NSTE-ACS患者GRACE评分和NLR与冠状动脉病变的关系(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2017年第4期
- 页码:
- 416-419
- 栏目:
- 临床研究
- 出版日期:
- 2017-02-25
文章信息/Info
- Title:
- Correlation of GRACE risk score, neutrophil to lymphocyte ratio and coronary artery disease in patients with non-ST-segment elevation acute coronary syndrome
- Author(s):
- WU Qiu-xiang; RUAN Ai-bing; HU Bao-kui; ZHANG Bing-yu
- Department of Cardiology, Wuhu Second People’s Hospital, Wuhu 241000, Anhui, China
- 分类号:
- R541.4
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的 研究非ST段抬高型急性冠脉综合征(NSTE-ACS)患者全球急性冠状动脉事件注册（GRACE）危险评分、中性粒细胞/淋巴细胞比值（NLR）与冠状动脉病变程度的相关性。方法 回顾性分析228例在我院住院并行冠脉造影的NSTE-ACS患者。根据GRACE评分将患者分为低危组、中危组及高危组。采用Gensini积分量化冠脉病变程度，按Gensini积分三分位间距将患者分为轻度、中度及重度病变组。分析GRACE评分、NLR与是否与不同程度的冠状动脉病变相关。结果 ①GRACE危险分层中危组及高危组NLR及Gensini积分较低危组升高（P<0.01），3支及左主干病变发生率高于低危组（P<0.01）。冠脉重度病变组GRACE危险评分、NLR均高于轻度病变组（P<0.01）。②GRACE危险评分及NLR与Gensini积分呈正相关关系。GRACE危险评分联合NLR对重度冠脉病变有中等预测价值（ROC曲线下面积 0.725,95%CI 0.653~0.798，P<0.01）。结论 GRACE危险评分、NLR与NSTE-ACS患者冠状动脉病变有良好相关性，可作为严重冠状动脉病变早期预测因子。
- Abstract:
- AIM To investigate the correlation of global registry of acute coronary events (GRACE) score, neutrophil to lymphocyte ratio (NLR) and severity of coronary artery disease in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). METHODS Two hundred and twenty-eight NSTE-ACS patients with confirmed diagnosis by coronary angiography in our hospital were studied retrospectively. Another 44 patients with negative coronary angiography were selected as control group. According to GRACE risk score, NSTE-ACS group was divided into low risk group, moderate risk group and high risk group. Gensini score was utilized to definite the severity of coronary artery disease. Based on the tertiles of the Gensini score, NSTE-ACS group was divided into three groups: mild lesion group, moderate lesion group and severe lesion group. The association of GRACE risk score, NLR and different degrees of coronary artery disease was examined. RESULTS GRACE risk score, NLR and Gensini score in NSTE-ACS group were higher than those in control group (P<0.01). NLR and Gensini score of moderate group and high risk group were higher than those in low risk group (P<0.01). The incidence of three-vessel and left-main coronary artery disease in moderate group and high risk group were higher than that in low risk group (P<0.01). The GRACE risk score and NLR in severe lesion group were higher compared with those in mild lesion group (P<0.01). GRACE risk score and NLR score were positively correlated with Gensini score. GRACE risk score combined with NLR were of moderate value in predicting severe coronary artery disease (Area under ROC curve: 0.725,95%CI 0.653-0.798, P<0.01). CONCLUSION GRACE risk score and NLR have a good correlation with the degrees of coronary artery disease in non-ST-segment elevation acute coronary syndrome patients and they can be used as early predictors for serious coronary artery disease.
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备注/Memo
- 备注/Memo:
- 收稿日期：2016-09-01.通讯作者：阮爱兵，主任医师，主要从事冠心病介入治疗研究 Email：rab888@163.com 作者简介：吴秋香，主治医师，硕士 Email：2479043549@qq.com
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