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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2017年第5期

页码:

574-578

栏目:

临床研究

出版日期:

2017-03-25

文章信息/Info

Title:

Correlation between serum gamma glutamine transferase and slow/no reflow and its influence on major adverse cardiovascular events in elderly diabetics patients with acute coronary syndrome

作者:

万进东; 周 鹏; 侯霁芯; 梁登攀; 王沛坚

(成都医学院第一附属医院心血管内科、四川省高校衰老与血管稳态重点实验室，四川 成都 610500)

Author(s):

WAN Jin-dong;  ZHOU Peng;  HOU Ji-xin;  LIANG Deng-pan;  WANG Pei-jian

(Department of Cardiology, First Affiliated Hospital, Chengdu Medical College & Key Laboratory of Aging and Vascular Homeostasis, Sichuan Provincial Universities, Chengdu 610500, Sichuan, China)

关键词:

γ谷氨酰胺转肽酶; 2型糖尿病; 急性冠脉综合征; 慢血流-无复流; 主要心血管不良事件

Keywords:

gamma glutamine transferase;  diabetes mellitus type 2;  acute coronary syndrome;  slow/no-flow;  major adverse cardiovascular events

分类号:

R587.1

DOI:

-

文献标识码:

A

摘要:

目的 探讨老年2型糖尿病(T2DM)并发急性冠脉综合征（ACS）患者血清γ谷氨酰胺转肽酶（GGT）水平与经皮冠状动脉介入（PCI）治疗术后冠脉慢血流-无复流的相关性及其对预后的影响。方法 选取188例诊断为ACS并行急诊PCI的老年T2DM患者，根据TIMI血流分级和校正的TIMI血流帧计数（cTFC）方法评价冠脉血流分为正常血流组（156例）和慢血流-无复流组（32例），分析GGT及其他危险因素与冠脉慢血流-无复流的相关性和主要不良心血管事件(MACE)的发生率。结果 慢血流-无复流组的血清GGT水平高于正常血流组〔(49±18) U/L vs.(31±13) U/L，P<0.01〕。相关分析结果显示，血清GGT与冠脉慢血流-无复流呈正相关（r=0.389，P<0.01）。血清GGT与PCI术后冠脉慢血流-无复流、住院期间及术后12个月MACE独立相关（分别OR=1.093，95%CI:1.058~1.129，P<0.01；OR =1.047，95%CI:1.012~1.082，P<0.05及OR=1.058，95%CI:1.028~1.089，P<0.01）。结论 老年T2DM并发ACS患者血清GGT水平与冠脉慢血流-无复流相关，血清GGT可能是预测冠脉风险的评价指标。

Abstract:

AIM To discuss the correlation between serum gamma glutamine transferase (GGT) and slow/no reflow after percutaneous coronary intervention (PCI) in elderly diabetics patients with acute coronary syndrome (ACS) and its influence on major adverse cardiovascular events (MACE). METHODS One hundred and eighty-eight elderly diabetics patients who were diagnosed as having ACS and were treated with PCI were recruited into our study. The patients were divided into two groups based on the Thombolysis in Myocardial Infarction (TIMI) flow classification and corrected TIMI frame count (cTFC): normal coronary flow (NCF) group (n=156) and slow/no reflow group (n=32). The serum level of GGT and other risk factors were measured and MACEs were recorded. RESULTS The serum level of GGT was significantly increased in slow/no reflow group compared with that in NCF group ［(49±18) U/L vs.(31±13) U/L, P<0.01］. The results of correlation analysis showed a positive correlation between GGT level and slow/no reflow (r=0.389, P<0.01). The serum level of GGT on admission was independently associated with slow/no reflow following primary PCI, in-hospital and twelve-month MACEs in elderly diabetics patients with ACS (OR=1.093, 95 CI:1.058-1.129, P<0.01; OR=1.047, 95%CI: 1.012-1.082, P<0.05 and OR=1.058, 95%CI: 1.028-1.089, P<0.01, respectively). CONCLUSION The serum level of GGT is positively associated with slow/no reflow in elderly diabetics patients with ACS and it can be used as a predictor of coronary risk.

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备注/Memo

备注/Memo:

收稿日期：2017-01-15.
基金项目：国家自然科学基金项目资助(81400289)；四川省科技厅应用基础研究计划项目资助(2015JY0275)；四川省科技计划青年基金项目资助(2016JQ0032)；四川省科技厅科技创新苗子工程项目资助（2016070）；四川省卫生计生委科研 项目资助(150047)；四川省教育厅自然科学重点项目资助（16ZA0277）；北京力生心血管健康基金会领航基金项目 资助（LHJJ20157620）
通讯作者：王沛坚，副教授，主要从事心血管及代谢性疾病基础及临床研究 Email:wpjmed@aliyun.com
作者简介：万进东，硕士生 Email：1156713553@qq.com

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更新日期/Last Update: 2017-04-20