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|本期目录/Table of Contents|

循环microRNAs:潜在的心血管疾病生物学标志物

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第6期
页码:
714-718
栏目:
综述
出版日期:
2016-07-05

文章信息/Info

Title:
Circulating microRNAs: potential biomarkers for cardiovascular diseases
作者:
孙嘉星1; 2; 张聚磊1; 2; 李 嘉1
（第四军医大学：1.航空航天医学系，2.学员一旅，陕西 西安 710032）
Author(s):
SUN Jia-xing1; 2;  ZHANG Ju-lei1; 2;  LI Jia1
(1.School of Aerospace Medicine, 2.First Cadet Brigade, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
循环microRNAs; 生物学标志物; 心血管疾病
Keywords:
circulating microRNA;  biomarker;  cardiovascular disease
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
MicroRNAs(miRNAs)是一类长约21~25碱基对的内源性非编码小分子RNA，广泛参与细胞的增殖、生长、分化以及凋亡等病理生理过程。越来越多的研究表明，循环miRNAs的表达变化与心肌梗死、心功能衰竭、动脉粥样硬化以及高血压的发生发展密切相关，可望成为潜在的生物学标志物用于心血管疾病的早期诊断和治疗靶点。
Abstract:
MicroRNAs (miRNAs) are a class of small ( 21-25 nt), endogenous and noncoding RNAs. MiRNAs act as crucial regulators of a wide range of physiological and pathological processes including cell proliferation, growth, differentiation and apoptosis. Recent studies have revealed distinctive patterns of circulating miRNAs in myocardial infarction, heart failure, atherosclerotic disease and hypertension. These circulating miRNAs may therefore be used as potential diagnostic biomarkers and therapeutic targets of cardiovascular diseases.

