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|本期目录/Table of Contents|

微血管功能在代谢综合征发生机制中的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第2期
页码:
234-236,240
栏目:
综述
出版日期:
2015-11-25

文章信息/Info

Title:
Research progress of microvascular functions in mechanism of metabolic syndrome
作者:
何金孝1; 王炜中2; 张海锋2; 孙 新1
（第四军医大学：1.西京医院儿科，2.基础部教学实验中心，陕西 西安 710032）
Author(s):
HE Jin-xiao1;  WANG Wei-zhong2;  ZHANG Hai-feng2;  SUN Xin1
(1.Department of Pediatrics, Xijing Hospital, 2.Department of Preclinical Medical Teaching Experiment Center, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
微血管功能障碍; 代谢综合征; 胰岛素抵抗; 高血压; 肥胖
Keywords:
microvascular dysfunction;  metabolic syndrome;  insulin resistance;  hypertension;  obesity
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
随着现代生活水平的不断提高，肥胖、心血管疾病、糖尿病等疾病的发病率逐年增加，构成重大的公共卫生挑战。大量临床资料、实验研究证实，微血管功能障碍不仅与肥胖相关的靶器官损伤的发生发展密切相关，而且是心血管事件（如高血压和胰岛素抵抗）的高危风险因素。现在本文将综述微血管功能障碍与肥胖、高血压与胰岛素抵抗（IR）之间的相互关联及其作用机制。
Abstract:
The increasing prevalence of chronic diseases such as obesity, cardiovascular disease and diabetes has been a severe public health challenge worldwide. A large number of clinical and experimental studies have confirmed that microvascular dysfunction is not only closely associated with obesity-related target-organ damage but is also a high risk factor for cardiovascular events such as hypertension and insulin resistance. In this review we will focus on the correlation between microvascular dysfunction and obesity, hypertension and insulin resistance, as well as its underlying mechanisms.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-03-29.
基金项目：国家自然科学基金项目资助（81270330，30700345，31371151，31271219）；陕西省科技厅国际合作项目资助（2013KW30-02）
通讯作者：孙新，副教授，主要从事肺动脉高压研究 Email:sunxin6@fmmu.edu.cn
共同通讯作者：张海锋，副教授，主要从事心血管胰岛素抵抗研究 Email:hfzhang@fmmu.edu.cn
作者简介：何金孝，硕士生 Email:hejx_2013@1
更新日期/Last Update: 2016-04-25