我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

血清白介素15水平与冠心病冠状动脉病变严重程度的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第5期
页码:
569-572
栏目:
临床研究
出版日期:
2015-05-05

文章信息/Info

Title:
Correlation study on serum IL-15 and severity of coronary artery stenosis of coronary heart disease
作者:
尤 菲; 王 磊; 司 瑞; 袁 铭; 郭文怡
（第四军医大学西京医院心血管内科，陕西 西安 710032）
Author(s):
YOU Fei;  WANG Lei;  SI Rui;  YUAN Ming;  GUO Wen-yi
(Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
白介素15; Gensini积分; 冠状动脉粥样硬化; 冠状动脉疾病
Keywords:
interleukin 15;  Gensini score;  coronary atherosclerosis;  coronary artery disease
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 分析血清白介素15(interleukin15，IL-15)水平与冠心病冠状动脉病变严重程度的相关性。方法 选取我院心内科行冠脉造影检查的患者270例，采用 Gensini评分评估冠脉狭窄严重程度，将患者按冠脉狭窄程度分为：正常组、轻度狭窄组、中度狭窄组和重度狭窄组（正常组Gensini=0；轻度组：041）。所有受试者接受问卷调查、体格测量、生化指标、收集各受试者临床资料及采用ELISA测定血清IL-15的浓度。运用多种统计分析方法，采用回归模型校正年龄，体质量指数，血脂，C反应蛋白，高血压病以及糖尿病等混杂因素，分析IL-15水平与冠心病冠脉病变严重程度的相关性。结果 与冠脉造影正常组相比，冠脉狭窄患者血液中IL-15水平显著高于冠脉正常人群，并随冠状动脉狭窄的严重程度增加有逐渐增高的趋势〔正常:(6.7±2.0)ng/L,轻度狭窄:(11.9±3.1) ng/L,中度狭窄:(18.3±3.2) ng/L,重度狭窄:(24.4±4.0) ng/L;P<0.01〕。IL-15与Gensini评分呈正相关（r=0.572，P<0.01），这种关系在校正年龄，体质量指数，C反应蛋白，血脂，高血压病以及糖尿病等混杂因素后依然存在,是独立的相关因素。结论 血清IL-15水平与冠脉狭窄程度呈正相关，血清IL-15水平是冠心病冠脉病变严重程度的独立相关因素。/html>
Abstract:
AIM To assess the relationship between serum IL-15 and severity of coronary artery stenosis. METHODS Enrolled in this study were 270 subjects with suspected coronary heart disease who underwent coronary angiography (CAG). Subjects were divided into normal group, mild group, moderate group and severe group according to the Gensini score (normal: Gensini=0; mild: 041). Clinical data were collected using questionnaires, physical measurements and biochemical indexes and enzyme-linked immunosorbent assay (ELISA) was used to determine serum IL-15 levels. Using multiple statistical analysis methods, we conducted analyses including confounders and regression models adjusted for various measurements such as age, body mass index, lipid, C-reactive protein, hypertension and diabetes mutually for IL-15. RESULTS Compared with those in subjects without coronary stenosis, circulating IL-15 levels were significantly higher in subjects with stenosis with an increasing trend towards the severity of stenosis (normal: (6.7±2.0) pg/ml, mild: (11.9±3.1) pg/ml, moderate: (18.3±3.2) pg/ml, and severe: (24.4±4.0) pg/ml; P<0.01). IL-15 was positively correlated with Gensini score (r=0.572, P<0.01) after adjusting for age, body mass index, lipid, C-reactive protein, hypertension and diabetes and was an independently related factor. CONCLUSION Serum IL-15 is higher in patients with coronary artery stenosis and is positively correlated with the severity of stenosis. These results indicate that serum IL-15 may be an independent related factor of coronary artery stenosis.

参考文献/References

[1] Weissberg PL,Bennett MR.Atherosclerosis--an inflammatory disease[J].N Engl J Med,1999,340(24):1928-1929.
[2]Ridker PM,Rifai N,Pfeffer M,et al.Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction[J].Circulation,2000,101(18):2149-2153.
[3]Ridker PM,Rifai N,Stampfer MJ,et al.Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men[J].Circulation,2000,101(15):1767-1772.
[4]Wensley F,Gao P,Burgess S,et al.Association between C reactive protein and coronary heart disease:mendelian randomisation analysis based on individual participant data[J].BMJ,2011,342:d548.
[5]Houtkamp MA,van Der Wal AC,de Boer OJ,et al.Interleukin-15 expression in atherosclerotic plaques:an alternative pathway for T-cell activation in atherosclerosis[J].Arterioscler Thromb Vasc Biol,2001,21(7):1208-1213.
[6]Wuttge DM,Eriksson P,Sirsjo A,et al.Expression of interleukin-15 in mouse and human atherosclerotic lesions[J].Am J Pathol,2001,159(2):417-423.
[7]Chen J,Chen MH,Li S,et al.Usefulness of the Neutrophil-to-Lymphocyte Ratio in Predicting the Severity of Coronary Artery Disease:A Gensini Score Assessment[J].J Atheroscler Thromb,2014,21(12):1271-1282.
[8]Gensini GG.A more meaningful scoring system for determining the severity of coronary heart disease[J].Am J Cardiol,1983,51(3):606.
[9]Grabstein KH,Eisenman J,Shanebeck K,et al.Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor[J].Science,1994,264(5161):965-968.
[10]Burton JD,Bamford RN,Peters C,et al.A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line,stimulates T-cell proliferation and the induction of lymphokine-activated killer cells[J].Proc Natl Acad Sci U S A,1994,91(11):4935-4939.
[11]Malamut G,El MR,Montcuquet N,et al.IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis[J].J Clin Invest,2010,120(6):2131-2143.
[12]Stemme S,Faber B,Holm J,et al.T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein[J].Proc Natl Acad Sci U S A,1995,92(9):3893-3897.
[13]McInnes IB,al-Mughales J,Field M,et al.The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis[J].Nat Med,1996,2(2):175-182.
[14]Wensley F,Gao P,Burgess S,et al.Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data[J].BMJ,2011,342: d548.
[15]Aune E,Roislien J,Mathisen M,et al.The“smoker’s paradox” in patients with acute coronary syndrome:a systematic review[J].BMC Med,2011,9: 97.

备注/Memo

备注/Memo:
收稿日期：2014-12-16.
通讯作者：郭文怡,主任医师,主要从事冠心病治疗研究Email: guowenyi@tom.com
共同通讯作者：袁铭，副教授，主要从事冠心病介入治疗研究 Email：yuanming@fmmu.edu.cn
作者简介：尤菲,本科生 Email：47453096@qq.com
更新日期/Last Update: 2015-04-28