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血管重构在高血压中的研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第4期
页码:
474-477
栏目:
综述
出版日期:
2017-02-25

文章信息/Info

Title:
Research progress of vascular remodeling in hypertension
作者:
齐书涵; 张 欣; 尹新华
哈尔滨医科大学附属第一医院心内科，黑龙江 哈尔滨 150001
Author(s):
QI Shu-han;  ZHANG Xin;  YIN Xin-hua
Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China
关键词:
高血压; 血管重构; 骨桥蛋白; Fibulin-3; 血管紧张素转换酶
Keywords:
hypertension;  vascular remodeling;  osteopontin;  Fibulin-3;  angiotensin converting enzyme
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
高血压是脑卒中、心脏疾病的主要危险因素之一。血管是中空器官具有内分泌功能，可以分泌血管紧张素、血管紧张素转换酶等多种因子，参与高血压发病过程。近几年来，血管重构（VR）在高血压的研究更加广泛和深入。因此，对VR的概念、血管内分泌因子与高血压VR的关系作一综述。
Abstract:
Hypertension is a major contributing risk factor for stroke, ischemic cardiac events and overall mortality. Blood vessels as hollow organs have endocrine function, which could secrete angiotensin and angiotensin converting enzyme. Remodeling of large and small arteries alleviates the development and complications of hypertension. The article reviews the definition, some of the mechanisms involved in the vascular remodeling and the role of osteopontin, Fibulin-3 and renin-angiotensin-aldosterone system in the processes.

参考文献/References

[1]Xu J,Shi GP.Vascular wall extracellular matrix proteins and vascular diseases[J].Biochim Biophys Acta,2014,1842(11):2106-2119.
[2]Baumbach GL,Heistad DD.Remodeling of cerebral arterioles in chronic hypertension[J].Hypertension,1989,13(6Pt2):968-972.
[3]Arribas SM,Costa R,Salomone S,et al.Functional reduction and associated cellular rearrangement in SHRSP rat basilar arteries are affected by salt load and calcium antagonist treatment[J].J Cereb Blood Flow Metab,1999,19(5):517-527.
[4]Hai-Yan J,Bei S,Oudit GY,et al.ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression,inflammation and peroxynitrite production[J].Plos One,2012,7(6):e38502.
[5]Seo KW,Lee SJ,Ye BH,et al.Mechanical stretch enhances the expression and activity of osteopontin and MMP-2 via the Akt1/AP-1 pathways in VSMC[J].J Mol Cell Cardiol,2015,85:13-24.
[6]Liu X,Huang X,Chen L,et al.Mechanical stretch promotes matrix metalloproteinase-2 and prolyl-4-hydroxylase α1 production in human aortic smooth muscle cells via Akt-p38 MAPK-JNK signaling[J].Int J Biochem Cell Biol,2015,62:15-23.
[7]Delphine G,Owens GK.Smooth muscle cell phenotypic switching in atherosclerosis[J].Cardiovasc Res,2012,95(2):156-164.
[8]Davis-Dusenbery BN,Wu C,Hata A.Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation[J].Arterioscler Thromb Vasc Biol,2011,31(11):2370-2377.
[9]Scatena M,Liaw L,Giachelli CM.Osteopontin:A Multifunctional Molecule Regulating Chronic Inflammation and Vascular Disease[J].Arterioscler Thromb Vasc Biol,2007,27(11):2302-2309.
[10]Segade F.Molecular evolution of the fibulins:implications on the functionality of the elastic fibulins[J].Gene,2010,464(1-2):17-31.
[11]Ahn KH,Kim T,Hur JY,et al.Relationship between the expression of fibulin-3 and anterior vaginal wall prolapse[J].J Obstet Gynaecol,2012,32(4):362-366.
[12]Lin ZW,Wang Z,Zhu GP,et al.Hypertensive vascular remodeling was inhibited by Xuezhikang through the regulation of Fibulin-3 and MMPs in spontaneously hypertensive rats[J].Int J Clin Exp Med,2015,8(2):2118-2127.
[13]Haruhiko O,Hiroyuki S,Hidekatsu N,et al.Angiotensin II Signal Transduction Through Small GTP-Binding Proteins Mechanism and Significance in Vascular Smooth Muscle Cells[J].Hypertension,2006,48(4):534-540.
[14]Yin G,Chen Y,Berk BC.Angiotensin II signaling pathways mediated by tyrosine kinases[J].Int J Biochem Cell Biol,2003,35(6):780-783.
[15]Dzau VJ.Theodore Cooper Lecture:Tissue angiotensin and pathobiology of vascular disease:A unifying hypothesis[J].Hypertension,2001,37(4):1047-1052.
[16]Schiffrin EL,Touyz RM.From bedside to bench to bedside:role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension[J].Am J Physiol Heart Circ Physiol,2004,287(2):H435-H446.
[17]Armentano RL,Barra JG,Santana DB,et al.Smart damping modulation of carotid wall energetics in human hypertension[J].Hypertension,2006,47(3):384-390.
[18]Kousei O,Masaki M,Hirotomo N,et al.Possible role of angiotensin-converting enzyme 2 and activation of angiotensin II type 2 receptor by angiotensin-(1-7)in improvement of vascular remodeling by angiotensin II type 1 receptor blockade[J].Hypertension,2013,63(3):e53-e59.
[19]Hai-Yan J,Bei S,Oudit GY,et al.ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression,inflammation and peroxynitrite production[J].Plos One,2012,7(6):e38502.
[20]Patel VB,Sreedhar B,Ratnadeep B,et al.Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis[J].Circ Res,2012,110(10):1322-1335.
[21]Patel VB,Jiu-Chang Z,Dong F, et al. Angiotensin-converting enzyme 2 is a critical determinant of angiotensin II-induced loss of vascular smooth muscle cells and adverse vascular remodeling［J］. Hypertension, 2014, 64(1):151-153.
[22]Prasad AM, Morgan DA,Nuno DW,et al.Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function[J].J Am Heart Assoc,2015,4(6):e001949.
[23]Sparks MA,Makhanova NA,Griffiths RC,et al. Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death[J].Hypertension,2013,61(1):166-173.

备注/Memo

备注/Memo:
收稿日期: 2016-01-29.通讯作者：尹新华，教授，主要从事高血压心血管病方向研究 Email：yinxinhua5063@163.com 作者简介：齐书涵，硕士生 Email：522905937@qq.com
更新日期/Last Update: 1900-01-01