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|本期目录/Table of Contents|

冠心病患者抗心磷脂抗体与PON、ox-LDL、MDA和SOD的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第4期
页码:
453-455
栏目:
临床研究
出版日期:
2014-04-25

文章信息/Info

Title:
Relationship between anticardiolipin antibody and paraoxonase, ox-LDL, MDA and SOD in patients with coronary heart disease
作者:
白 玲1; 谭雪峰2; 刘 平1
(1.西安交通大学医学部第一临床医学院心血管内科，环境与疾病相关基因教育部重点实验室，陕西 西安 710061；
2.泾阳县医院心内科，陕西 咸阳713700)
Author(s):
BAI Ling1;  TAN Xue-feng2;  LIU Ping1
(1.Department of Cardiovascology, First Affiliated Hospital, Medical School, Xi’an Jiaotong University & Key Laboratory of Environment and Genes Related to Disease, Ministry of Education, Xi’an 710061, Shaanxi, China;
2.Department of Cardiology, Jingyang Hospital, Xianyang 713700, Shaanxi, China)
关键词:
冠状动脉疾病; 抗心磷脂抗体; 对氧磷酶
Keywords:
coronary disease;  anticardiolipin antibody;  paraoxonase
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:观察和分析冠心病患者抗心磷脂抗体（ACA）与血清对氧磷酶（PON）活性、氧化低密度脂蛋白（ox-LDL)、丙二醛（MDA）和超氧化物歧化酶（SOD)的相关性。方法： 酶联免疫法检测118例冠心病患者、68例正常对照者血清ACA、ox-LDL、硫代巴比妥酸法测定MDA、黄嘌呤氧化酶法测定SOD、乙酸苯酯法测定PON。结果： 冠心病患者ACA阳性率为24%，显著高于对照组（阳性率为9%，P<0.05）。ACA阳性冠心病患者PON活性为(122±40) kU/L、ox-LDL为(0.81±0.26) mg/L、MDA为(7.6±1.1) μmol/L、SOD为(72±20) μU/L，与ACA阴性冠心病相比PON活性降低，ox-LDL、MDA升高，SOD无明显变化。相关分析显示PON活性与ox-LDL、MDA呈负相关（分别r=-0.825,P<0.01；r=-0.735，P<0.01），与SOD无相关性。结论： ACA阳性冠心病患者反映脂质过氧化程度的ox-LDL、MDA增高，而PON活性降低。
Abstract:
AIM: To observe and analyze the relationship between anticardiolipin antibody (ACA) and paraoxonase (PON), oxidized low-density lipoprotein (ox-LDL), malondialdehycle (MDA), superoxide dismutase (SOD) in patients with coronary heart disease (CHD). METHODS: ACA and ox-LDL were measured by enzyme-linked immunosorbent assay, MDA by thiobarbiuric acid, SOD by xanthine superoxidase, PON by the method of phenyl acetate in 118 patients with CHD and 68 healthy persons. RESULT: The ACA positive rate of CHD was 24%, which was significantly higher than that of healthy persons (the ACA positive rate was 9%, P<0.05) PON, ox-LDL, MDA, SOD levels were (122±40) kU/L, (0.81±0.26) mg/L, (7.6±1.1) μmol/L and (72±20) μU/ml, respectively, in ACA positive CHD. PON was significantly decreased (P<0.05), ox-LDL and MDA levels were significantly increased (P<0.05), but SOD was not different compared with ACA negative CHD. There was a negative correlation between PON and ox-LDL, MDA by correlation analysis, respectively (r=-0.825, P<0.01; r=-0.735, P<0.01). CONCLUSION: Lipid peroxidation levels (ox-LDL, MDA) were increased and the levels of PON were decreased in ACA-positive CHD.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2014-01-08.作者简介：白玲，副主任医师，主要从事冠心病、心力衰竭研究 Email: bailingb21@sina.com 共同第一作者：谭雪峰，主治医师 Email:747750715@qq.com
更新日期/Last Update: 2014-05-06