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Title:: Research on prevention and treatment of calcific aortic valve stenosis in an aged population should be highlighted

作者:: 沈文锦; (解放军第三○九医院心内科，北京 100091)

Author(s):: SHEN Wen-jin; (Department of Cardiology, PLA 309 Hospital, Beijing 100091, China)

关键词:: 钙化性主动脉瓣狭窄; 老年人; 防止方法

Keywords:: calcific aortic valve stenosis; aged population; prophylactic-therapeutic measure

分类号:: R542.5

DOI:: -

文献标识码:: A

摘要:: 钙化性主动脉瓣狭窄（CAVS）是老年人的多发病，由于其无症状期漫长，先前一直被认为是“良性的”被动性老年退变现象。新近研究发现，CAVS的病变实际上是主动的发展过程，最终并可导致严重后果。到后期，一旦出现症状，病情很快恶化，致死率很高，此时只能进行外科换瓣手术解除狭窄，抢救和延长生命。目前尚无其他有效办法防止 CAVS的发生、发展，亟待深入研究。

Abstract:: Calcific aortic valve stenosis is widely prevalent in an aged population. In the past, calcific aortic valve stenosis was considered as a “benign” and passive process with aging due to its long asymptomatic period. Recently, calcific aortic valve stenosis is recognized as an active process and its development will ultimately lead to severe consequences. Once symptoms are developed in the late stage, the patient’s conditions can deteriorate quickly, leading to a poor prognosis with a high mortality. The standard therapy for severe calcific aortic valve is surgical aortic valve replacement; however, this procedure has its related surgical risks. There is no established way to retard disease progression and the most urgent research should be on its prevention and treatment.

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