
- 218-221
- 栏目:
- 综述
- 出版日期:
- 2014-01-20
文章信息/Info
- Title:
- Advances in research of calcium intake and cardiovascular diseases
- Author(s):
- WANG Jin-xi; LI Hong-wei
- (Cardiovascular Center of Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China)
- Keywords:
- dietary calcium; calcium supplements; cardiovascular disease
- 分类号:
- Q582；R714.252
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 钙摄入对于心血管系统的健康效应正日益受到争议。尽管早期研究提示钙质可能具有心血管系统保护作用，日益增多的证据支持过量摄入膳食钙及补充钙剂可能对心血管系统产生不利影响。钙可通过上调肾素-血管紧张素-醛固酮系统、促进血管钙化、导致短期内血钙波动、引发高凝状态等多种机制影响心血管系统。钙对于心血管系统的潜在获益与风险亟需大规模试验进一步深入评估。
- Abstract:
- The health effects of calcium intake on the cardiovascular system have become increasingly contentious. Despite some earlier studies suggesting a protective role of calcium against cardiovascular diseases, there is increasing evidence supporting the notion that excess dietary calcium and calcium supplements may have adverse effects on the cardiovascular system with the underlying mechanisms of upregulation of the renin-angiotensin-aldosterone system, vascular calcification, rise of serum calcium and hypercoagulability. The benefits and risks of calcium intake on the cardiovascular system remain to be further investigated.
参考文献/References
[1]Bailey RL,Dodd KW,Goldman JA,et al.Estimation of total usual calcium and vitamin D intakes in the United States[J].J Nutr,2010,140(4):817-822.
[2]Larsson SC.Are calcium supplements harmful to cardiovascular disease?[J].JAMA Intern Med,2013,173(8):647-648.
[3]Bolland MJ,Avenell A,Baron JA,et al.Effect of calcium supplements on risk of myocardial infarction and cardiovascular events:meta-analysis[J].BMJ,2010,341:c3691.
[4]Bolland MJ,Grey A,Gamble GD,et al.Calcium and vitamin D supplements and health outcomes:a reanalysis of the Women’s Health Initiative (WHI) limited-access data set[J].Am J Clin Nutr,2011,94(4):1144-1149.
[5]Villegas R,Gao YT,Dai Q,et al.Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women’s Health Study[J].Am J Clin Nutr,2009,89(4):1059-1067.
[6]Umesawa M,Iso H,Ishihara J,et al.Dietary Calcium Intake and Risks of Stroke,Its Subtypes,and Coronary Heart Disease in Japanese The JPHC Study Cohort I[J].Stroke,2008,39(9):2449-2456.
[7]Kaluza J,Orsini N,Levitan EB,et al. Dietary calcium and magnesium intake and mortality:a prospective study of men[J].Am J Epidemiol,2010,171(7):801-807.
[8]Larsson SC,Virtamo J,Wolk A.Potassium,calcium, and magnesium intakes and risk of stroke in women[J].Am J Epidemiol,2011,174(1):35-43.
[9]Wang L,Manson JE,Sesso HD.Calcium intake and risk of cardiovascular disease[J].Am J Cardiovasc Drugs,2012,12(2):105-116.
[10]Li K,Kaaks R,Linseisen J,et al.Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg)[J].Heart,2012,98(12):920-925.
[11]Xiao Q,Murphy RA, Houston DK,et al.Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health-AARP diet and health study[J].JAMA Intern Med, 2013, 173(8):639-646.
[12]Micha lsson K,Melhus H,Warensj Lemming E,et al.Long term calcium intake and rates of all cause and cardiovascular mortality:community based prospective longitudinal cohort study[J].BMJ,2013,346:f228.
[13]Bolland MJ,Grey A,Avenell A,et al.Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis[J].BMJ,2011,342:d2040.
[14]Bolland MJ,Barber PA, Doughty RN,et al.Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial[J].BMJ,2008,336(7638):262-266.
[15]Pentti K,Tuppurainen MT,Honkanen R,et al.Use of calcium supplements and the risk of coronary heart disease in 52-62-year-old women:The Kuopio Osteoporosis Risk Factor and Prevention Study[J].Maturitas,2009,63(1):73-78.
[16]Samelson EJ,Booth SL,Fox CS,et al.Calcium intake is not associated with increased coronary artery calcification: the Framingham Study[J].Am J Clin Nutr,2012,96(6):1274-1280.
[17]Vervloet MG,van Ittersum FJ,Büttler RM,et al.Effects of dietary phosphate and calcium intake on fibroblast growth factor-23[J].Clin J Am Nephrol,2011,6(2):383-389.
[18]Reid IR, Bolland MJ, Avenell A, et al. Cardiovascular effects of calcium supplementation[J].Osteoporos Int,2011,22(6):1649-1658.
[19]Lee JH, O'Keefe JH,Bell D,et al.Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?[J].J Am Coll Cardiol,2008,52(24):1949-1956.
[20]Wang TK,Bolland MJ,Pelt NC,et al.Relationships between vascular calcification, calcium metabolism, bone density, and fractures[J].J Bone Miner Res,2010,25(12):2777-2785.
[21]Williams DM,Fraser A.Lawlor DA.Associations of vitamin D, parathyroid hormone and calcium with cardiovascular risk factors in US adolescents[J].Heart,2011,97(4):315-320.
[22]Hagstr?m E,Hellman P,Larsson TE,et al.Plasma parathyroid hormone and the risk of cardiovascular mortality in the community[J].Circulation,2009,119(21):2765-2771.
备注/Memo
- 备注/Memo:
- 收稿日期：2013-06-28.
通讯作者：李虹伟，主任医师，主要从事糖代谢与心血管疾病关系研究 Email：mcw19656@gmail.com
作者简介：王锦溪，硕士生Email：wxslbz@163.com
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