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|本期目录/Table of Contents|

调节性T细胞—动脉粥样硬化治疗的新靶点

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第4期
页码:
487-490
栏目:
综述
出版日期:
2014-04-25

文章信息/Info

Title:
Regulatory T cells: New therapeutic targets of atherosclerosis
作者:
凌秋洋1; 2; 宗刚军2
(1.安徽医科大学无锡临床学院，江苏 无锡 214044；
2.中国人民解放军第101医院心血管内科，江苏 无锡 214044）
Author(s):
LING Qiu-yang1; 2;  ZONG Gang-jun2
(1.Wuxi Clinical Hospital, Anhui medical Umuersity, Wuxi 214044, Jiangsu, China;
2.Department of Cardiology, PLA 101 Hospital, Wuxi 214044, Jiangsu, China)
关键词:
调节性T细胞; 动脉粥样硬化; 治疗靶点
Keywords:
regulatory T cell;  atherosclerosis;  therapentic target
分类号:
R543.5
DOI:
-
文献标识码:
A
摘要:
动脉粥样硬化（atherosclerosis，AS）是血管壁的一种慢性炎症疾病，免疫系统在其发生发展中起着重要的作用。有研究表明，调节性T（regulatory T，Treg）细胞参与了AS的炎症反应，通过下调其反应可延缓疾病的进程。本文综述了近年有关Treg细胞与AS关系的文献，探讨了Treg细胞在AS发生发展中的重要作用，说明了CD3对Treg细胞增殖的影响及与AS的关系，提出了AS治疗的免疫学新靶点。
Abstract:
The concept that atherosclerosis (AS) is a chronic inflammatory disease of the arterial wall has been widely accepted and the immune system has been reported to play an important role in AS occurrence and progression. New research shows that Treg cells can inhibit inflammation in AS, downregulate the inflammation responses and slow the progression of AS. This paper reviews the recent literatures on the relationship between AS and Treg cells, explores the important role of Treg cells in AS occurrence and progression, illustrates the effect of CD3 on the proliferation of Treg cells and its relationship with AS and recommends the new target in the treatment of AS immunology.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-11-12.通讯作者：宗刚军，副主任医师，主要从事高血压病基础与临床研究 Email：zonggj@163.com 作者简介：凌秋洋，硕士生 Email：lqy8586@163.com
更新日期/Last Update: 2014-05-06