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|本期目录/Table of Contents|

丹红注射液对心肺复苏患者早期凝血功能的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第4期
页码:
468-470
栏目:
临床研究
出版日期:
2016-04-01

文章信息/Info

Title:
Protective effects of danhong injection on early coagulation after cardiopulmonary resuscitation
作者:
王 瑞1; 樊 颖2; 钱 露3; 肖林萍1; 王敏玲1; 张卫国1 ; 贺东风1
(1.解放军451医院门诊部，陕西 西安 710054；
2.空军装备研究院门诊部，北京 100085；
3.西安市第四人民医院门诊部，陕西 西安 710061）
Author(s):
WANG Rui1;  FAN Ying2;  QIAN Lu3;  XIAO Lin-ping1;  WANG Min-ling1;  ZHANG Wei-guo1;  HE Dong-feng1
(1.Outpatient Department, PLA 451 Hospital, Xi’an 710054, Shaanxi, China；
2.Equipment Academy of Air Force, Beijing 100085, China；
3.Outpatient Department, Xi’an Fourth People’s Hospital, Xi’an 710061, Shaanxi, China)
关键词:
心肺复苏; 丹红注射液; 凝血功能
Keywords:
cardiopulmonary resuscitation;  danhong injection;  coagulation
分类号:
R654.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨丹红注射液对心肺复苏（CPR）患者早期凝血功能的影响。方法 72例CPR患者随机分为试药组（n=37）、复苏组（n=35），试药组再灌注后在常规复苏基础上予丹红注射液，观察2组凝血功能指标及APACHEⅡ评分的变化。结果 试药组治疗后活化部分凝血活酶时间（APTT）、血浆凝血酶原时间（PT）、血浆凝血酶时间（TT）、纤维蛋白原（FIB）、血小板平均体积（MPV）、APACHEⅡ评分与较试药组治疗前及与复苏组治疗后比较降低（P<0.05），血小板计数（PLT）增高（P<0.05）。结论 丹红注射液能有效减少心肺复苏再灌注凝血异常的发生，改善预后。
Abstract:
AIM To investigate the protective effects of danhong injection on coagulation after cardiopulmonary resuscitation (CPR). METHODSAfter cardiopulmonary resuscitation, 72 patients were randomly divided into danhong injection treatment group (n=37) and resuscitation group (n=35), and 30 healthy subjects served as control group. Routine treatment was adopted for all patients. In the treatment group, danhong injection was added in addition to the routine treatment. Coagulation was examined in all three groups and APACHE II scores were evaluated in the treatment group and resuscitation group. RESULTSCoagulopathy was demonstrated in both treatment group and resuscitation group. After treatment, prothrombin time (PT), thrombin time (TT), fibrin (FIB), mean platelet volume (MPV) and APACHE II score were all significantly lower, and platelet (PLT) count was higher in treatment group compared with PLT count in treatment group before treatment and those in resuscitation group after treatment (P<0.05). CONCLUSIONDanhong injection can effectively reduce coagulopathy and improve clinical outcomes.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期: 2015-11-03.
作者简介：王瑞，主任医师，硕士 Email：ruitao_1991@aliyun.com
更新日期/Last Update: 2016-04-01