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|本期目录/Table of Contents|

血小板/淋巴细胞比值与冠状动脉侧支循环形成的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第5期
页码:
547-551
栏目:
临床研究
出版日期:
2017-03-25

文章信息/Info

Title:
Association between platelet-to-lymphocyte ratio and coronary collateral circulation formation
作者:
李本磊1; 钱 成1; 方 冬2; 王扬淦1
(1.武汉大学中南医院心内科，湖北 武汉430071；
2.华润武钢总医院心内科，湖北 武汉430080)
Author(s):
LI Ben-lei1;  QIAN Cheng1;  FANG Dong2;  WANG Yang-gan1
(1.Department of Cardiology, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei, China；
2.Department of Cardiology, General Hospital of Affiliated Huarun Wuhan Steel Company, Wuhan 430080, Hubei, China)
关键词:
血小板/淋巴细胞比值; 侧支循环; 慢性完全闭塞; 炎症
Keywords:
platelet-to-lymphocyte ratio;  collateral circulation;  chronic total occlusion;  inflammation
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨血小板/淋巴细胞比值（platelet-to-lymphocyte ratio,PLR）与冠状动脉完全闭塞（chronic total occlusion,CTO）患者冠状动脉侧支循环（coronary collateral circulation,CCC）形成的关系。方法 选取经造影确定主要冠状动脉至少1支存在CTO病变的患者137例，根据Rentrop分级标准对患者的CCC情况进行分级，进一步分为CCC形成不良组（Rentrop 0~Ⅰ级,n=57）和CCC形成良好组（Rentrop Ⅱ~Ⅲ级,n=80）。根据患者的血常规结果计算PLR值。结果 两组患者的PLR分别为163±86和108±36，侧支形成不良组的PLR显著高于侧支形成良好组（P<0.01）。多因素Logistic回归分析表明，PLR是影响CCC形成的独立相关因素（OR:1.02,95%CI:1.008~1.032;P<0.01）。经ROC曲线获得的PLR预测CCC形成不良的曲线下面积为0.75(95%CI:0.67~0.84)，与超敏C反应蛋白（hs-CRP)相当；当PLR截点取140.876时，其诊断效率最高，敏感度为61%, 特异度为82%。结论 在CTO患者中，PLR和CCC的形成相关，高PLR水平是预测CCC形成不良的独立相关因素，其预测价值与hs-CRP相当。
Abstract:
AIM To investigate the relationship between the platelet-to-lymphocyte ratio (PLR) and the formation of coronary collateral circulation (CCC) in patients with coronary chronic total occlusion (CTO). METHODS This study included 137 patients who underwent coronary angiograph in our hospital and were diagnosed as chronic total occlusion with at least one major coronary artery involved. The Rentrop grade system was utilized to clarify the collateral vessels as poor CCC (Rentrop 0-1) and good CCC (Rentrop 2-3). PLR was calculated according to the results of routine blood test. RESULTS Of the enrolled patients, 57 were graded into the poor CCC group and 80 into the good CCC group. The PLR value was significantly higher in poor CCC group than in good CCC group (163±86 vs. 108±36, P<0.01). Multivariate logistic regression demonstrated that PLR was an independent predictor for poor CCC (OR: 1.02, 95%CI: 1.008-1.032; P<0.01). The ROC curve yielded an under curve area of 0.75 for PLR to predict impaired CCC formation, with PLR value>140.876 indicating a sensitivity of 61% and a specificity of 82% for predicting CCC. CONCLUSION In patients with CTO, PLR is associated with the CCC formation and high PLR level is an independent predictor for poor CCC.

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备注/Memo

备注/Memo:
收稿日期：2016-10-12.
通讯作者：王扬淦,教授，主要从事心血管疾病研究 Email：ygwang2015@163.com
作者简介：李本磊，硕士生 Email：1243978581@qq.com
更新日期/Last Update: 2017-04-20