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|本期目录/Table of Contents|

microRNAs在心脏疾病中的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第1期
页码:
97-101
栏目:
综述
出版日期:
2015-09-15

文章信息/Info

Title:
Research progress of microRNAs in the development of heart disease
作者:
史默怡; 刘 莉; 金 娟; 邹国良; 隋艳波
（黑龙江中医药大学附属第一医院心血管内一科，黑龙江 哈尔滨 150040）
Author(s):
SHI Mo-yi;  LIU Li;  JIN Juan;  ZOU Guo-liang;  SUI Yan-bo
(Department of Cardiology, Affiliated Hospital First, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang, China)
关键词:
心脏疾病; microRNAs; 分子机制
Keywords:
heart disease;  microRNAs;  molecular mechanisms
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
microRNAs(miRNAs)是能够调控基因表达的小核苷酸序列。相关研究表明miRNA可维持体内环境稳态，调控真核细胞的生理功能，参与到多种病理途径过程。许多研究表明，心脏疾病的发生发展与miRNAs的调控息息相关，因而，近年对miRNAs在心脏疾病方面的研究得到迅猛发展。本文对miRNA在心脏疾病中的作用进行了综述，并探讨了相关的分子机制，旨在寻找治疗心脏疾病的新靶点。
Abstract:
MicroRNAs (miRNAs) are small nucleotide sequences that regulate gene expression. Studies show that miRNA can maintain body homeostasis, regulate the physiological function of eukaryotic cells, and participate in a variety of pathological pathways. Many studies prove that miRNAs play an important role in heart disease. Recent research of miRNAs aimed at finding new targets for the treatment of heart disease has achieved rapid development. This paper systematically reviews the functions of miRNAs in heart disease and discusses the related molecular mechanisms.

