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|本期目录/Table of Contents|

硫酸镁协同胺碘酮转复室性心动过速的疗效分析

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第1期
页码:
62-063,067
栏目:
临床研究
出版日期:
2014-09-25

文章信息/Info

Title:
Efficacy of magnesium sulfate combined with amiodarone in treatment of refractory ventricular tachycardia
作者:
王学莉1; 伏 添1; 王成立1; 张西京2
(1.汉中3201医院ICU，陕西 汉中 723000；
2.第四军医大学西京医院SICU，陕西 西安 710032)
Author(s):
WANG Xue-li1;  FU Tian1;  WANG Cheng-li1;  ZHANG Xi-jing2
(1.Intensive Care Unit, 3201 Hospital, Hanzhong 723000, Shaanxi, China;
2.Surgical Intensive Care Unit, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
心动过速; 室性; 心律转复; 硫酸镁; 胺碘酮
Keywords:
magnesium sulfate;  amiodarone;  ventricular tachycardia;  cardioversion
分类号:
R541.7
DOI:
-
文献标识码:
A
摘要:
目的:分析硫酸镁协同胺碘酮转复室性心动过速的疗效。方法： 回顾性分析ICU中136例室性心动过速患者，按是否联用硫酸镁将患者分成联合用药组（n=72）和对照组（n=64），分析硫酸镁协同胺碘酮的复律效果。结果： 两组患者基本情况、电转复能量、胺碘酮的负荷量及28 d病死率等比较均无统计学差别；联合用药组电转复次数［(1.4±0.9)次 vs.(3.0±2.2)次，P<0.01］和胺碘酮维持总剂量［(0.9±0.6) g vs.(2.3±1.2) g，P<0.01］显著低于对照组， 30 min转复率（33% vs. 9%，P<0.01）、24 h转复率（97% vs. 78%，P<0.01）及72 h维持成功率（97% vs. 84%，P<0.01）均显著高于对照组；联合用药组2h转复率高于对照组（81% vs. 62%，P<0.05），住ICU时间短于对照组［(7.4±3.9) d vs.(9.1±5.2) d，P<0.05）。结论： 硫酸镁联合胺碘酮转复室性心动过速的疗效优于单用胺碘酮。
Abstract:
AIM:To evaluate the efficacy of magnesium sulfate combined with amiodarone in the treatment of refractory ventricular tachycardia. METHODS: One hundred and thirty-six ICU patients with ventricular tachycardia were retrospectively analyzed. Patients were divided into two groups: magnesium sulfate group with treatment of magnesium sulfate combined with amiodarone (n=72) and amiodarone group (n=64) with treatment of amiodarone only. The cardioversion efficacy of magnesium sulfate was evaluated. RESULTS: There was no difference in aspects such as electric power, load dose of amiodarone and 28-day mortality rate between groups. The times of electric cardioversion ［(1.4±0.9) times vs.(3.0±2.2) times, P<0.01］ and the maintenance dose of amiodarone ［(0.9±0.6) g vs.(2.3±1.2) g, P<0.01］ in the magnesium sulfate group were significantly lower than those in the amiodarone group. The success rate of cardioversion in 30 min (33% vs. 9%, P<0.01) and 24 h (97% vs. 78%, P<0.01) and the rate of maintaining success for 72 h (97% vs. 84%, P<0.01) in the magnesium sulfate group were significantly higher than those in the amiodarone group. The success rate of cardioversion in 2 h in the magnesium sulfate group was higher than in the amiodarone group (81% vs. 62%, P<0.01). The period of ICU stay in the magnesium sulfate group was shorter than in the amiodarone group ［(7.4±3.9) days vs.(9.1±5.2) days, P<0.05］. CONCLUSION: Magnesium sulfate combined with amiodarone has good efficacy for cardioversion and a high rate of maintaining success in patients with refractory ventricular tachycardia.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2014-01-20.
通讯作者：张西京，副教授，主要从事心脑血管保护研究Email：zhangxj918@163.com
作者简介：王学莉,硕士生Email：xlwang3201@sina.cn
更新日期/Last Update: 2015-01-20