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|本期目录/Table of Contents|

冠状动脉慢血流患者血清胆红素与抵抗素的含量测定

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第6期
页码:
695-698
栏目:
临床研究
出版日期:
2015-07-15

文章信息/Info

Title:
Determination of serum bilirubin and resistin content in patients with coronary slow flow
作者:
胡艳粉权晓娟李秀丽章 琳闫 玲李领侠
(西安交通大学第二附属医院老年呼吸内分泌科,陕西 西安 710004)
Author(s):
HU Yan-fen QUAN Xiao-juan LI Xiu-li ZHANG Lin YAN Ling LI Ling-xia
(Department of Senile Respiratory Medicine and Endocrinology, Second Affiliated Hospital, Medical College of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China)
关键词:
冠状动脉慢血流血清胆红素抵抗素
Keywords:
coronary slow flow phenomenon serum bilirubin resistin
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨血清胆红素和血清抵抗素与冠状动脉慢血流现象的关系。方法 冠状动脉造影以及TIMI帧数测量确定慢血流患者以及血流正常者分别作为实验组(40例)和对照组(40例)。经过基础资料统计、常规生物化学检验、酶联免疫以及比色法测定并比较两组指标。结果 两组基础资料相当,吸烟率差异较大(P<0.05);血清生物化学检验发现实验组血糖水平稍高于对照组(P<0.05),抵抗素水平明显高于对照组(P<0.05);而血清胆红素水平却远远低于对照组(P<0.01),差异具有统计学意义。结论 血清胆红素水平降低以及吸烟率、抵抗素、血糖水平升高与冠状动脉慢血流关系密切。
Abstract:
AIM To explore the relationship between serum bilirubin, resistin and coronary slow flow phenomenon (CSFP). METHODS Forty patients with CSFP selected by coronary arteriography (CAG) and corrected TIMI frame count (CTFC) were assigned to CSFP group and 40 patients with normal coronary flow to control group. Basic data, normal serum biochemical tests, enzyme-linked immunoassay (ELISA) and colorimetric method were conducted to analyze and compare the indicators of CSFP, with bilirubin and resistin included. RESULTS No significant differences were found in the general data between groups. Compared with those in the control group, the smoking rate and blood glucose level in CSFP group were higher (both P<0.05). Moreover, CSFP possessed a lower concentration of serum bilirubin (P<0.01) and higher resistin (P<0.05) in comparison with those in the control group. CONCLUSION Results demonstrate that a low concentration of serum bilirubin and high smoking rate and high resistin are closely related to CSFP.

参考文献/References

[1]Tambe AA,Demany MA,Zimmerman HA,et al.Angina pectoris and slow flow velocity of dye in coronary arteries--a new angiographic finding[J].Am Heart J,1972,84(1):66-71.
[2]Fineschi M,Gori T.Coronary slow flow:Description of a new“cardiac Y”syndrome[J].Int J Cardiol,2009,137(3):308-310.
[3]上官文锋,李广平.冠状动脉慢血流现象研究进展[J].中国心血管杂志,2013,18(1):66-68.
[4]Minetti M,Mallozzi C,Di Stasi AM,et al.Bilirubin is an effective antioxidant of peroxynitrite-mediated protein oxidation in human blood plasma[J].Arch Biochem Biophys,1998,352(2):165-174.
[5]何 昕,唐艳芳,刘景艳,等.血清胆红素水平与冠心病的相关性[J].中华实用诊断与治疗杂志,2012,26(9):929-931.
[6]兰燕平,蔡天志.血清胆红素水平与冠状动脉狭窄程度的关系[J].西安交通大学学报(医学版),2006,27(5):468-470.
[7]Verma S,Li SH,Wang CH,et al.Resistin promotes endothelial cell activation:Further evidence of adipokine-endothelial interaction[J].Circulation,2003,108(6):736-740.
[8] Kawanami D,Maemura K,Takeda N,et al. Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: A new insight into adipocytokine-endothelial cell interactions[J]. Biochem Biophys Res Commun, 2004, 314(2):415-419.
[9]Beltrame JF,Limaye SB,Horowitz JD.The coronary slow flow phenomenon--a new coronary microvascular disorder[J].Cardiology,2002,97(4):197-202.
[10]拓步雄,李 慧,李超民,等.冠状动脉慢血流现象与血清脂质过氧化水平的关系[J].心脏杂志,2010,22(5):730-732.
[11]刘显初,郑利平,黄胜贤,等.冠心病血清总胆红素与氧化修饰低密度脂蛋白的关系研究[J].中华检验医学杂志,2003,26(8):479-480.
[12]Dekker D,Dorresteijn MJ,Pijnenburg M,et al.The bilirubin-increasing drug atazanavir improves endothelial function in patients with type 2 diabetes mellitus[J].Arterioscler Thromb Vasc Biol,2011,31(2):458-463.
[13]Dick GM,Katz PS,Farias M,et al.Resistin impairs endothelium-dependent dilation to bradykinin, but not acetylcholine, in the coronary circulation[J].Am J Physial Heart Circ Physiol,291(6):H2997-H3002.
[14]Burnett MS,Lee CW,Kinnaird TD,et al.The potential role of resistin in atherogenesis[J].Atherosclerosis,2005,182(2):241-248.

备注/Memo

备注/Memo:
收稿日期:2015-03-23.
通讯作者:李领侠,副主任护师,主要从事老年心血管病和糖尿病健康管理研究 Email:1633529972@qq.com
作者简介:胡艳粉,护师 Email:343580880@qq.com
更新日期/Last Update: 2015-07-23