我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

白介素-10基因1 082G/A多态性与急性冠脉综合征的关联性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第6期
页码:
693-696
栏目:
临床研究
出版日期:
2014-06-25

文章信息/Info

Title:
Association between interleukin-10 gene 1 082G/A polymorphism and acute coronary syndrome
作者:
钱志宏; 倪 悦; 李银福; 史雷忠; 蒋 俊; 颜玲玲
(溧阳市人民医院心内科，江苏 溧阳 213300)
Author(s):
QIAN Zhi-hong;  NI Yue;  LI Yin-fu;  SHI Lei-zhong;  JIANG Jun;  YAN Ling-ling
(Department of Cardiology, Liyang People’s Hospital, Liyang 213300, Jiangsu, China)
关键词:
急性冠脉综合征; 白介素-10; 基因多态性
Keywords:
acute coronary syndrome;  interleukin-10;  gene polymorphism
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨常州地区汉族人群白介素-10（IL-10）基因1 082G/A多态性与急性冠脉综合征(ACS)的关联性。方法： ACS组471例，对照组197例，采用基因测序技术检测基因型，并调查相关因素和测定血脂。结果： IL-10基因1 082G/A中在ACS组和对照组中均存在GG、AG和AA 3种基因型；与对照组相比，3种基因型分布频率、等位基因分布频率均无统计学差异；调整对多个危险因素行多元Logistic回归分析，示IL-10基因1 082G/A 3种基因型与ACS的发病仍无相关性。结论： IL-10基因1 082G/A 多态性与常州地区汉族人群ACS的发病无关联。
Abstract:
AIM:To investigate the association between interleukin-10 (IL-10) gene 1 082G/A polymorphism and acute coronary syndrome (ACS) in Chinese Han population of the Changzhou region of Southern Jiangsu. METHODS: Four hundred and seventy-one ACS patients and 197 control subjects were recruited in the study. The polymorphism was genotyped by gene sequencing. RESULTS: GG, AG and AA existed in both ACS group and control group. Compared with those in control group, genotypes and alleles in ACS group showed no statistical differences and multivariate logistic regression analysis also showed no correlation. CONCLUSION: The IL-10 gene polymorphism is not associated with ACS in Chinese Han population of Changzhou region of Southern Jiangsu.

参考文献/References

[1]Heinisch RH,Zanetti CR,Comin F,et al.Serial changes in plasma levels of cytokines in patients with coronary artery disease[J].Vasc Health Risk Manag, 2005,1(3):245-250.
[2]Trompet S,Pons D,DE Craen AJ,et al.Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study[J].Ann N Y Acad Sci,2007,1100:189-198.
[3]张国忠.白细胞介素-1,10及肿瘤坏死因子基因多态性与脑梗塞相关性研究[D].广州:第一军医大学,2006.
[4]Malisan F,Brière F,Bridon JM,et al.Interleukin-10 induces immunoglobulin G isotype Switch recombination in human CD40-activated naive B lymphocytes[J].J Exp Med,1996,183(3):937-947.
[5]Yao I,Huang K,Huang D,et al.Acute myocardial infarction induced increases in plasma tumor necrosis factor-ɑ and interleukin-10 are associated with the e activation of poly(ADP-rebose)polymerase of circulation mononuclear cell[J].Int J Cardial,2008,123(3):366-368.
[6]罗 程，吉庆伟，刘 伶，等.冠心病患者血浆白细胞介素-35、白细胞介素-10及转化生长因子-β_1水平的变化和意义[J].临床心血管病杂志,2012, 28(12):919-921.
[7]Turner DM,Williams DM,Sankaran D,et al.An investigation of polymorphism in the interleukin-10 gene promoter[J].Eur J Immunoqenet,1997,24(1):1-8.
[8]Olivieri F,Antonicclli R,Cardelli M,et al.Genetic polymorphisms of inflammatory cytokines and myocardial infarction on in the elderly[J].Mech Ageing Dev,2006,127(6):552-559.
、

备注/Memo

备注/Memo:
收稿日期：2014-03-06.
作者简介：钱志宏，副主任医师，硕士Email:843342884@qq.com
更新日期/Last Update: 2014-07-10