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|本期目录/Table of Contents|

整合素与房颤的心肌纤维化

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第5期
页码:
605-607
栏目:
综述
出版日期:
2016-04-25

文章信息/Info

Title:
Integrin and myocardial fibrosis of atrial fibrillation
作者:
赵 越 综述; 张丽丽 审校
（哈尔滨医科大学附属第四医院心内科，黑龙江 哈尔滨 150000）
Author(s):
ZHAO Yue;  ZHANG Li-li
(Department of Cardiovascular Medicine, Fourth Affiliated Hospital, Harbin Medical University, Harbin 150000, Heilongjiang, China)
关键词:
心房颤动; 心肌纤维化; 炎症; 整合素
Keywords:
atrial fibrillation;  myocardial fibrosis;  inflammation;  integrin
分类号:
R541.7
DOI:
-
文献标识码:
A
摘要:
心房纤维性颤动（AF）是最常见的心律失常之一，它是由心房主导环折返引起许多小折返环导致的房律紊乱。而炎症已在AF的发病中发挥作用。黏附分子包括整合素作为早期炎性反应的调控介质和信号介导分子可激活信号转导通路，包括丝裂原活化蛋白激酶和局部黏着斑激酶，而使胶原细胞分泌胶原增多，提示AF心肌纤维化的发生可能与胶原的增加有关。研究整合素与AF心肌纤维化的关系有利于减少心肌纤维化的发生率，从而可以降低AF的发生。
Abstract:
Atrial fibrillation (AF) is a most common type of tachycardia caused by atrial re-entrant circuits and small re-entrant circuits. Inflammation plays a role in the pathophysiology of AF and adhesion molecules are an early inflammatory response modulator (including integrin), which serves as the signal transduction factor and activates signal transduction pathways, including mitogen-activated protein kinases and focal adhesion kinase. Collagen cells will then secrete more collagen. Atrial myocardial fibrosis may be associated with increasing collagen. Studies of the relationship of integrin and atrial myocardial fibrosis will show the mechanism of myocardial fibrosis and thus reduce the incidence of AF.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-03-05.
通讯作者：张丽丽,主任医师，主要从事心律失常发病机制研究及临床治疗 Email：drzhanglili@163.com
作者简介：赵越，硕士生 Email：390877575@qq.com
更新日期/Last Update: 2016-04-13