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Title:: Relationship of plasma hyperhomocysteinemia and total ischia burden in angina pectoris

作者:: 叶辉¹; 叶千琨²; 张云芳¹; 李瑛¹; 黄耀辉¹; (1.深圳市第二人民医院心内特诊科，广东深圳 518035；
2.香港浸会大学环境与公共卫生管理学院，香港)

Author(s):: YE Hui¹; YE Qian-kun²; ZHANG Yun-fang¹; LI Ying¹; HUANG Yao-hui¹; (1.Department of Specific Diagnosis, Second Hospital, Shenzhen 518035, Guangdong, China;
2.College of Science in Environmental and Public Health Management, Hong Kong Baptist University, Hong Kong, China)

关键词:: 冠状动脉疾病; 同型半胱氨酸; 心肌缺血总负荷

Keywords:: coronary disease; hyperhomocysteinemia; total ischia burden

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的:研究高同型半胱氨酸水平与心绞痛心肌缺血总负荷的关系。方法：随机收集90例不稳定型心绞痛患者及90例稳定型心绞痛患者，观察高同型半胱氨酸血症与心肌缺血总负荷的关系。结果：不稳定型心绞痛组血同型半胱氨酸水平和心肌缺血总负荷显著高于稳定型心绞痛组（P<0.05)。稳定型心绞痛患者高同型半胱氨酸血症者，其心肌缺血总负荷高于同型半胱氨酸正常组（P<0.05)。不稳定型心绞痛组高同型半胱氨酸血症患者，其心肌缺血总负荷也明显高于血同型半胱氨酸正常者(P<0.01)。结论：高同型半胱氨酸血症与心绞痛患者心肌缺血总负荷增加有关联。

Abstract:: AIM:To examine whether elevated plasma total homocysteine (Hcy) is a risk factor for total ischia burden in angina pectoris. METHODS: The study consisted of 90 cases of stable angina pectoris (SAP) and 90 cases of unstable angina pectoris (UAP) and the difference in total ischia burden was observed between hyperhomocysteinemia (Hhcy) and non-Hhcy in angina pectoris patients. RESULTS: The levels of plasma total Hcy and total ischia burden in UAP were significantly higher than those in SAP (P<0.05). The total ischia burden of SAP and UAP patients in Hhcy was significantly higher than that in normal plasma Hcy (P<0.01). CONCLUSION: Hhcy is a risk factor for total ischia burden in patients with angina pectoris.

参考文献/References

[1]Naghshtabrizi B,Shakerian F,Hajilooi M,et al.Plasma homocysteine level and its genotypes as a risk factor for coronary artery disease in patients undergoing coronary angiography[J].J Cardiovasc Dis Res,2012,3(4):276-279.
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[4]叶辉，严江涛，邵娇梅，等.血浆同型半胱氨酸水平及亚甲基四氢叶酸还原酶基因突变与脑卒中关系的病例对照研究[J].中华流行病学杂志,2004,25(11):958-961.
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高同型半胱氨酸血症与心绞痛心肌缺血总负荷的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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