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|本期目录/Table of Contents|

脂肪因子CTRP3的认识及研究现状

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第3期
页码:
341-343,361
栏目:
综述
出版日期:
2016-01-05

文章信息/Info

Title:
Mini-review for adipokine CTRP3
作者:
赵莎莎; 高 超; 陶 凌
（第四军医大学西京医院心血管内科，陕西 西安 710032）
Author(s):
ZHAO Sha-sha;  GAO Chao;  TAO Ling
(Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
C1q/肿瘤坏死因子相关蛋白3; 脂肪因子; 代谢调控; 抗炎; 心肌保护
Keywords:
CTRP3;  adipokines;  metabolic regulation;  anti-inflammatory;  myocardial preservation
分类号:
R392.12
DOI:
-
文献标识码:
A
摘要:
CTRP3是C1q肿瘤坏死因子相关蛋白家族中的一员，是新发现的脂肪因子。研究发现CTRP3在抗炎、代谢调控及减轻缺血损伤等方面发挥重要作用。本文就CTRP3的分子结构、表达、含量以及生物功能做一综述。
Abstract:
CTRP3 is a newly identified adipokine, which is a member of the C1q/TNF-related protein family. Research has shown that CTRP3 has anti-inflammatory, anti-ischemic and metabolic regulation properties. In this review we focused on the structure, tissue expression, content and biological functions of CTRP3.

参考文献/References

[1]Schaffler A,Buechler C.CTRP family:linking immunity to metabolism[J].Trends Endocrinol Metab,2012,23(4):194-204.
[2]Peterson JM,Wei Z,Wong GW.C1q/TNF-related protein-3(CTRP3),a novel adipokine that regulates hepatic glucose output[J].J Biol Chem,2010,285(51):39691-39701.
[3]Wong GW,Krawczyk SA,Kitidis-Mitrokostas C,et al.Molecular,biochemical and functional characterizations of C1q/TNF family members:adipose-tissue-selective expression patterns,regulation by PPAR-gamma agonist,cysteine-mediated oligomerizations,combinatorial associations and metabolic functions[J].Biochem J,2008,416(2):161-177.
[4]Kopp A,Bala M,Buechler C,et al.C1q/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue[J].Endocrinology,2010,151(11):5267-5278.
[5]Choi KM,Hwang SY,Hong HC,et al.Implications of C1q/TNF-related protein-3(CTRP-3)and progranulin in patients with acute coronary syndrome and stable angina pectoris[J].Cardiovasc Diabetol,2014,13:14.
[6]Yoo HJ,Hwang SY,Hong HC,et al.Implication of progranulin and C1q/TNF-related protein-3(CTRP3)on inflammation and atherosclerosis in subjects with or without metabolic syndrome[J].PloS one,2013,8(2):e55744.
[7]Compton SA,Cheatham B.CTRP-3:blocking a toll booth to obesity-related inflammation[J].Endocrinology,2010,151(11):5095-5097.
[8]Kopp A,Bala M,Weigert J,et al.Effects of the new adiponectin paralogous protein CTRP-3 and of LPS on cytokine release from monocytes of patients with type 2 diabetes mellitus[J].Cytokine,2010,49(1):51-57.
[9]Hofmann C,Chen N,Obermeier F,et al.C1q/TNF-related protein-3(CTRP-3)is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts[J].Inflamm Bowel Dis,2011,17(12):2462-2471.
[10]Choi KM,Hwang SY,Hong HC,et al.C1q/TNF-related protein-3(CTRP-3)and pigment epithelium-derived factor(PEDF)concentrations in patients with type 2 diabetes and metabolic syndrome[J].Diabetes,2012,61(11):2932-2936.
[11]Yi W,Sun Y,Yuan Y,et al.C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart[J].Circulation,2012,125(25):3159-3169.
[12]Maeda T,Wakisaka S.CTRP3/cartducin is induced by transforming growth factor-beta1 and promotes vascular smooth muscle cell proliferation[J].Cell Biol Int,2010,34(3):261-266.

备注/Memo

备注/Memo:
收稿日期: 2015-02-02.
基金项目：陕西省重点科技创新团队计划项目基金资助(2014KCT-19)；国家自然科学基金面上项目基金 资助(81470478)；国家自然科学基金青年项目基金资助(81225001)
通讯作者：陶凌，主任医师，主要从事糖尿病心肌损伤研究 Email：lingtao2006@gmail.com
作者简介：赵莎莎，硕士生 Email：zhaoss0407@qq.com
更新日期/Last Update: 2016-01-07