参考文献/References

[1]Bartel DP.MicroRNAs:genomics, biogenesis, mechanism, and function[J].Cell,2004,116(2):281-297.
[2]Creemers EE,Tijsen AJ,Pinto YM.Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?[J].Circ Res,2012,110(3):483-495.
[3]Aravin AA,Lagos-Quintana M,Yalcin A,et al.The small RNA profile during Drosophila melanogaster development[J].Dev Cell,2003,5(2):337-350.
[4]Han J,Lee Y,Yeom KH,et al.The Drosha-DGCR8 complex in primary microRNA processing[J].Genes Dev,2004,18(24):3016-3027.
[5]Yi R,Qin Y,Macara IG,et al.Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs[J].Genes Dev,2003,17(24):3011-3016.
[6]Ketting RF.microRNA Biogenesis and Function :An overview[J]. Adv Exp Med Biol,2011,700:1-14.
[7]Friedman RC,Farh KK,Burge CB,et al.Most mammalian mRNAs are conserved targets of microRNAs[J].Genome Res,2009,19(1):92-105.
[8]Kamm RC,Smith AG.Nucleic acid concentrations in normal human plasma[J].Clin Chem,1972,18(6):519-522.
[9]Chen X,Ba Y,Ma L,et al.Characterization of microRNAs in serum:a novel class of biomarkers for diagnosis of cancer and other diseases[J].Cell Res,2008,18(10):997-1006.
[10]Kondkar AA,Abu-Amero KK.Utility of circulating microRNAs as clinical biomarkers for cardiovascular diseases[J].Biomed Res Int,2015,2015:821823.
[11]Pigati L,Yaddanapudi SC,Iyengar R,et al.Selective release of microRNA species from normal and malignant mammary epithelial cells[J].PLoS One,2010,5(10):e13515.
[12]Kuwabara Y,Ono K,Horie T,et al.Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage[J].Circ Cardiovasc Genet,2011,4(4):446-454.
[13]Adachi T,Nakanishi M,Otsuka Y,et al.Plasma microRNA 499 as a biomarker of acute myocardial infarction[J].Clin Chem,2010,56(7):1183-1185.
[14]Peng L,Chun-guang Q,Bei-fang L,et al.Clinical impact of circulating miR-133,miR-1291 and miR-663b in plasma of patients with acute myocardial infarction[J].Diagn Pathol,2014,9:89.
[15]Wang GK,Zhu JQ,Zhang JT,et al.Circulating microRNA:a novel potential biomarker for early diagnosis of acute myocardial infarction in humans[J].Eur Heart J,2010,31(6):659-666.
[16]Lv P,Zhou M,He J,et al.Circulating miR-208b and miR-34a are associated with left ventricular remodeling after acute myocardial infarction[J].Int J Mol Sci,2014,15(4):5774-5788.
[17]Xiao J,Shen B,Li J,et al.Serum microRNA-499 and microRNA-208a as biomarkers of acute myocardial infarction[J].Int J Clin Exp Med,2014,7(1):136-141.
[18]D'Alessandra Y,Devanna P,Limana F,et al.Circulating microRNAs are new and sensitive biomarkers of myocardial infarction[J].Eur Heart J,2010,31(22):2765-2773.
[19]Mizuno H,Nakamura A,Aoki Y,et al.Identification of muscle-specific microRNAs in serum of muscular dystrophy animal models: promising novel blood-based markers for muscular dystrophy[J].PLoS One,2011,6(3):e18388.
[20]Endo K,Naito Y,Ji X,et al.MicroRNA 210 as a biomarker for congestive heart failure[J].Biol Pharm Bull,2013,36(1):48-54.
[21]Fukushima Y,Nakanishi M,Nonogi H,et al.Assessment of plasma miRNAs in congestive heart failure[J].Circ J,2011,75(2):336-340.
[22]Zampetaki A,Kiechl S,Drozdov I,et al.Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes[J].Circ Res,2010,107(6):810-817.
[23]Fichtlscherer S,De Rosa S,Fox H,et al.Circulating microRNAs in patients with coronary artery disease[J].Circ Res,2010,107(5):677-684.
[24]Goren Y,Meiri E,Hogan C,et al.Relation of reduced expression of MiR-150 in platelets to atrial fibrillation in patients with chronic systolic heart failure[J].Am J Cardiol,2014,113(6):976-981.
[25]Marfella R,Di Filippo C,Potenza N,et al.Circulating microRNA changes in heart failure patients treated with cardiac resynchronization therapy:responders vs.non-responders[J].Eur J Heart Fail,2013,15(11):1277-1288.
[26]Adhikari N,Guan W,Capaldo B,et al.Identification of a new target of miR-16, Vacuolar Protein Sorting 4a[J].PLoS One,2014,9(7):e101509.
[27]Schulte C,Zeller T.microRNA-based diagnostics and therapy in cardiovascular disease-Summing up the facts[J].Cardiovasc Diagn Ther,2015,5(1):17-36.
[28]Ren J, Zhang J, Xu N, et al. Signature of circulating microRNAs as potential biomarkers in vulnerable coronary artery disease［J］. PLoS One, 2013, 8(12):e80738.
[29]D'Alessandra Y,Carena MC,Spazzafumo L,et al.Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina[J].PLoS One,2013,8(11):e80345.
[30]Li S,Zhu J,Zhang W,et al.Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection[J].Circulation,2011,124(2):175-184.
[31]Karolina DS,Tavintharan S,Armugam A,et al.Circulating miRNA profiles in patients with metabolic syndrome[J].J Clin Endocrinol Metab,2012,97(12):E2271-E2276.
[32]Dickinson BA,Semus HM,Montgomery RL,et al.Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure[J].Eur J Heart Fail,2013,15(6):650-659.
[33]Zhang T,Lv C,Li L,et al.Plasma miR-126 is a potential biomarker for early prediction of type 2 diabetes mellitus in susceptible individuals[J].Biomed Res Int,2013,2013:761617.
[34]Rong Y,Bao W,Shan Z,et al.Increased microRNA-146a levels in plasma of patients with newly diagnosed type 2 diabetes mellitus[J].PLoS One, 2013,8(9):e73272.
[35]Higuchi C,Nakatsuka A,Eguchi J,et al.Identification of circulating miR-101,miR-375 and miR-802 as biomarkers for type 2 diabetes[J].Metabolism,2015,64(4):489-497.
[36]Zhu H,Leung SW.Identification of microRNA biomarkers in type 2 diabetes:a meta-analysis of controlled profiling studies[J]. Diabetologia,2015,58(5):900-911.
[37]Parrizas M,Brugnara L,Esteban Y,et al.Circulating miR-192 and miR-193b are markers of prediabetes and are modulated by an exercise intervention[J].J Clin Endocrinol Metab,2015,100(3):E407-E415.
[38]Santovito D,De Nardis V,Marcantonio P,et al.Plasma exosome microRNA profiling unravels a new potential modulator of adiponectin pathway in diabetes: effect of glycemic control[J].J Clin Endocrinol Metab,2014,99(9):E1681-E1685.

备注/Memo

备注/Memo:
收稿日期: 2015-07-17.
基金项目：国家高技术研究发展计划项目资助（2014AA020542）， 国家自然科学基金项目资助（31371150），全军优秀青年基金项目资助（13QNP121）
通讯作者：李嘉，副教授，主要从事心血管疾病方面研究Email：jiali816@fmmu.edu.cn
作者简介：孙嘉星，本科生Email：sjxsjx001@163.com
更新日期/Last Update: 2016-07-10