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|本期目录/Table of Contents|

糖尿病性心肌病与内质网应激的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第5期
页码:
611-615
栏目:
综述
出版日期:
2016-04-25

文章信息/Info

Title:
Relationship between endoplasmic reticulum stress and diabetic cardiomyopathy
作者:
毛 予1; 王 可1; 杨丽芳2
(第四军医大学：1.学员1旅；
2.第一附属医院麻醉科，陕西 西安 710032)
Author(s):
MAO Yu1;  WANG Ke1;  YANG Li-fang2
(1.First Cadet Brigade；
2.Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
内质网应激; 糖尿病性心肌病; 自噬; 凋亡
Keywords:
endoplasmic reticulum stress;  diabetic cardiomyopathy;  autophagy;  apoptosis
分类号:
R587.2
DOI:
-
文献标识码:
A
摘要:
内质网应激（ERS）在维持内质网稳态的适应性应答中发挥着关键作用。近年来关于糖尿病(DM)的研究越来越多，研究显示在糖尿病性心肌病(DCM)早期，高血糖症、过多的游离脂肪酸以及炎症等多种致病因素均可导致ERS，ERS在DM的发展及其并发症形成中发挥着极为重要的作用。本文对ERS的经典通路、内质网功能紊乱与细胞自噬、凋亡的联系以及由于内质网功能紊乱导致机体产生胰岛素抵抗和DCM的过程进行了综述。
Abstract:
Endoplasmic reticulum (ER) stress plays an important role in the maintenance of ER homeostasis. Recently, more research has shown that a unique role has been speculated for ER stress in the pathogenesis of diabetes mellitus (DM) and its complications. Recent studies have also shown that ER stress is an early event associated with diabetic cardiomyopathy and may be triggered by hyperglycemia, free fatty acids (FFAs) and inflammation. In this mini-review we attempted to discuss the activation mechanism for ER stress in response to these triggers en route to disrupted ER functions and cellular autophagy or apoptosis, which ultimately induces insulin resistance and development of diabetic cardiomyopathy.

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备注/Memo

备注/Memo:
收稿日期：2014-11-30.
通讯作者：杨丽芳，主治医师，主要从事心肌保护研究 Email：yanglf@fmmu.edu.cn
作者简介：毛予，本科生 Email：1107128975@qq.com
更新日期/Last Update: 2016-04-13