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|本期目录/Table of Contents|

PAI-1与AMI患者冠状动脉内血栓形成溶栓后及复通的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第6期
页码:
708-710
栏目:
临床研究
出版日期:
2016-07-05

文章信息/Info

Title:
Relationship between plasminogen activator inhibitor-1 and acute myocardial infarction in patients with coronary artery thrombosis after thrombolytic therapy
作者:
詹 莉; 关秀军; 邓 斌
（武汉市第八医院心血管内科，湖北 武汉 430010）
Author(s):
ZHAN Li;  GUAN Xiu-jun;  DENG Bin
(Department of Cardiology, The Eighth Hospital of Wuhan, Wuhan 430010, Hubei, China)
关键词:
纤溶酶激活物抑制剂-1; 心肌梗死; 急性; 冠状动脉; 血栓; 纤溶系统
Keywords:
plasminogen activator inhibitor-1;  acute myocardial infarction;  coronary artery;  thrombus;  fibrinolytic system
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 分析纤溶酶激活物抑制剂（PAI）-1与急性心肌梗死（AMI）患者冠状动脉内血栓形成溶栓后及再通间的关系。方法 采用Logistic线性回归分析法对我院2013年1月~2015年2月收治的AMI冠脉内血栓形成并符合溶栓治疗适应证的患者41例，设为溶栓组，进行静脉溶栓治疗；再选取40例体检健康的人群作为正常对照组，分别记录溶栓组溶栓前后及与对照组对照的血浆PAI-1的检测值差异；并对溶栓后2 h冠脉再通组与未通组患者血浆PAI-1水平进行比较。结果 溶栓组溶栓前与对照组相比，血浆PAI-1水平显著高于正常对照组，有统计学差异（P<0.05）。溶栓组溶栓后0.5 h、1 h时血浆PAI-1水平与溶栓前比较，有所上升但差异无统计学意义，1.5 h、2 h时血浆PAI-1水平与溶栓前比较，显著上升有统计学差异（P<0.05），溶栓后2 h冠脉再通组血浆PAI-1水平显著低于未通组（P<0.05），具有统计学意义。结论 心肌梗死溶栓后PAI-1的水平在2 h内逐渐下降，且与血管再通有关联。
Abstract:
AIM To plasminogen activator inhibitor-1; acute myocardial infarction; coronary artery; thrombus; fibrinolytic systemanalyze the relationship between plasminogen activating inhibitor 1 (PAI-1) and acute myocardial infarction (AMI) in patients with coronary artery thrombosis after thrombolytic therapy and explore its clinical significance. METHODSLogistic linear regression analysis was conducted in 41 AMI patients with coronary artery thrombosis who were treated with thrombolytic therapy and 40 healthy controls. Plasma PAI-1 levels were recorded before and after thrombolysis in AMI patients and compared with those in control group. RESULTSCompared with the control group, plasma PAI-1 levels in AMI patients were significantly higher than those in control group (P<0.05). In AMI patients, plasma PAI-1 levels 0.5 h and 1 h after thrombolysis were higher but with no statistical significance compared with those before thrombolysis, whereas plasma PAI-1 levels 1.5 h and 2 h after thrombolysis were significantly higher than before thrombolysis (P<0.05). Plasma PAI-1 levels in patients with coronary recanalization 2 h after thrombolysis were significantly lower than in patients without coronary recanalization (P<0.05). CONCLUSIONPlasma PAI-1 levels gradually decrease within 2 h after thrombolysis, which is related to coronary recanalization.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2016-08-04.
作者简介：詹莉，主治医师，硕士Email：he2230035@126.com
更新日期/Last Update: 2016-07-10