我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

钙化性主动脉瓣狭窄病理机制及治疗进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第3期
页码:
366-369
栏目:
综述
出版日期:
2016-01-05

文章信息/Info

Title:
Pathogenesis and treatment of calcific aortic valve stenosis
作者:
叶 挺1; 宗刚军2
(1.安徽医科大学无锡临床学院心内科，江苏 无锡 214044；
2.中国人民解放军第101医院心血管内科，江苏 无锡 210044）
Author(s):
YE Ting1;  ZONG Gang-jun2
(1.Department of Cardiology, Wuxi Clinical Hospital, Anhui Medical University, Wuxi 214044, Jiang Su,China；
2.Department of Cardiology, PLA 101 Hospital, Wuxi 210044, Jiangsu, China)
关键词:
主动脉瓣狭窄; 心脏瓣膜病; 钙化性主动脉瓣膜病; 发病机理与治疗
Keywords:
aortic valve stenosis;  heart valve disease;  calcific aortic valve disease;  pathogenesis and treatment
分类号:
R542.5
DOI:
-
文献标识码:
A
摘要:
主动脉瓣狭窄是临床上比较常见的心脏瓣膜病，其主要的病因是主动脉瓣膜钙化。随着人口老龄化的加剧，钙化性主动脉瓣膜病的发病率也不断的增加，因此，过去20多年中，钙化性主动脉瓣膜狭窄一直被认为是一种退行性病变，然而随着近年的研究进展，大量的证据表明，钙化性主动脉瓣膜病是一个活跃的病理过程，其与动脉粥样硬化有相同的风险因素和病理生理特点。本文主要对近年来钙化性主动脉瓣膜病发病机制及治疗进展的研究做一综述。
Abstract:
Aortic stenosis is clinically more common valvular heart disease, and the main cause is aortic valve calcification. With the increase in aging of the population, calcific aortic valve disease incidence also increased continuously. Therefore, during the past 20 years, calcific aortic valve stenosis has been considered as a degenerative disease, but with research progress in recent years, a large amount of evidence indicates that calcific aortic valve disease is an active disease process similar to that of atherosclerosis with the same risk factors and pathophysiological features. This paper summarizes the main research on the progression of the pathogenesis of calcific aortic valve disease and treatment in recent years.

