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|本期目录/Table of Contents|

房颤血清生物标记物的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第5期
页码:
607-610
栏目:
综述
出版日期:
2014-05-25

文章信息/Info

Title:
Advances in serum biomarkers of atrial fibrillation
作者:
马 金; 丁春华
(广东省中医院心脏电生理研究室、心律失常诊疗中心，广东 广州 510006)
Author(s):
MA Jin;  DING Chun-hua
(Cardiac Electrophysiology Lab, Arrhythmia Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, China)
关键词:
心房颤动; 生物标记物; 纤维化; 炎症; 氧化应激
Keywords:
atrial fibrillation;  biomarker;  fibrosis;  inflammation;  oxidative stress
分类号:
R541.75
DOI:
-
文献标识码:
A
摘要:
心房颤动（AF）是目前临床上最常见的心律失常之一。绝大多数患者是在AF晚期已经出现无规则的心脏节律后被发现，治疗效果欠佳。近年，研究者开始关注AF早期无症状阶段的病理生理改变，发现纤维化、炎症和氧化应激等与AF密切相关，相应的生物标记物也被证明可以预示AF的发生和预后。血清生物标志物的变化是AF发生和预后的强预测因子。生物标记物作为一种廉价、安全的检测指标可以帮助临床医生对高危人群进行早期诊断、指导治疗、判断疗效和评估预后，具有较好的临床应用前景。
Abstract:
Atrial fibrillation (AF) is the most common cardiac arrhythmia. The majority of patients with irregular heartbeat or abnormal heart rhythm can be diagnosed as having AF. Recent research has begun to focus on the pathophysiology of AF in asymptomatic early stages. It has been found that fibrosis, inflammation and oxidative stress are closely related to AF. The related biomarkers have been shown valuable in predicting the occurrence and prognosis of AF. Changes in serum biomarkers are strong predictors of the occurrence and prognosis of AF. Biomarkers as an economical, non-invasive, and safe test can help clinicians identify at-risk populations. Biomarkers help in early diagnosis, disease prevention, drug target identification, and drug response.

参考文献/References

[1]Aldhoon B,Melenovsk? V,Peichl P,et al.New insights into mechanisms of atrial fibrillation[J].Physiol Res,2010,59(1):1-12.
[2]Santiago JJ,Dangerfield AL,Rattan SG,et al.Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro:expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts[J].Dev Dyn,2010,239(6):1573-1584.
[3]Kawamura M,Munetsugu Y,Kawasaki S,et al.Type III procollagen-N-peptide as a predictor of persistent atrial fibrillation recurrence after cardioversion[J].Europace, 2012,14(12):1719-1725.
[4]Okumura Y,Watanabe I,Nakai T,et al.Impact of biomarkers of inflammation and extracellular matrix turnover on the outcome of atrial fibrillation ablation: importance of matrix metalloproteinase-2 as a predictor of atrial fibrillation recurrence[J].J Cardiovasc Electrophysiol,2011,22(9):987-993.
[5]Swartz MF,Fink GW,Sarwar MF,et al.Elevated pre-operative serum peptides for collagen I and III synthesis result in post-surgical atrial fibrillation[J].J Am Coll Cardiol,2012,60(18):1799-1806.
[6]Moore L,Fan D,Basu R,et al.Tissue inhibitor of metalloproteinases(TIMPs)in heart failure[J].Heart Fail Rev,2012,17(4/5):693-706.
[7]Kalogeropoulos AS,Tsiodras S,Rigopoulos AG,et al.Novel association patterns of cardiac remodeling markers in patients with essential hypertension and atrial fibrillation[J].BMC Cardiovasc Disord,2011,11:77.
[8]Friedrichs K,Klinke A,Baldus S.Inflammatory pathways underlying atrial fibrillation[J].Trends Mol Med,2011,17(10):556-563.
[9]Patel P,Dokainish H,Tsai P,et al.Update on the association of inflammation and atrial fibrillation[J].J Cardiovasc Electrophysiol,2010,21(9):1064-1070.
[10]Marott SC,Nordestgaard BG,Zacho J,et al.Does elevated C-reactive protein increase atrial fibrillation risk? A Mendelian randomization of 47,000 individuals from the general population[J].J Am Coll Cardiol,2010,56(10):789-795.
[11]Kornej J,Reinhardt C,Kosiuk J,et al.Response of high-sensitive C-reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome[J].PLoS One,2012,7(8):e44165.
[12]Marcus GM,Whooley MA,Glidden DV,et al.Interleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul Study[J].Am Heart J,2008,155(2):303-309.
[13]Kaireviciute D,Blann AD,Balakrishnan B,et al.Characterisation and validity of inflammatory biomarkers in the prediction of post-operative atrial fibrillation in coronary artery disease patients[J].Thromb Haemost,2010,104(1):122-127.
[14]Sovari AA,Dudley SC Jr.Reactive Oxygen species-targeted therapeutic interventions for atrial fibrillation[J].Front Physiol,2012,3:311.
[15]Kim YM,Kattach H,Ratnatunga C,et al.Association of atrial nicotinamide adenine dinucleotide phosphate oxidase activity with the development of atrial fibrillation after cardiac surgery[J].J Am Coll Cardiol,2008,51(1):68-74.
[16]Neuman RB,Bloom HL,Shukrullah I,et al.Oxidative stress markers are associated with persistent atrial fibrillation[J].Clin Chem,2007,53(9):1652-1657.
[17]Shimano M,Shibata R,Inden Y,et al.Reactive oxidative metabolites are associated with atrial conduction disturbance in patients with atrial fibrillation[J].Heart Rhythm,2009,6(7):935-940.
[18]Beck-da-Silva L,de Bold A,Fraser M,et al.Brain natriuretic peptide predicts successful cardioversion in patients with atrial fibrillation and maintenance of sinus rhythm[J].Can J Cardiol,2004,20(12):1245-1248.
[19]Hussein AA,Saliba WI,Martin DO,et al.Plasma B-type natriuretic peptide levels and recurrent arrhythmia after successful ablation of lone atrial fibrillation[J].Circulation,2011,123(19):2077-2082.
[20]Dawson K,Wakili R,Ord?g B,et al.MicroRNA29:a mechanistic contributor and potential biomarker in atrial fibrillation[J].Circulation,2013,127(14):1466-1475,1475e1-28.

备注/Memo

备注/Memo:
收稿日期：2013-12-09.
作者简介：马金，实习研究员，博士 Email：majin556@126.com
更新日期/Last Update: 2014-06-05