内质网应激与酒精性心肌病的关系研究进展
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2014年第6期
- 页码:
- 737-739743
- 栏目:
- 综述
- 出版日期:
- 2014-06-25
文章信息/Info
- Title:
- Research progress in the relationship between endoplasmic reticulum stress and alcoholic cardiomyopathy
- Author(s):
- QI Xin-tong; LIU Yue; YIN Xin-hua
- （Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China）
- 分类号:
- R542.2
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 近年来，随着酒精性饮品的摄入增加，酒精性心肌病（ACM）的发病率和死亡率也增加。研究发现ACM发病涉及多层次和水平的调控。而且，细胞信号调控的关键场所内质网应激(ERS)在ACM中的作用受到重视。因此，本文对ACM的概述、发病机制以及ERS在酒精所致心肌损伤中的作用进行简要综述。
- Abstract:
- In recent years, morbidity and mortality due to alcoholic cardiomyopathy (ACM) have augmented with the increasing intake of alcoholic beverages. It is confirmed that the development of ACM involves the regulation of multiple factors. Moreover, endoplasmic reticulum stress, which is the key regulatory site of cell signaling, is documented to take part in the development of ACM. In this article we briefly review the overview, pathogenesis of ACM and role of endoplasmic reticulum stress in myocardial injury of alcohol consumption.
参考文献/References
[1]Plunk AD,Syed-Mohammed H,Cavazos-Rehg P,et al.Alcohol consumption,heavy drinking,and mortality:rethinking the j-shaped curve[J].Alcohol Clin Exp Res,2014,38(2):471-478.
[2]George A,Figueredo VM.Alcoholic cardiomyopathy: a review[J].J Card Fail,2011,17(10):844-849.
[3]Tan Y,Li X,Prabhu SD,et al.Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner[J].J Am Coll Cardiol,2012,59(16):1477-1486.
[4]Zhang RH,Gao JY,Guo HT,et al.Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis[J].Biochim Biophys Acta,2013,1832(1):128-141.
[5]Jing L,Jin CM,Li SS,et al.Chronic alcohol intake-induced oxidative stress and apoptosis:role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy[J].Mol Cell Biochem,2012,359(1/2):283-292.
[6]Law BA,Carver WE.Activation of cardiac fibroblasts by ethanol is blocked by TGF-β inhibition[J].Alcohol Clin Exp Res,2013,37(8):1286-1294.
[7]Walter P,Ron D.The unfolded protein response:from stress pathway to homeostatic regulation[J].Science,2011,334(659):1081-1086.
[8]Mozzini C,Fratta Pasini A,Garbin U,et al.Increased endoplasmic reticulum stress and Nrf2 repression in peripheral blood mononuclear cells of patients with stable coronary artery disease[J].Free Radic Biol Med,2014, 68:178-185.
[9]Tsukano H,Gotoh T,Endo M,et al.The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques[J].Arterioscler Thromb Vasc Biol,2010,30(10):1925-1932.
[10]Yu L,Lu M,Wang P,et al.Trichostatin a ameliorates myocardial ischemia/reperfusion injury through inhibition of endoplasmic reticulum stress-induced apoptosis[J].Arch Med Res,2012,43(3):190-196.
[11]Gong W,Duan Q,Cai Z,et al.Chronic inhibition of cGMP-specific phosphodiesterase 5 suppresses endoplasmic reticulum stress in heart failure[J].Br J Pharmacol,2013,170(7):1396-1409.
[12]Lakshmanan AP,Harima M,Suzuki K,et al.The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins[J].Int J Biochem Cell Biol,2013,45(2):438-447.
备注/Memo
- 备注/Memo:
- 收稿日期：2014-02-10.通讯作者：尹新华，教授，主要从事冠心病和心力衰竭研究Email:xinhua_yin@163.com
作者简介：齐欣彤，硕士生Email:tonger521ha812@126.com
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