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|本期目录/Table of Contents|

细胞自噬与心血管疾病中炎症反应的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第3期
页码:
340-343
栏目:
综述
出版日期:
2015-01-11

文章信息/Info

Title:
Relationship of autophagy and inflammatory processes of cardiovascular disease
作者:
杨 扬; 赵 美; 赵 铭; 臧伟进
（西安交通大学医学部基础医学院药理学系，陕西 西安 710061）
Author(s):
YANG Yang;  ZHAO Mei;  ZHAO Ming;  ZANG Wei-jin
(Department of Pharmacology, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China)
关键词:
细胞自噬; 炎症; 心血管疾病
Keywords:
autophagy;  inflammation;  cardiovascular disease
分类号:
R392.3
DOI:
-
文献标识码:
A
摘要:
细胞自噬既是保守的细胞防御机制，也是程序性细胞死亡(即调亡)机制，其可维持细胞自身内环境的稳态。心血管疾病多伴有炎症反应并与细胞自噬密切相关。新近研究表明：一方面，自噬可以通过清除堆积蛋白和保持线粒体稳态对抗心血管疾病的炎症反应，此效应可能与抑制炎症小体以及钙蛋白酶依赖的白介素-1α的活性有关；另一方面，自噬在某些情况下也可促进炎症反应，自噬相关蛋白和高尔基体重组-堆叠蛋白参与了自噬的促炎效应。以本文简要综述细胞自噬在心血管疾病炎症反应中的作用，探讨自噬与炎症反应的相关分子机制，为心血管疾病中炎症反应的治疗提供新的思路。
Abstract:
Autophagy, a highly conserved cell degradation process and a programmed cell death process, can maintain intracellular homeostasis. Cardiovascular diseases are accompanied by inflammatory response and are closely related to autophagy. Recent studies reveal that on one hand, autophagy can protect against inflammation in the cardiovascular system through removing accumulated protein and maintaining mitochondria homeostasis. This effect is related to suppressing inflammasome and calpain-dependent IL-1α activation. On the other hand, autophagy can promote inflammatory reaction under some circumstances. ATG factors and a specialized unconventional secretion regulator Golgi reassembly-stacking protein (GRASP) may be involved in this pro-inflammatory effect. This paper reviews the research progress of autophagy in inflammation of cardiovascular disease and discusses related molecular mechanisms between autophagy and inflammation so as to provide some new insight into the treatment of inflammation in cardiovascular diseases.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2014-07-02.
基金项目：国家自然科学基金重大国际(地区)合作项目资助（81120108002）;高等学校博士学科点专项科研基金优先发展领域课题资助（20130201130008）;陕西省自然科学基金项目资助（2012JZ4001）
通讯作者：臧伟进，教授，主要从事心血管药理学研究Email：zwj@mail.xjtu.edu.cn
作者简介：杨扬，硕士生Email：yaya326yaya@163.com
更新日期/Last Update: 2015-02-03