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|本期目录/Table of Contents|

白黎芦醇调节SIRT1表达研究的新进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第2期
页码:
231-233
栏目:
综述
出版日期:
2015-11-25

文章信息/Info

Title:
New findings of resveratrol in regulating expression of SIRT1
作者:
李 珊; 吕安林; 邱翠婷; 马晓磊; 姜晓宇; 郭 显
(第四军医大学西京医院心血管内科，陕西 西安 710032)
Author(s):
LI Shan;  L? An-lin;  QIU Cui-ting;  MA Xiao-lei;  JIANG Xiao-yu;  GUO Xian
(Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
白黎芦醇; 烟酰胺腺嘌呤二核苷酸; SIRT1
Keywords:
resveratrol;  NAD+;  SIRT1
分类号:
R285.6
DOI:
-
文献标识码:
A
摘要:
SIRT1是依赖烟酰胺腺嘌呤二核苷酸(NAD+)的脱乙酰基酶，在低等动物中延长寿命，预防与年龄相关的疾病，包括代谢紊乱。激活SIRT1能增强线粒体的功能、氧化代谢和抵消肥胖。白黎芦醇是非黄酮类多酚类，属于对苯代乙烯组，是一些植物为了应对伤害和真菌攻击自然产生的。因此，白黎芦醇激活SIRT1对与年龄相关的疾病和生理代谢有重要的意义。
Abstract:
SIRT1 is an NAD+-dependent deacetylase that extends lifespan in lower organisms and prevents many age-related diseases including metabolic disorders. Activated SIRT1 enhances mitochondrial functions and oxidative metabolism and counteracts obesity. Resveratrol is a non-flavonoid polyphenol that belongs to the group of stilbenes and is produced naturally in several plants in response to injury or fungal attack. Therefore, activation of SIRT1 by resveratrol is beneficial for prevention of many age-related diseases and regulation of physiological metabolism.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-04-23.
作者简介：李珊，硕士生 Email：775899751@qq.com
更新日期/Last Update: 2016-04-25