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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2017年第4期

页码:

420-421,442

栏目:

临床研究

出版日期:

2017-02-25

文章信息/Info

Title:

An analysis of correlative factors of hypertension with newly diagnosed diabetic patients

作者:

刘 博¹; 张 勇¹; 刘富强¹; 徐 晶¹; 王军奎¹; 马爱群²

1.陕西省人民医院心内科，陕西 西安 710068；2.西安交通大学第一附属医院心内科，陕西 西安 710061

Author(s):

LIU Bo¹;  ZHANG Yong¹;  LIU Fu-qiang¹;  XU Jing¹;  WANG Jun-kui¹;  MA Ai-qun²

1.Department of Cardiology, Shaanxi Provincial People’s Hospital, Xi’an 710068, Shaanxi, China; 2.Department of Cardiology, First Affiliated Hospital, Medical College, Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China

关键词:

高血压; 原发性; 糖尿病; 血脂; 糖化血红蛋白

Keywords:

hypertension;  primary;  type 2 diabetes mellitus;  glycosylated hemoglobin;  plasma lipid profiles

分类号:

R544.1；R587.1

DOI:

-

文献标识码:

A

摘要:

目的 分析原发性高血压并发初发糖尿病的相关因素。方法 搜集2013年6月~2016年6月陕西省人民医院心内科收住入院诊断高血压病并发从未使用药物治疗的新诊断2型糖尿病患者468例作为并发糖尿病组。与同期入院诊断单纯原发性高血压患者468例作为对照组（非糖尿病组）比较分析。结果 并发糖尿病组与非糖尿病组比较，体质量指数〔(28.8±3.9) kg/m2 vs.(25.1±3.2) kg/m2，P<0.05〕、HbA1c〔(9.4±1.6)% vs.(6.0±0.4)%,P<0.05〕、总胆固醇（TC）〔(4.8±1.4) mmol/L vs.(3.2±0.8) mmol/L，P<0.05〕、三酰甘油(TG）〔(2.2±1.3) mmol/L vs.(1.6±0.8) mmol/L，P<0.05〕均具有统计学意义。多因素Logistic分析回归分析显示TC、TG偏高为原发性高血压并发初发糖尿病危险因素，OR值分别为2.349(95%Cl：2.10-3.308）、1.903（95%Cl:1.508-2.267）；以HbA1c为因变量，体质量指数、TC、TG、低密度脂蛋白胆固醇为自变量行重线性回归分析，HbA1c与TC成正相关，回归方程为：HbA1c=1.309＋1.626×TC，P<0.01。结论 TG、TC水平升高是高血压病并发初发糖尿病患者的危险因素，并且HbA1c与TC呈正相关。

Abstract:

AIM To investigate the correlative factors of hypertension complicated with newly diagnosed diabetes. METHODS A total of 468 patients with hypertension complicated with newly diagnosed type 2 diabetes were selected for study group and 468 patients with simple essential hypertension served as controls. RESULTS Significant differences were found in body mass index ［(28.8±3.9) kg/m2 vs.(25.1±3.2) kg/m2, P<0.05］, HbA1c ［(9.4±1.6)% vs.(6.0±0.4)%, P<0.05］, total cholesterol ［(4.8±1.4) mmol/L vs.(3.2±0.8) mmol/L, P<0.05］ and triglyceride ［(2.2±1.3) mmol/L vs.(1.6±0.8) mmol/L, P<0.05］ between study group and controls. Logistic regression analysis showed that total cholesterol and triglyceride were high risk factors for primary hypertension complicated with newly diagnosed diabetes mellitus OR=2.349 (95%Cl:2.10-3.308), OR=1.903 (95%Cl:1.508-2.267). Multiple linear regression indicated that HbA1c was associated with total cholesterol. CONCLUSION Triglyceride and total cholesterol are the risk factors of hypertension complicated with newly diagnosed diabetes mellitus and HbA1c is positively correlated with total cholesterol.

参考文献/References

[1]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,6(7):447-498.
[2]章玫红.糖化血红蛋白、血糖与血脂关系的探讨[J].糖尿病新世界,2014,19(16):75-75.
[3]Gadi R,Samaha FF.Dyslipidemia in type 2 diabetes mellitus[J].Curr Diab Rep,2007,7(3):228-234.
[4]Khan SR,Ayub N,Nawab S,et al.Triglyceride profile in dyslipidaemia of type 2 diabetes mellitus[J].J Coll Phys Surg Pak,2008,18(5):270-273.
[5]黄文蔚，徐红新，吕永楠，等.高血压合并严重心血管病危险因素和治疗现状及其影响[J].武汉大学学报(医学版),2001,32(3):374-377.

备注/Memo

备注/Memo:

收稿日期：2016-06-30.基金项目：国家自然科学基金项目资助（81200512） 作者简介：刘博，主治医师，博士 Email:liuboxnk@126.com

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更新日期/Last Update: 1900-01-01