我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

低温诱发高血压机制的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第1期
页码:
107-109,122
栏目:
综述
出版日期:
2015-09-15

文章信息/Info

Title:
Advances in mechanisms of cold-induced hypertension
作者:
郑丽霞; 尹 崑; 蔡本志
(哈尔滨医科大学药学院药理教研室，黑龙江 哈尔滨 150081)
Author(s):
ZHENG Li-xia;  YIN Kun;  CAI Ben-zhi
(Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150081, Heilongjiang, China)
关键词:
低温暴露; 高血压; 分子机制
Keywords:
low temperature exposure;  hypertension;  molecular mechanism
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
高血压是最常见的心血管疾病，是心肌肥厚、心力衰竭等心脏疾病发生的重要危险因素。近年来，越来越多的研究者关注低温暴露对高血压影响这一研究领域并取得了一系列进展，本文归纳总结了低温暴露诱发及加重高血压的相关机制，主要包括低温暴露对神经内分泌系统、大电导钙激活钾通道(BKCa)、氧化应激反应、内皮功能、炎症反应及盐皮质激素受体这几方面的影响。通过探讨其病理机制为寻找其预防治疗措施提供理论参考。
Abstract:
Hypertension is a common cardiovascular disease and a major public health problem worldwide. In recent years, more and more investigators have focused attention on the influence of low temperature on hypertension and achieved progress in this research. In this paper we review the related mechanism of low temperature-induced and aggravated hypertension, including neuroendocrine, BKCa, oxidative stress, endothelial function, inflammation, and mineralocorticoid receptor. The discussion of its pathological mechanism will provide the theoretical basis for prevention and treatment.