参考文献/References

[1]Da Sacco L,Masotti A.Recent insights and novel bioinformatics tools to understand the role of MicroRNAs binding to 5′ untranslated region[J].Int J Mol Sci,2012,14(1):480-495.
[2]Kozomara A,Griffiths-Jones S.miRBase:integrating microRNA annotation and deep-sequencing data[J].Nucleic Acids Res,2011,39(Database issue):D152-D157.
[3]Berezikov E.Evolution of microRNA diversity and regulation in animals[J].Nat Rev Genet,2011,12(12):846-860.
[4]Bernardo BC,Charchar FJ,Lin RC,et al.A microRNA guide for clinicians and basic scientists:background and experimental techniques[J].Heart Lung Circ,2012,21(3):131-142.
[5]Nilsen TW.Mechanisms of microRNA-mediated gene regulation in animal cells[J].Trends Genet,2007,23(5):243-249.
[6]Chan JA,Krichevsky AM,Kosik KS.MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells[J]. Cancer Res,2005,65(14):6029-6033.
[7]Karunakaran D,Rayner KJ.MicroRNAs in cardiovascular health:from order to disorder[J].Endocrinology,2013,154(11):4000-4009.
[8]Skommer J,Rana I,Marques FZ,et al.Small molecules,big effects:the role of microRNAs in regulation of cardiomyocyte death[J].Cell Death Dis,2014,5(5):e1325.
[9]Tang Y,Wang MH.MicroRNA-21 protects cardiomyocytes from tumor necrosis factor-α induced apoptosis in vitro via modulating PTEN/AKT/FOXO3a pathway[J].Zhonghua Xin Xue Guan Bing Za Zhi,2013,41(2):135-142.
[10]Long B,Wang K,Li N,et al.miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor[J].Free Radic Biol Med,2013,65:371-379.
[11]Bridge G,Monteiro R,Henderson S,et al.The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis[J].Blood,2012,120(25):5063-5072.
[12]Xu C,Hu Y,Hou L,et al.β-Blocker carvedilol protects cardiomyocytes against oxidative stress-induced apoptosis by up-regulating miR-133 expression[J].J Mol Cell Cardiol,2014,75:111-121.
[13]He S,Liu P,Jian Z,et al.miR-138 protects cardiomyocytes from hypoxia-induced apoptosis via MLK3/JNK/c-jun pathway[J].Biochem Biophys Res Commun,2013,441(4):763-769.
[14]Mckinsey TA,Olson EN.Toward transcriptional therapies for the failing heart:chemical screens to modulate genes[J].J Clin Invest,2005,115(3):538-546.
[15]Pan ZW,Lu YJ,Yang BF.MicroRNAs:a novel class of potential therapeutic targets for cardiovascular diseases[J].Acta Pharmacol Sin,2010,31(1):1-9.
[16]van Rooij E,Sutherland LB,Liu N, et al.A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure[J].Proc Natl Acad Sci U S A,2006,103(48):18255-18260.
[17]van Rooij E,Sutherland LB,Qi X,et al.Control of stress-dependent cardiac growth and gene expression by a microRNA[J].Science,2007,316(5824):575-579.
[18]Ikeda S,He A,Kong SW,et al.MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes[J].Mol Cell Biol,2009,29(8):2193-2204.
[19]Sayed D,Hong C,Chen IY,et al.MicroRNAs play an essential role in the development of cardiac hypertrophy[J].Circ Res,2007,100(3):416-424.
[20]Carè A,Catalucci D,Felicetti F,et al.MicroRNA-133 controls cardiac hypertrophy[J].Nat Med,2007,13(5):613-618.
[21]Shen E,Diao X,Wang X,et al.MicroRNAs involved in the mitogen-activated protein kinase cascades pathway during glucose-induced cardiomyocyte hypertrophy[J].Am J Pathol,2011,179(2):639-650.
[22]van Rooij E,Sutherland LB,Thatcher JE,et al.Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis[J].Proc Natl Acad Sci U S A,2008,105(35):13027-13032.
[23]Kwiecinski M,Noetel A,Elfimova N,et al.Hepatocyte growth factor(HGF)inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction[J].PLoS One,2011,6(9):e24568.
[24]Marfella R,Di Filippo C,Potenza N,et al.Circulating microRNA changes in heart failure patients treated with cardiac resynchronization therapy:responders vs.non-responders[J].Eur J Heart Fail,2013,15(11):1277-1288.
[25]Roy S,Khanna S,Hussain SR,et al.MicroRNA expression in response to murine myocardial infarction:miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue[J].Cardiovasc Res,2009,82(1):21-29.
[26]Thum T,Gross C,Fiedler J,et al.MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts[J].Nature,2008,456(7224):980-984.
[27]Thum T,Galuppo P,Wolf C,et al.MicroRNAs in the human heart:a Clue to fetal gene reprogramming in heart failure[J].Circulation,2007,116(3):258-267.
[28]Jessup M,Greenberg B,Mancini D,et al.Calcium upregulation by percutaneous administration of gene therapy in cardiac disease(CUPID):a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure[J].Circulation,2011,124(3):304-313.
[29]Kumarswamy R,Lyon AR,Volkmann I,et al.SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway[J].Eur Heart J,2012,33(9):1067-1075.
[30]Wahlquist C,Jeong D, Rojas-Mu?oz A,et al.Inhibition of miR-25 improves cardiac contractility in the failing heart[J].Nature,2014,508(7497):531-535.
[31]Endo K,Naito Y,Ji X,et al.MicroRNA 210 as a biomarker for congestive heart failure[J].Biol Pharm Bull,2013,36(1):48-54.
[32]Porrello ER.microRNAs in cardiac development and regeneration[J].Clin Sci,2013,125(4):151-166.
[33]Dong S,Cheng Y,Yang J,et al.MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction[J].J Biol Chem,2009,284(43):29514-29525.
[34]Yin C,Salloum FN,Kukreja RC.A novel role of microRNA in late preconditioning: upregulation of endothelial nitric oxide synthase and heat shock protein 70[J].Circ Res,2009,104(5):572-575.
[35]Ren XP,Wu J,Wang X,et al.MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20[J].Circulation,2009,119(17):2357-2366.
[36]Bonauer A,Carmona G,Iwasaki M,et al.MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice[J].Science,2009,324(5935):1710-1713.
[37]Zernecke A,Bidzhekov K,Noels H,et al.Delivery of microRNA-126 by apoptotic bodies induces CXCL12- dependent vascular protection[J].Sci Signal,2009,2(100):ra81.
[38]Chan YC,Roy S,Huang Y,et al.The microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway[J].Biol Chem,2012,287(49):41032-41043.

备注/Memo

备注/Memo:
收稿日期：2014-10-15.
通讯作者：刘莉，副主任医师，主要从事心血管疾病研究 Email:30911392@qq.com
作者简介：史默怡，博士生 Email:leisisibin@126.com
更新日期/Last Update: 2015-09-16