应用64层螺旋CT评价阿托伐他汀治疗效果的价值
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2015年第2期
- 页码:
- 202-205
- 栏目:
- 临床研究
- 出版日期:
- 2014-10-25
文章信息/Info
- Title:
- Effect of atorvastatin on computed tomography attenuation value of coronary plaques
- Author(s):
- ZHOU Yi; CHEN Man-hua; XIONG Cai-jin; YANG Kai; HE Qin; CHEN Gang
- (Department of Cardiology, Wuhan Central Hospital, Wuhan 430014, Hubei, China)
- Keywords:
- statin; coronary; plaque; tomography; spiral computer
- 分类号:
- R445.3
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的:观察应用64层螺旋CT(64-SCT)评价阿托伐他汀治疗效果的价值。方法:回顾性分析阿托伐他汀治疗的36例患者，共计45处非钙化冠脉斑块病变。依据治疗后低密度脂蛋白胆固醇(LDL-C)水平分为达标组(17例，20处病变)和未达标组(19例，25处病变)。比较两组病例血生化指标的变化。比较两组病变血管重构系数、斑块体积、最小管腔直径、斑块平均CT值和最小CT值的变化。结果:达标组LDL-C降幅为47%，大于未达标组的30%(P<0.01)。两组的血管重构系数和斑块体积均可见减小的趋势，但差异均未达到统计学显著水平。与治疗前比较，达标组的斑块平均CT值增加了3.35 Hu(P<0.01)，斑块最小CT值升高了10.95 Hu(P<0.01)。未达标组斑块平均CT值及最小CT值均与基线时相似。结论:阿托伐他汀治疗（LDL-C达标）有利于提高冠脉斑块的稳定性。
- Abstract:
- AIM:To observe the effect of atorvastatin therapy on computed tomography (CT) attenuation value of non-calcified coronary plaques. METHODS: Thirty-six patients with 45 plaques without calcification were analyzed retrospectively. The patients were divided into target-achieving group (17 patients and 20 plaques) and non-target-achieving group (19 patients and 25 plaques) according to the level of low-density lipoprotein cholesterol at follow-up. Changes in serum lipid profile and CT parameters from baseline to follow-up between groups were compared. RESULTS: Reduction of low-density lipoprotein cholesterol in achieving target group and failing to achieve target group were 47% and 30%, respectively. Low-density lipoprotein cholesterol in target-achieving group was significantly lower than that in non-target-achieving group (P<0.01). No significant difference was observed in the changes of remodeling index and plaque volume from baseline to follow-up in both groups. Mean CT attenuation value and minimum CT attenuation value of the coronary plaque increased respectively 3.35 Hu and 10.95 Hu from baseline to follow-up in target-achieving group (P<0.01). Changes of mean CT attenuation value and minimum CT attenuation value of plaques from baseline to follow-up were not significantly different in non-target-achieving group. CONCLUSION: Increase of mean CT attenuation value and minimum CT attenuation value of plaques from baseline to follow-up in target-achieving group may indicate coronary plaque stabilization. Insignificant changes between baseline and follow-up in non-target-achieving group suggest the importance of achieving the therapeutic target of low-density lipoprotein cholesterol.
参考文献/References
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备注/Memo
- 备注/Memo:
- 收稿日期：2014-06-05.
基金项目：武汉市卫生局临床医学科研项目资助（WX12B03）
通讯作者：陈曼华，主任医师，主要从事冠心病临床及基础研究 Email：chenmh@aliyun.com
作者简介：周逸，副主任医师，硕士 Email:coronary@aliyun.com
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