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|本期目录/Table of Contents|

Alarin对心血管功能的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第6期
页码:
666-670
栏目:
基础研究
出版日期:
2016-07-05

文章信息/Info

Title:
Effect of alarin on cardiovascular physiological function
作者:
王凯兴; 高 丽; 崔 艳
(第四军医大学护理学院, 陕西 西安 710032)
Author(s):
WANG Kai-xing;  GAO Li;  CUI Yan
(Nursing School, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
Alarin; 血管活性肽; 心血管; 大鼠
Keywords:
alarin;  vascular active peptide;  cardiovascular system;  rat
分类号:
R331.3
DOI:
-
文献标识码:
A
摘要:
目的 探讨促生长激素神经肽家族新成员Alarin对心血管系统生理功能是否具有调节作用，并为进一步认识Galanin家族分子的生物学作用提供更多的实验依据。方法 选用3种不同来源的Alarin（1-25,3-25,6-25）分别来自Kofler实验室赠送的Alarin（1-25, 3-25），国内上海强耀生物技术公司合成的Alarin(1-25, 3-25)和第四军医大学基因所合成的Alarin（1-25，3-25，6-25），将实验大鼠随机分为2组：阳性对照组〔去甲肾上腺素(NE)组〕和实验组（Alarin组），通过整体动物实验测定血流动力学和离体心脏灌流实验测定血管张力，分别观察Alarin对实验大鼠心脏功能、血压、心率、血管张力等指标的影响。结果 在实验组中3种不同来源的Alarin（1-25,3-25,6-25）分别在不同剂量时对大鼠的收缩压、舒张压、心率以及左室收缩压、左室收缩压上升和下降最大速率等心脏功能指标均没有明显影响，且不同终浓度的Alarin对大鼠腹主动脉的张力也无明显影响。而在NE组中，等剂量NE可明显增加收缩压、舒张压、心率以及左室收缩压、左室收缩压上升和下降最大速率等等心脏功能指标，且对大鼠腹主动脉具有明显的收缩作用。结论 Alarin对大鼠心脏及大血管的基础生理功能没有调节作用。
Abstract:
AIM To explore whether alarin, a new member of the galanin family, elicits a regulation on the cardiovascular system and to provide experimental evidence for the understanding of the biological effect of galanin protein family. METHODSThree types of alarin (1-25, 3 -25, 6-25) were synthesized by Kofler Laboratory in Australia and two domestic companies. Animals were randomly divided into two groups including positive control group (norepinephrine, NE group) and experimental group (alarin group). The effects of alarin on cardiac function, blood pressure, heart rate, and vascular tension were determined through animal experiments in vivo and vascular reperfusion experiments in vitro, respectively. RESULTSDifferent doses of alarin elicited no significant effect on blood pressure, heart rate and vascular tension. Synthetic alarin (1-25, 3-25, 6-25) from three companies at different doses had no significant effect on cardiac function, and the final concentration of alarin at 1, 2, 5, 10 mol/L had no effect on the tension of abdominal artery. NE produced a significant increase in cardivascular function. CONCLUSIONThe present study demonstrates that alarin alone may have no functional regulation on the cardiovascular system.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-11-17.
基金项目：国家自然科学基金项目资助（31200875）；国家自然科学基金项目资助（81270402）
通讯作者：崔艳，副教授，主要从事心血管研究Email:cuiyan@fmmu.edu.cn
作者简介：王凯兴，本科生Email:505328718@qq.com
更新日期/Last Update: 2016-07-10