参考文献/References

[1]Wang J,Zhang L,Wang F,et al.Prevalence, awareness, treatment, and control of hypertension in China:results from a National survey[J].Am J Hypertens,2014,27(11):1355-1361.
[2]Su D,Du H,Zhang X,et al.Season and outdoor temperature in relation to detection and control of hypertension in a large rural Chinese population[J].Int J Epidemiol,2014,43(6):1835-1845.
[3]Deshmukh A,Pant S,Kumar G,et al.Seasonal variation in hypertensive emergency hospitalization[J].J Clin Hypertens(Greenwich),2012,14(4):269-270.
[4]Miersch A,Vogel M,Gausche R,et al.Influence of seasonal variation on blood pressure measurements in children, adolescents and young adults[J].Pediatr Nephrol,2013,28(12):2343-2349.
[5]Hozawa A,Kuriyama S,Shimazu T,et al.Seasonal variation in home blood pressure measurements and relation to outside temperature in Japan[J].Clin Exp Hypertens,2011,33(3):153-158.
[6]于长青,祝之明,王利娟,等.冷应激高血压大鼠血管舒缩功能的研究[J].高血压杂志, 2002,10(2):163-165.
[7]Luo B,Zhang S,Ma S,et al.Artificial cold air increases the cardiovascular risks in spontaneously hypertensive rats[J].Int J Environ Res Public Health,2012,9(9):3197-3208.
[8]Sun Z,Cade R,Morales C.Role of central angiotensin II receptors in cold-induced hypertension[J].Am J Hypertens,2002,15(1 Pt 1):85-92.
[9]Sun Z,Cade R,Zhang Z,et al.Angiotensinogen gene knockout delays and attenuates cold-induced hypertension[J].Hypertension,2003,41(2):322-327.
[10]Sun Z,Wang X,Wood CE,et al.Genetic AT1A receptor deficiency attenuates cold-induced hypertension[J].Am J Physiol Regul Integr Comp Physiol,2005,288(2):R433-R439.
[11]Wang X,Sun Z,Cade R. Prolonged attenuation of cold-induced hypertension by adenoviral delivery of renin antisense[J].Kidney Int,2005,68(2):690-687.
[12]王凌云,郑 杨.大电导钙激活钾通道的血管扩张作用[J].中国心血管杂志,2005,10(2):155-157.
[13]阚敬保,杨玉雯.BKCa通道的舒血管机制[J].中国心血管病研究,2007,5(12):949-952.
[14]Wang YX,Zhang SH,Ge YZ,et al.GW24-e0445 role of BKCa channels in vascular smooth muscle during the development of environmental cold-induced hypertension[J].Heart,2013,99(Suppl 3):A80.
[15]Martarelli D,Cocchioni M,Scuri S,et al.Cold exposure increases exercise-induced oxidative stress[J].J Sports Med Phys Fitness, 2011,51(2):299-304.
[16]石红梅,何丽华,张 颖,等.一氧化氮和一氧化氮合酶在冷应激性高血压形成中的变化[J].中华劳动卫生职业病杂志,2007,25(4):197-199.
[17]王全伟,凡文博,王智昊,等.氧化应激与心血管疾病关系的研究进展[J].中国老年学杂志,2014(1):270-273.
[18]文海若,李 波,付 研.血管紧张素Ⅱ在心血管疾病中的氧化应激调节机制[J].中国医刊,2014,49(2):12-14.
[19]Wang X,Skelley L,Wang B,et al.AAV-based RNAi silencing of NADPH oxidase gp91(phox) attenuates cold-induced cardiovascular dysfunction[J].Hum Gene Ther,2012,23(9):1016-1026.
[20]Chen GF,Sun Z.Effects of chronic cold exposure on the endothelin system[J].J Appl Physiol(1985),2006,100(5):1719-1726.
[21]Zhu Z,Zhu S,Zhu J,et al.M.Endothelial dysfunction in cold-induced hypertensive rats[J].Am J Hypertens,2002,15(2 Pt 1):176-180.
[22]周 颖,陈 虹.血管内皮细胞功能紊乱与心血管疾病关系的研究进展[J].现代生物医学进展,2006,6(8):63-65.
[23]Nakano D,Pollock D.New concepts in endothelin control of Sodium balance[J].Clin Exp Pharmacol Physiol,2012,39(1):104-110.
[24]Abassi ZA,Ellahham S,Winaver J,et al.The intrarenal endothelin system and hypertension[J].Physiology,2001,16(4):152-156.
[25]Chen GF,Sun Z.Effects of chronic cold exposure on the endothelin system[J].Journal of Applied Physiology,2006,100(5):1719-1726.
[26]Wang X,Skelley L,Cade R,et al.AAV delivery of mineralocorti-coid receptor shRNA prevents progression of cold-induced hypertension and attenuates renal damage[J].Gene Ther,2006,13(14):1097-1103.
[27]Sun Z,Bello-Roufai M,Wang X.RNAi inhibition of mineralocorticoid receptors prevents the development of cold-induced hypertension[J].Am J Physiol Heart Circ Physiol,2008,294(4):H1880-H1887.
[28]姜冬梅,李士泽,杨焕民,等.冷应激家兔血压与血清细胞因子的变化及其相互关系［J］. 环境与健康杂志, 2007, 24(8):577-580.
[29]Crosswhite P, Sun Z. Ribonucleic acid interference knockdown of interleukin 6 attenuates cold-induced hypertension[J].Hypertension, 2010,55(6):1484-1491.
[30]Bautista LE.Inflammation,endothelial dysfunction,and the risk of high blood pressure:epidemiologic and biological evidence[J].Journal of human hypertension,2003,17(4):223-230.

备注/Memo

备注/Memo:
收稿日期：2014-09-18.
通讯作者：蔡本志，教授，主要从事心血管疾病防治研究 Email：caibz@foxmail.com
作者简介：郑丽霞，本科生 Email：1090236329@qq.com
作者简介：沙莉，副主任医师，硕士 Email：lilisha5000@sina.com
更新日期/Last Update: 2015-09-16