参考文献/References

[1]Maganti K,Rigolin VH,Sarano ME,et al.Valvular heart disease:diagnosis and management[J].Mayo Clin Proc,2010,85(5):483-500.
[2]Supino PG,Borer JS,Preibisz J,et al.The epidemiology of valvular heart disease: a growing public health problem[J].Heart Fail Clin,2006,2(4):379-393.
[3]Rajamannan NM,Evans FJ,Aikawa E,et al.Calcifi aortic valve disease:not simply a degenerative process:a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group.Executive summary:calcifi aortic valve disease-2011 update[J].Circulation,2011,124(16):1783-1791.
[4]Tobin JR Jr,Rahimtoola SH,Blundell PE,et al.Percentage of left ventricular stroke work loss. A simple hemodynamic concept for estimation of severity in valvular aortic stenosis[J].Circulation,1967,35(5):868-879.
[5]Nassimiha D,Aronow WS,Ahn C,et al.Rate of progression of valvular aortic stenosis in patients>or=60 years of age[J].Am J Cardiol,2001,87(6):807-809,A9.
[6]Vahanian A,Baumgartner H,Bax J,et al.Task Force on the Management of Valvular Hearth Disease of the European Society of Cardiology;ESC Committee for Practice Guidelines.Guidelines on the management of valvular heart disease:The Task Force on the Management of valvular heart disease of the European Society of Cardiology[J].Eur Heart J,2007,28(2):230-268.
[7]Vahanian A,Alfiri O,Andreotti F,et al.Guidelines on the management of valvular heart disease(version 2012):the Joint Task Force on the management of valvular heart disease of the European Society of Cardiology(ESC)and the European Association for Cardio-Thoracic Surgery(EACTS)[J].Eur J Cardiothorac Surg,2012,42(4):S1-S44.
[8]Liu AC,Joag VR,Gotlieb AI.The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology[J].Am J Pathol,2007,171(5):1407-1418.
[9]Otto CM,Kuusisto J,Reichenbach DD,et al.Characterization of the early lesion of‘degenerative’valvular aortic stenosis.Histological and immunohistochemical studies[J].Circulation,1994,90(2):844-853.
[10]Stewart BF,Siscovick D,Lind BK,et al.Clinical factors associated with calcify aortic valve disease.Cardiovascular Health Study[J].J Am Coll Cardiol, 1997,29(3):630-634.
[11]Lindroos M,Kupari M,Heikkilá J,et al.Prevalence of aortic valve abnormalities in the elderly:an echocardiographic study of a random population sample[J].J Am Coll Cardiol,1993,21(5):1220-1225.
[12]Balachandran K,Sucosky P,Jo H,et al.Elevated cyclic stretch induces aortic valve calcifiation in a bone morphogenic protein-dependent manner[J].Am J Pathol,2010,177(1):49-57.
[13]Xing Y,Warnock JN,He Z,et al.Cyclic pressure affects the biological properties of porcine aortic valve leaflts in a magnitude and frequency dependent manner[J].Ann Biomed Eng,2004,32(11):1461-1470.
[14]Beppu S,Suzuki S,Matsuda H,et al.Rapidity of progression of aortic stenosis in patients with congenital bicuspid aortic valves[J].Am J Cardiol,1993,71(4): 322-327.
[15]Olsson M,Thyberg J,Nilsson J.Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves[J].Arterioscler Thromb Vasc Biol,1999,19(5):1218-1222.
[16]Kaden JJ,Dempfl CE,Grobholz R,et al.Interleukin-1 β promotes matrix metalloproteinase expression and cell proliferation in calcifi aortic valve stenosis[J].Atherosclerosis,2003,170(2):205-211.
[17]Helske S,Lindstedt KA,Laine M,et al.Induction of local angiotensin II-producing systems in stenotic aortic valves[J].J Am Coll Cardiol,2004,44(9):1859-1866.
[18]Yamamoto K,Yamamoto H,Yoshida K,et al.Prognostic factors for progression of early- and late-stage calcifi aortic valve disease in Japanese: the Japanese Aortic Stenosis Study (JASS) retrospective analysis[J].Hypertens Res, 2010,33(3):269-274.
[19]Mohler ER 3rd,Gannon F,Reynolds C,et al.Bone formation and inflmmation in cardiac valves[J].Circulation,2001,103(11):1522-1528.
[20]Linhartová K,Veselka J,Sterbáková G,et al.Parathyroid hormone and vitamin D levels are independently associated with calcify aortic stenosis[J].Circ J,2008,72(2):245-250.
[21]Rosenhek R,Rader F,Loho N,et al.Statins but not angiotensin-converting enzyme inhibitors delay progression of aortic stenosis[J].Circulation,2004,110(10):1291-1295.
[22]Rosseb? AB,Pedersen TR,Boman K,et al.SEAS Investigators.Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis[J].N Engl J Med,2008,359(13):1343-1356.
[23]Helske S,Otto CM.Lipid lowering in aortic stenosis:still some light at the end of the tunnel?[J].Circulation,2009,119(20):2653-2655.
[24]Miller JD,Weiss RM,Serrano KM,et al.Lowering plasma cholesterol levels halts progression of aortic valve disease in mice[J].Circulation,2009,119(20):2693-2701.
[25]Ngo DT,Stafford I,Sverdlov AL,et al.Ramipril retards development of aortic valve stenosis in a rabbit model:mechanistic considerations[J].Br J Pharmacol,2011,162(3):722-732.
[26]Marian AJ,Nambi V.Biomarkers of cardiac disease[J].Expert Rev Mol Diagn,2004,4(6):805-820.
[27]Martín-Rojas T,Gil-Dones F,Lopez-Almodovar LF,et al.Proteomic profie of human aortic stenosis: insights into the degenerative process[J].J Proteome Res,2012,11(3):1537-1550.

备注/Memo

备注/Memo:
收稿日期：2015-03-10.
基金项目：国家自然科学基金项目资助（81371657）
通讯作者：宗刚军，副主任医师，主要从事高血压病基础与临床研究 Email：zonggj@163.com
作者简介：叶挺，硕士生 Email：1318521707@qq.com
更新日期/Last Update: 2016-01-07