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Title:: Influences of enhanced external counterpulsation on pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance

作者:: 王秋艳¹; 黄金林²; 侯海生³; 陈少川⁴; (秦皇岛军工医院：1.心内科，3.普外科，4.重症医学科，河北秦皇岛 066000；
2.北京军区北戴河疗养院，河北秦皇岛 066001)

Author(s):: WANG Qiu-yan¹; HUANG Jin-lin²; HOU Hai-sheng³; CHEN Shao-chuan⁴; (1.Department of Cardiology, 3.General Surgery, 4.Intensive Care Unit, Qinhuangdao Hospital of Military Industry, Qinhuangdao 066000, Hebei, China;
2.Beidaihe Sanatorium, Beijing Military Area Command, Qinhuangdao 066001, Hebei, China)

关键词:: 增强型体外反搏; 高血压; 原发性; 糖耐量减低; 内皮素; 脉搏波传导速度

Keywords:: enhanced external counterpulsation; hypertension; impaired glucose tolerance; endothelin; pulse wave velocity

分类号:: R541.3

DOI:: -

文献标识码:: A

摘要:: 目的:观察增强型体外反搏（EECP）对于改善高血压病并发糖耐量减低(IGT)患者血管内皮功能以及脉搏波传导速度（PWV)的影响。方法：将80例高血压病伴IGT患者分为EECP组（44例）和对照组（36例）。两组患者均进行常规降血压治疗，EECP组在常规治疗基础上进行EECP治疗。测定两组患者治疗前后血压、肱踝脉搏波传导速度（baPWV）以及血浆中内皮素（ET)和一氧化氮(NO)的含量，并进行对比分析。结果：两组患者治疗后收缩压和舒张压比治疗前均有显著下降（均P<0.01），但是两组间血压下降幅度并无明显差异。EECP组和对照组患者治疗后baPWV均有显著下降，ET也有显著下降，NO则有显著上升。但是EECP组baPWV、ET和NO较对照组改善的更为显著（均P<0.05）。结论： EECP能有效改善高血压病伴IGT患者血管内皮功能以及PWV。

Abstract:: AIM:To explore the effect of enhanced external counterpulsation (EECP) on the pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance (IGT). METHODS: Eighty hypertensive patients complicated by IGT were divided into treatment group (n=44, conventional treatment+EECP) and control group (n=36, conventional treatment). Both groups received conventional antihypertensive treatment, but EECP was added in the treatment group based on the conventional treatment. Blood pressure, pulse wave velocity, endothelin (ET) and nitric oxide (NO) were measured and compared between groups. RESULTS: Blood pressure in the two groups after treatment was dramatically reduced (P<0.01), but there was no significant difference between groups. The baPWV of patients in treatment group ［(1602±214) vs.(1890±251) cm/s, P<0.01］ and control group ［(1704±221) vs.(1893±243) cm/s, P<0.05］ after treatment decreased significantly. The ET level of patients in the treatment group ［(63±21) vs.(90±24) ng/L, P<0.01］ and control group ［(75±20) vs.(90±24) ng/L, P<0.05］ also decreased significantly after treatment. However, NO level of patients in treatment group ［(79±17) vs.(51±19) mmol/L, P<0.01］ and control group ［(68±17) vs.(51±18) μmol/L, P<0.05］ increased significantly after treatment. However, the baPWV, ET and NO of patients in treatment group improved more significantly compared with those in the control group (P<0.05). CONCLUSION: Enhanced external counterpulsation can improve the pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance.

参考文献/References

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EECP对于改善高血压病伴IGT患者血管内皮功能以及PWV的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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