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|本期目录/Table of Contents|

重度慢性心力衰竭患者血尿酸水平与预后的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第3期
页码:
304-306
栏目:
临床研究
出版日期:
2017-01-25

文章信息/Info

Title:
Relationship between uric acid and prognosis in patients with severe congestive heart failure
作者:
陆金帅; 李 楠; 薛克栋
新疆维吾尔自治区人民医院重症医学一科，新疆 乌鲁木齐 830001
Author(s):
LU Jin-shuai;  LI Nan;  XUE Ke-dong
Department of Intensive Care Unit, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang, China
关键词:
血尿酸; 心力衰竭; 慢性; 全因死亡
Keywords:
uric acid;  congestive heart failure;  all-cause mortality
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的 分析血清尿酸（SUA）水平与重度慢性收缩性心力衰竭（CHF）患者预后的关系。方法 收集2014年4月~2015年1月于我院住院纽约心脏病协会（NYHA）心功能Ⅳ级CHF患者189例，对其随访6个月，终点事件为全因死亡。分析入院SUA水平与CHF住院患者6个月内全因死亡的关系。结果 按随访结果将患者分为死亡组和存活组。死亡组入院SUA水平明显高于存活组〔(514±30) μmol/L vs.(432±32) μmol/L，P<0.01〕。Pearson分析显示N末端脑钠尿肽前体（NT-proBNP）与SUA具有正相关性(r=0.345，P<0.05)。多因素Logistic回归分析显示，SUA水平（OR=1.213，95%CI:1.081-3.621，P<0.05），NT-proBNP（OR=1.456，95%CI:1.113-5.432，P<0.01），糖尿病（OR=2.105，95%CI:1.221-4.553，P<0.05）是CHF患者6个月全因死亡事件发生的独立危险因素。结论 血清SUA水平与重度CHF预后有相关性。
Abstract:
AIM To investigate the association between serum uric acid (SUA) and prognosis in patients with severe congestive heart failure (CHF). METHODS One hundred and eighty-nine consecutive patients with severe CHF hospitalized from April 2014 to January 2015 were included and the incidence of all-cause mortality during 6 months was observed. Statistical analyses were performed using SPSS 17.0. RESULTS Compared with the control group, uric acid level was significantly increased in all-cause mortality group ［(514±30) vs.(432±32) μmol/L, P<0.01］. Pearson related analysis indicated that the uric acid level was positively related to NT-proBNP (r=0.345, P<0.05). Multiple logistic regression analysis found that uric acid levels (OR=1.213, 95%CI: 1.081-3.621, P<0.05), NT-proBNP (OR=1.456, 95%CI: 1.113-5.432, P<0.01) and diabetes (OR=2.105, 95%CI: 1.221-4.553, P<0.05) were the independent risk factors for all-cause mortality within 6 months in severe CHF patients. CONCLUSION SUA level is associated with the prognosis in patients with severe CHF.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2016-06-02.通讯作者：薛克栋，教授，主要从事心律失常研究 Email：xiayingxue123@yahoo.com 作者简介：陆金帅，硕士生 Email：343667899@qq.com
更新日期/Last Update: 2017-02-20