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|本期目录/Table of Contents|

生长分化因子15在心血管疾病中的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第3期
页码:
361-365
栏目:
综述
出版日期:
2014-03-20

文章信息/Info

Title:
Research progress in growth differentiation factor 15 and cardiovascular diseases
作者:
刘海涛1; 张海锋2; 尹 涛1;  李 飞1; 李伟杰1; 王海昌1
(第四军医大学:1.西京医院心血管内科，
2.基础医学教学实验中心，陕西 西安 710032)
Author(s):
LIU Hai tao1;  ZHANG Hai feng2;  YIN Tao1;  LI Fei1;  LI Wei jie1;  WANG Hai chang1
(1.Department of Cardiology, Xijing Hospital,
2.Department of Preclinical Medical Teaching Experiment Center, Fourth Military University, Xi’an 710032, Shaanxi, China)
关键词:
生长分化因子15; 心血管疾病; 标志物
Keywords:
growth-differentiation factor 15;  biomarker;  cardiovascular disease;  protection
分类号:
R543
DOI:
-
文献标识码:
A
摘要:
生长分化因子15（GDF-15）是细胞因子超家族转化生长因子β中的成员。在生理条件下GDF-15在心肌中呈弱表达，而在诸多病理条件下其表达水平增加。越来越多的证据表明，GDF-15水平升高是心血管疾病的一种很有价值的预后标志物。此外，GDF-15对心肌细胞具有内源性抗肥厚和拮抗心脏缺血/再灌注损伤的性质。GDF-15正在成为评估和管理心脏病患者的一种很有前途的生物学标志物，并对心肌细胞具有潜在的保护作用。
Abstract:
Growth-differentiation factor 15 (GDF-15) is a distant member of the transforming growth factor-β cytokine superfamily. In myocardium, GDF-15 is weakly expressed under physiological conditions. However, its expression level is increased in response to pathological stress. Growing evidence indicates that the elevated level of GDF-15 is a promising prognostic biomarker in cardiovascular diseases. Moreover, GDF-15 exhibits the properties of endogenous anti-hypertrophy of cardiomyocytes and protecting the heart from ischemia and reperfusion insult.

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备注/Memo

备注/Memo:
收稿日期：2013-08-10.
通讯作者：王海昌，主任医师，主要从事冠心病与心律失常诊断与治疗 Email：wanghc@fmmu.edu.cn
作者简介：刘海涛，主治医师，博士 Email：xjcardio@hotmail.com
更新日期/Last Update: 2014-03-21