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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2016年第4期

页码:

457-459

栏目:

临床研究

出版日期:

2016-04-01

文章信息/Info

Title:

Correlation of hyperuricemia and metabolic syndrome components

作者:

赵卫云¹; 张慧敏²; 李 辉¹; 张 静¹; 刘凤莲³; 高 颖¹

(1.新疆医科大学第一附属医院干部病房内二科，新疆 乌鲁木齐 830054；
2.九江学院附属医院肿瘤内科，江西 九江 332000；
3.湖北省老河口市第一医院检验科，湖北 老河口 441800)

Author(s):

ZHAO Wei-yun¹;  ZHANG Hui-min²;  LI Hui¹;  ZHANG Jing¹;  LIU Feng-lian³;  GAO Ying¹

(1.Department of Internal Medicine, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang, China；
2.Department of Medical Oncology, Affiliated Hospital, Jiujiang Medical University, Jiujiang 332000, Jiangxi, China；
3.Department of Laboratory Medicine, First Hospital of Laohekou, Laohekou 441800, Hubei, China)

关键词:

高尿酸血症; 代谢综合征

Keywords:

hyperuricemia;  metabolic syndrome

分类号:

R589

DOI:

-

文献标识码:

A

摘要:

目的 分析高尿酸血症与代谢综合征及其组分的相关性。方法 选择2014年新疆医科大学第一附属医院体检中心符合入选标准的2 778名体检者，根据高尿酸血症的诊断标准分为高尿酸血症组（593例)及正常尿酸组(2 185例)，对收集的临床及生化指标进行统计分析。结果 高尿酸血症相关因素的单因素分析显示，性别、体质量指数（BMI）、收缩压（SBP）、舒张压（DBP）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖（FPG）及是否并发代谢综合征（MS）在高尿酸血症组与正常尿酸组间分布差异有统计学意义（P<0.01）；经多因素Logistic回归分析，BMI（超重/肥胖）、高血压病（SBP、DBP）、高TG、低HDL-C及MS是高尿酸血症发生的相关因素（P<0.01）；Pearson相关性分析示高尿酸血症与HDL-C呈负相关（r=-0.195,P<0.001）。结论 高尿酸血症与代谢综合征组分密切相关。

Abstract:

AIM To analyze the correlation of hyperuricemia (HUA) and metabolic syndrome (MetS) components. METHODSA total of 2778 subjects who underwent physical examination in the First Affiliated Hospital of Xinjiang Medical University in 2014 were divided into HUA group (593 cases) and normal uricemia group (2185 cases) according to the diagnostic criteria of hyperuricemia. Clinical data and biochemical indices were collected and statistical analysis was conducted. RESULTSUnivariate analysis of hyperuricemia showed that the distribution of gender, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), high-density lipoprotein (HDL-C), fasting plasma glucose (FPG) and MetS in HUA group was significantly different from that in normal uricemia group (P<0.01). Logistic regression indicated that overweight/obesity, hypertension, higher levels of TG, lower level of HDL-C and MetS were factors correlative of HUA (P<0.01). CONCLUSIONHyperuricemia is closely related to components of MetS. Pearson correlation suggests that hyperuricemia was negatively correlated with high-density lipoprotein (HDL-C) (r=-0.195, P<0.01).

参考文献/References

[1]中华医学会心血管病学分会,中国老年学学会心脑血管病专业委员会.心血管疾病防治指南和共识[M].北京:人民卫生出版社, 2011:100.
[2]王礼文，陈 健，冯学山，等.社区老年男性人群代谢综合征与高尿酸血症相关性分析[J].国际医药卫生导报,2013,19(16):2512-2514.
[3]Wannam SG.Serum uric acid and risk of coronary heart disease[J].Curr Pharm Des,2005,11(1):4125-4132.
[4]中华医学会糖尿病分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议[J].中华糖尿病杂志,2004,12(3):156-158.
[5]Einollahi B,Einollahi H,Rostami Z,et al.Elderly renal transplant recipients and renal dysfunction: a risk factor for hyperuricemia[J].Exp Clin Transplant,2011,9(6):376-380.
[6]刘湘源,肖玉兰.老年人高尿酸血症调查及影响因素分析[J].中华风湿病学杂志,2005,9(5):280-283.
[7]Yang T,Chu CH,Bai CH,et al.Uric acid level as a risk marker for metabolic syndrome:a Chinese cohort study[J].Atherosclerosis,2012,220(2):525-531.
[8]Yu J,Han J,Mao J,et al.Association between serum uric acid level and the severity of coronary artery disease in patients with obstructivecoronary artery disease[J].Chin Med J (Engl),2014,127(6):1039-1045.
[9]卢光娅.高尿酸血症与代谢综合征的相互影响及研究进展[J].重庆医学,2011, 40(15):1542-1543.
[10]Ioachimescu AG,Brennan DM,Hoar BM,et al.Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study[J].Arthritis Rheumv,2008,58(2):623-630.
[11]邵春海，刘景芳，苏健光,等.尿酸血症与代谢综合征各组分间的关系及营养治疗[J].上海医药,2013,34(5):11-13.
[12]梁 凯，曲 勇，邓 楠，等.无症状性高尿酸血症与代谢综合征及其组分相关性的研究[J].中国糖尿病杂志,2013,21(5):388-391.
[13]Zhang Q,Zhang C,Song X,et al.A longitudinal cohort based association study between uric acid level and metabolic syndrome in Chinese Han urban male population[J].BMC Public Heahh,2012,12:419.
[14]Lee HJ,Park HT,Cho GJ,et al.Relationship between uric acid and metabolic syndrome according to menopausal status[J].Gynecol Endocrinol,2011,27(6):406-411.
[15]Zhu WH,Fang LZ,Chen LY,et al.Follow-up study of programmed intervention of hyperurieemia in the prevention and treatment of cardiovascular morbid change[J].Zhonghua Yi Xue Za Zhi,2010,90(10):662-666.

备注/Memo

备注/Memo:

收稿日期：2015-05-24.
基金项目：新疆维吾尔自治区科技计划项目资助（201554141）
通讯作者：高颖，主任医师，主要从事脂源性激素代谢研究 Email：sunflowergaoying@163.com
作者简介：赵卫云，硕士生 Email：873048699@qq.com

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更新日期/Last Update: 2016-04-01