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|本期目录/Table of Contents|

SDF-1/CXCR4信号轴介导的骨髓间充质干细胞治疗心力衰竭的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第6期
页码:
730-733
栏目:
综述
出版日期:
2014-06-25

文章信息/Info

Title:
Research progress in therapy of SDF-1/CXCR4 axis-mediated bone marrow mesenchymal stem cells for heart failure
作者:
郑 栋 综述; 郭 军 审校
(暨南大学附属第一医院心血管内科，广东 广州 510630）
Author(s):
ZHENG Dong;  GUO Jun
(Department of Cardiology, First Affiliated Hospital, Jinan University, Guangzhou 510630, Guangdong, China)
关键词:
SDF-1/CXCR4信号轴; 心力衰竭; 骨髓间充质干细胞
Keywords:
SDF-1/CXCR4 axis;  heart failure;  bone marrow mesenchymal stem cell therapy
分类号:
R541.61
DOI:
-
文献标识码:
A
摘要:
心力衰竭（heart failure，HF）是由多种心血管疾病所致心脏泵血功能障碍的一类临床常见危重症。目前逐渐兴起的骨髓间充质干细胞(BMMSCs)移植对HF的治疗带来希望，但由于植入细胞存活率低、迁移能力及心肌修复能力弱而削弱了其治疗效应。通过激活基质细胞衍生因子1/CXC族趋化因子受体4(SDF-1/CXCR4)信号轴可有效地解决上述问题。因此，SDF-1/CXCR4信号轴介导的BMMSCs移植可能成为HF治疗的新方向。
Abstract:
Heart failure (HF), a clinically common serious syndrome caused by many cardiovascular diseases, often leads to abnormal cardiac function of pumping blood. Recently, an emerging therapy of bone marrow mesenchymal stem cell implantation offers hope for treatment of HF. However, poor survival of engrafted cells, weak ability of migration and myocardial repair attenuate its positive effects. These problems could be solved via activating SDF-1/CXCR4 axis and thus SDF-1/CXCR4 axis-mediated bone marrow mesenchymal stem cells may be a new line of therapy for HF.

参考文献/References

[1]Rodrigo SF,van Ramshorst J,Hoogslag GE,et al.Intramyocardial injection of autologous bone marrow-derived ex vivo expanded mesenchymal stem cells in acute myocardial infarction patients is feasible and safe up to 5 years of follow-up[J].J Cardiovasc Transl Res,2013,6(5):816-825.
[2]Liu X,Duan B,Cheng Z,et al.SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion[J].Protein Cell,2011, 2(10):845-854.
[3]杨志峰，杨清玲，陈昌杰.趋化因子SDF-1与受体CXCR4的研究进展[J].分子诊断与治疗杂志,2011,(01):58-61.
[4]Dong F,Harvey J,Finan A,et al.Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction[J].Circulation,2012,126(3):314-324.
[5]Post S,van den Broek AJ,Rensing BJ,et al.Reduced CD26 expression is associated with improved cardiac function after acute myocardial infarction:insights from the REPERATOR study[J].J Mol Cell Cardiol,2012,53(6):899-905.
[6]Kanki S,Segers VF,Wu W,et al.Stromal cell-derived factor-1 retention and cardioprotection for ischemic myocardium[J].Circ Heart Fail,2011,4(4):509-518.
[7]Wong D,Korz W.Translating an antagonist of chemokine receptor CXCR4:from bench to bedside[J].Clin Cancer Res,2008,14(24):7975-7980.
[8]Wang K,Zhao X,Kuang C,et al.Overexpression of SDF-1alpha enhanced migration and engraftment of cardiac stem cells and reduced infarcted size via CXCR4/PI3K pathway[J].PLoS One,2012,7(9):e43922.
[9]Larocca TJ,Jeong D,Kohlbrenner E,et al.CXCR4 gene transfer prevents pressure overload induced heart failure[J].J Mol Cell Cardiol,2012,53(2):223-232.
[10]Wu Y,Zhao RC.The role of chemokines in mesenchymal stem cell homing to myocardium[J].Stem Cell Rev,2012,8(1):243-250.
[11]黎叶飞,盛祖龙,姚玉宇,等.两种骨髓间充质干细胞移植途径治疗急性心肌梗死的比较研究[J].东南大学学报(医学版),2011,(05):687-691.
[12]Ghadge SK,Muhlstedt S,Ozcelik C,et al.SDF-1alpha as a therapeutic stem cell homing factor in myocardial infarction［J］. Pharmacol Ther, 2011, 129(1):97-108.
[13]Shen L, Gao Y, Qian J, et al. A novel mechanism for endothelial progenitor cells homing:The SDF-1/CXCR4-Rac pathway may regulate endothelial progenitor cells homing through cellular polarization[J].Med Hypotheses,2011,76(2):256-258.
[14]Yin Q,Jin P, Liu X,et al.SDF-1alpha inhibits hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells through PI3K/Akt and ERK1/2 signaling pathways[J].Mol Biol Rep,2011,38(1):9-16.
[15]Herberg S,Shi X,Johnson MH,et al.Stromal cell-derived factor-1beta mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells[J].PLoS One,2013,8(3):e58207.
[16]Li Z,Guo J,Chang Q,et al.Paracrine role for mesenchymal stem cells in acute myocardial infarction[J].Biol Pharm Bull,2009,32(8):1343-1346.
[17]Tang JM,Wang JN,Zhang L,et al.VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart[J].Cardiovasc Res,2011,91(3):402-411.
[18]Choi SC,Kim SJ,Choi JH,et al.Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways[J].Stem Cells Dev,2008,17(4):725-736.
[19]Li Z,Guo X,Guan J.A thermosensitive hydrogel capable of releasing bFGF for enhanced differentiation of mesenchymal stem cell into cardiomyocyte-like cells under ischemic conditions[J]. Biomacromolecules,2012,13(6):1956-1964.
[20]Chen J,Chemaly E,Liang L,et al.Effects of CXCR4 gene transfer on cardiac function after ischemia-reperfusion injury[J].Am J Pathol,2010,176(4):1705-1715.
[21]Chu PY,Mariani J,Finch S,et al.Bone marrow-derived cells contribute to fibrosis in the chronically failing heart[J].Am J Pathol,2010,176(4):1735-1742.

备注/Memo

备注/Memo:
收稿日期：2013-11-08.
基金项目：国家自然科学基金青年项目资助（81100078）；教育部科学研究重点项目资助（211207）；广州珠江科技 新星资助计划项目资助（2012J2200063）；广东省科技厅博士启动项目资助（S2011040001392） 通讯作者：郭军，副主任医师，主要从事心血管病学研究Email:dr.guojun@163.com
作者简介：郑栋，硕士生Email:changlinclark@foxmail.com
更新日期/Last Update: 2014-07-10