通心络对糖尿病并发动脉粥样硬化大鼠心脏功能的影响
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2015年第2期
- 页码:
- 130-133
- 栏目:
- 基础研究
- 出版日期:
- 2014-10-25
文章信息/Info
- Title:
- Effect of tongxinluo on cardiac function in diabetic rats with atherosclerosis
- Author(s):
- YU Lu-jiao1; ZHANG Zi-xin1; JI Xiao1; MU Cui-cui1; ZHANG Li-min2; LI Sha1
- (1.Department of Cardiovasculogy, 2.Department of Ultrasound, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China)
- 分类号:
- R541.4
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的:评价通心络对于糖尿病并发动脉粥样硬化大鼠的血管内皮功能和心脏保护作用。方法:取25只雄性Wistar大鼠，其中20只经尾静脉注射链脲佐菌素和高脂饮食制备糖尿病并发动脉粥样硬化大鼠模型。成模后随机分为单纯模型组和通心络组，单纯模型组给予生理盐水灌胃6周,通心洛组给予通心络超微粉水溶液1 g/(kg·d)灌胃治疗6周,另外5只大鼠给予普通饲料作为正常组。治疗结束后行心脏超声检查，并检测血管性假血友病因子(vWF)和内皮素-1(ET-1)，同时取左室心肌组织进行病理学检查。结果:①超声结果显示，与正常组相比，单纯模型组和通心络组大鼠的室间隔厚度(IVST)、左室后壁厚度(LVPWT)、左室舒张末内径( LVEDD)、左室收缩末内径(LVESD)和左室质量指数(LVMI) 显著增大(均P<0.05)；通心络组的上述指标比单纯模型组均显著降低(P<0.05)。②生化检验结果显示单纯模型组的vWF和ET-1比正常组显著增加(均P<0.05)，通心络组的vWF和ET-1水平低于单纯模型组(均P<0.05)，略高于正常组(无统计学差异)。③病理学结果示与正常组相比，单纯模型组和通心络组都出现间质水肿、心肌坏死；但通心络组病变程度比模型组轻。结论:糖尿病并发动脉粥样硬化大鼠存在内皮损伤，心室重构。通心络可以抑制心室重构，保护心肌组织，改善血管内皮功能。
- Abstract:
- AIM:To assess the cardioprotection and protective effect of vascular endothelium of tongxinluo on diabetic rats with atherosclerosis. METHODS: A total of 25 male Wistar rats were included. Five rats were kept as the normal control group; 20 were injected with streptozotocin (STZ) by caudal vein and fed a hyperlipid diet to obtain a diabetic rat model with atherosclerosis. Then, rat models were divided randomly into two groups: model group and tongxinluo group. Saline and tongxinluo aqueous solution were given separately by gavage for 6 weeks according to group type. In the end, echocardiogram test was manipulated on rats and blood was collected for testing of vWF and ET-1. Myocardial tissues were used for pathogenic test. RESULTS: Ultrasound showed that compared to normal control group, model group and tongxinluo group IVST, LVPWT, LVEDD, LVESD and LVMI were higher (P<0.05); whereas compared to model group, all the above indexes in the tongxinluo group were lower (P<0.05). For vWF and ET-1 test, model group is higher than normal group (P<0.05), whereas the tongxinluo group is lower than the model group (P<0.05) and slightly higher than in the normal group (P>0.05). Pathological examination showed myocardial congestion, swelling and necrosis in the model group and tongxinluo group with the lesions in the tongxinluo group being less severe. CONCLUSION: Endothelial injury and ventricular remodeling occurs in diabetic rats with atherosclerosis. Tongxinluo can inhibit ventricular remodeling and improve vascular endothelial function.
参考文献/References
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备注/Memo
- 备注/Memo:
- 收稿日期：2014-07-28.
基金项目：辽宁省自然科学基金项目资助（20092109）
通讯作者：张子新，副主任医师，主要从事冠心病与血管内皮功能研究 Email：catexin2000@qq.com
作者简介：余陆娇，住院医师，硕士 Email：yljbetty@qq.com
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