我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

哺乳动物心脏再生的机制

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第5期
页码:
617-620
栏目:
综述
出版日期:
2017-03-25

文章信息/Info

Title:
Mechanisms of mammalian cardiac regeneration
作者:
刘 青; 李晶洁
（哈尔滨医科大学附属第一医院心血管内科，黑龙江 哈尔滨 150001）
Author(s):
LIU Qing;  LI Jing-jie
(Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
哺乳动物; 心脏再生; 心肌细胞增殖
Keywords:
mammals;  cardiac regeneration;  cardiomyocyte proliferation
分类号:
R321
DOI:
-
文献标识码:
A
摘要:
成年人心脏损伤后心肌不能再生，成为全球心力衰竭的主要原因。尽管所有成年哺乳动物心脏均缺乏明显的再生能力，但是一些低等脊椎动物心肌终其一生都可再生。新近研究表明，哺乳动物在发育期及出生后不久，心脏存在再生潜力。而且在各种动物模型中，心脏再生的机制非常相似，如损伤后炎症反应、基质沉积和重构、心肌细胞增殖等的发生。为什么成年哺乳动物心脏损伤后形成广泛疤痕而不是再生，是一个至关重要的问题，可以为防治心力衰竭的发生提供新方向。
Abstract:
Adult human’s failure of cardiac regeneration after cardiac injury is the main cause of heart failure. For all the lack of significant cardiac regeneration in all adult mammals, some vertebrates can regenerate myocardium throughout their life. Recent studies have indicated that mammals have cardiac regeneration potential during development and perinatal period. In a variety of animal models, the mechanisms of heart regeneration are similar, such as inflammatory response, matrix deposition and remodeling, and cardiomyocyte proliferation. Understanding why extensive scar forms and regeneration fails after adult mammalian cardiac damage may provide a new therapeutic strategy for heart failure.

参考文献/References

[1]Porrello ER,Olson EN.A neonatal blueprint for cardiac regeneration[J].Stem Cell Res,2014,13(3 Pt B):556-570.
[2]Bergmann O,Zdunek S,Felker A,et al.Dynamics of Cell Generation and Turnover in the Human Heart[J].Cell,2015,161(7):1566-1575.
[3]Porrello ER,Mahmoud AI,Simpson E,et al.Transient regenerative potential of the neonatal mouse heart[J].Science,2011,331(6020):1078-1080.
[4]Drenckhahn JD,Schwarz QP,Gray S,et al.Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development[J].Dev Cell,2008,15(4):521-533.
[5]Macmahon HE.Hyperplasia and Regeneration of the Myocardium in Infants and in Children[J].Am J Pathol,1937,13(5):845-854.
[6]Haubner BJ,Schneider J,Schweigmann U,et al.Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction[J].Circ Res,2016,118(2):216-221.
[7]Porrello ER,Mahmoud AI,Simpson E,et al.Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family[J].Proc Natl Acad Sci U S A,2013,110(1):187-192.
[8]Darehzereshki A,Rubin N,Gamba L,et al.Differential regenerative capacity of neonatal mouse hearts after cryoinjury[J].Dev Biol,2015,399(1):91-99.
[9]Bryant DM,O'Meara CC,Ho NN,et al.A systematic analysis of neonatal mouse heart regeneration after apical resection[J].J Mol Cell Cardiol,2015,79:315-318.
[10]Andersen DC,Ganesalingam S,Jensen CH,et al.Do neonatal mouse hearts regenerate following heart apex resection?[J].Stem Cell Rep,2014,2(4):406-413.
[11]Han C,Nie Y,Lian H,et al.Acute inflammation stimulates a regenerative response in the neonatal mouse heart[J].Cell Res,2015,25(10):1137-1151.
[12]Senyo SE,Steinhauser ML,Pizzimenti CL,et al.Mammalian heart renewal by pre-existing cardiomyocytes[J].Nature,2013,493(7432):433-436.
[13]Hatzistergos KE,Takeuchi LM,Saur D,et al.cKit+ cardiac progenitors of neural crest origin[J].Proc Natl Acad Sci U S A,2015,112(42):13051-13056.
[14]Soonpaa MH,Kim KK,Pajak L,et al.Cardiomyocyte DNA synthesis and binucleation during murine development[J].Am J Physiol,1996,271(5 Pt 2):H2183-2189.
[15]Mollova M,Bersell K,Walsh S,et al.Cardiomyocyte proliferation contributes to heart growth in young humans[J].Proc Natl Acad Sci U S A,2013,110(4):1446-1451.
[16]Cai MX,Shi XC,Chen T,et al.Exercise training activates neuregulin 1/ErbB signaling and promotes cardiac repair in a rat myocardial infarction model[J].Life Sci,2016,149:1-9.
[17]Mahmoud AI,O'Meara CC,Gemberling M,et al.Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration[J].Dev Cell,2015,34(4):387-399.
[18]White IA,Gordon J,Balkan W,et al.Sympathetic Reinnervation Is Required for Mammalian Cardiac Regeneration[J].Circ Res,2015,117(12):990-994.
[19]Lavine KJ,Epelman S,Uchida K,et al.Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart[J].Proc Natl Acad Sci U S A,2014,111(45):16029-16034.
[20]Zangi L,Lui KO,von Gise A,et al.Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction[J].Nat Biotechnol,2013,31(10):898-907.
[21]Aurora AB,Porrello ER,Tan W,et al.Macrophages are required for neonatal heart regeneration[J].J Clin Invest,2014,124(3):1382-1392.
[22]Ieda M,Tsuchihashi T,Ivey KN,et al.Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling[J].Dev Cell,2009,16(2):233-244.
[23]Williams C,Quinn KP,Georgakoudi I,et al.Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro[J].Acta Biomater,2014,10(1):194-204.
[24]Williams C,Sullivan K,Black LD 3rd.Partially Digested Adult Cardiac Extracellular Matrix Promotes Cardiomyocyte Proliferation in Vitro[J].Adv Healthc Mater,2015,4(10):1545-1554.
[25]Lin Z,Zhou P,von Gise A,et al.Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival[J].Circ Res,2015,116(1):35-45.
[26]Heallen T,Zhang M,Wang J,et al.Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size[J].Science,2011,332(6028):458-461.
[27]Mahmoud AI,Kocabas F,Muralidhar SA,et al.Meis1 regulates postnatal cardiomyocyte cell cycle arrest[J].Nature,2013,497(7448):249-253.
[28]Shen X,Soibam B,Benham A,et al.miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification[J].Proc Natl Acad Sci U S A,2016,113(34):9551-9556.

备注/Memo

备注/Memo:
收稿日期：2016-09-27.
通讯作者：李晶洁，主任医师，主要从事心律失常研究 Email：circulation9999@163.com
作者简介：刘青，硕士生 Email：1311825166@qq.com
更新日期/Last Update: 2017-04-20