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|本期目录/Table of Contents|

类风湿关节炎并发心血管损害的临床特点与相关因素

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第4期
页码:
447-449,463
栏目:
临床研究
出版日期:
2016-04-01

文章信息/Info

Title:
Clinical features and related factors of rheumatoid arthritis complicated with cardiovascular damage
作者:
吕婷婷; 李 羽; 殷振杰; 王鑫博; 刘 洁; 张 岩
(第四军医大学唐都医院风湿免疫科，陕西 西安 710038)
Author(s):
L? Ting-ting;  LI Yu;  YIN Zhen-Jie;  WANG Xin-Bo;  LIU Jie;  ZHANG Yan
(Department of Rheumatology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shaanxi, China)
关键词:
关节炎; 类风湿; 心血管损害; 临床特点
Keywords:
rheumatoid;  arthritis;  cardiovascular disease;  clinical features
分类号:
R392.6
DOI:
-
文献标识码:
A
摘要:
目的 分析类风湿关节炎(rheumatoid arthritis，RA)患者并发心血管损害（CVD）的临床特点及相关因素。方法 回顾性分析RA患者临床资料122例，分为并发CVD的RA (并发CVD组)62例和未并发CVD的RA (单纯RA组)60例为对照组，进行单因素分析和多因素分析，多因素分析采用Logistic回归。结果 并发CVD组中患者发病年龄较小、病程较长，两组差异有统计学意义（P<0.05），在性别比例、年龄、体质量指数（BMI）差异无统计学意义；并发CVD组中常见损害依次为高血压病、高脂血症和冠心病；心脏超声异常以瓣膜返流(61%)最多见；Logistic回归分析提示28个关节疾病活动度（DAS-28）评分、C反应蛋白（CRP）、总胆固醇（TC）和D二聚体水平升高与并发CVD密切相关。结论 CVD为RA患者常见的关节外表现,且表现多样。DAS-28 评分、CRP、TC和D二聚体水平升高与RA并发CVD密切相关。
Abstract:
AIM To investigate the clinical features and related factors of patients with rheumatoid arthritis (RA) and cardiovascular disease (CVD). METHODSClinical data of 112 patients hospitalized in Tangdu Hospital from January 2012-December 2014 were collected. Retrospective analysis of the data and relevant logistic regression analysis were performed. RESULTSCompared with those in RA patients without CVD, age of onset was younger and course of the disease was longer (P<0.05). No significant difference was observed in gender ratio, age and body mass index (BMI). The common damage found in RA-CVD group was hypertension, hyperlipidemia and coronary heart disease. The most common cardiac abnormality detected by ultrasound was valvular regurgitation (60.8%). Logistic regression analysis showed that DAS-28 score, CRP, elevated TC and D-dimer levels were closely associated with RA-CVD. CONCLUSIONCardiovascular damage in RA patients is common and also diverse joint manifestations. DAS28 score, elevated CRP, TC and D-dimer are closely related to RA-CVD.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-08-28.
基金项目：陕西省社发攻关基金项目资助（2012K16-12-04）
通讯作者：张岩，副主任医师，主要从事自身免疫病发病机制的研究 Email：zyhphc@fmmu.edu.cn
作者简介：吕婷婷，主治医师，硕士 Email：tinglvnmg@163.com
更新日期/Last Update: 2016-04-01