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|本期目录/Table of Contents|

极化液在脓毒症心肌损伤的应用研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第1期
页码:
117-120
栏目:
综述
出版日期:
2017-10-10

文章信息/Info

Title:
Research in application of glucose-insulin-potassium in sepsis-induced myocardial injury
作者:
姜 静; 朱长亮; 董敬之; 姚立农
（第四军医大学唐都医院重症监护中心，陕西 西安 710038）
Author(s):
JIANG Jing;  ZHU Chang-liang;  DONG Jing-zhi;  YAO Li-nong
(Intensive Care Unit, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shaanxi, China)
关键词:
脓毒症; 心肌损伤; 极化液; 胰岛素
Keywords:
sepsis;  myocardial injury;  glucose-insulin-potassium;  insulin
分类号:
R611.4
DOI:
-
文献标识码:
A
摘要:
脓毒症是由感染引起的的严重威胁生命的危重病之一，极化液在心肌梗死中的心肌保护作用已毋庸置疑，本文就极化液在脓毒症患者的心肌保护作用做一综述。
Abstract:
Sepsis is one of the most serious infections with significant morbidity and mortality. Sepsis results in many physiological and pathophysiological consequences, incluidng a protective effect on glucose-insulin-potassium pathways critically linked to myocardial infarction. This article reviews the protective effect of glucose-insulin-potassium on sepsis-induced myocardial injury.

参考文献/References

[1]Sodi-Pallares D,Testelli MR,Fishleder BL,et al.Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction:a preliminary clinical report[J].Am J Cardiol,1962,2(9):166-181.

[2]Mehta SR,Yusuf S,Díaz R,et al.Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction:the CREATE-ECLA randomized controlled trial[J].JAMA,2005,293(4):437-446.

[3]MacKenzie A.Endothelium-derived vasoactive agents,AT1 receptors and inflammation[J].Pharmacol Ther,2011,131(2):187-203.

[4]Kakihana Y,Ito T,Nakahara M,et al.Sepsis-induced myocardial dysfunction:pathophysiology and management[J].J Intensive Care,2016,4:22.

[5]Rudiger A,Singer M.Mechanisms of sepsis-induced cardiac dysfunction[J].Crit Care Med,2007,35(6):1599-1608.

[6]Sato R,Nasu M. A review of sepsis-induced cardiomyopathy[J].J Intensive Care,2015,3:48.

[7]Bruni FD,Komwatana P,Soulsby ME,et al.Endotoxin and myocardial failure:role of the myofibril and venous return[J].Am J Physiol,1978,235(2):H150-H156.

[8] Cunnion RE,Schaer GL,Parker MM,et al.The coronary circulation in human septic shock[J].Circulation(Baltimore),1986,73(4):637-644.

[9]Fallach R,Shainberg A,Avlas O,et al.Cardiomyocyte Toll-like receptor 4 is in volved in heart dysfunction following septic shock or myocardial ischemia[J].Mol Cell Cardiol,2010,48 (6):1236-1244.

[10]Dhanantwari P,Nadaraj S,Kenessey A,et al.Macrophage migration inhibitory factor induces cardiomyocyte apoptosis[J].Biochem Biophys Res Commun,2008,371(2):298-303.

[11]Sips PY,Irie T,Zou L,et al.Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression[J].Am J Physiol Heart Circ Physiol,2013,304(8):H1134-H1146.

[12]Tavernier B,Garrigue D,Boulle C,et al.Myofilament calcium sensitivity is decreased in skinned cardiac fibres of endotoxin-treated rabbits[J].Cardiovasc Res,1998,38(2):472-479.

[13]刘亚凤,李文强.补体系统的激活对脓毒症心肌病的不利影响[J].中国急救医学,2011,31(7):658-661.

[14]Bartz RR,Suliman HB,Piantadosi CA.Redox mechanisms of cardiomyocyte mitochondrial protection[J].Front Physiol,2015,6:291.

[15]陈昌勤,张召才,严 静.脓毒症和心肌线粒体损伤(综述)[J].中国危重病急救医学,2007,19(10):630-632.

[16]Bronsveld W,van Lambalgen AA,van Velzen D,et al.Myocardial metabolic and morphometric changes during canine endotoxin shock before and after glucose-insulin-potassium[J].Cardiovasc Res,1985,19:455-464.

[17]Tuynman HA,Thijs LG,Straub JP,et al.Effects of glucose-insulin-potassium(GIK)on the position of the oxyhemoglobin dissociation curve,2.3-diphosphoglycerate, and oxygen consumption in canine endotoxin shock[J].J Surg Res,1983,34(3):246-253.

[18]Hinshaw LB,Archer LT,Benjamin B,et al.Effects of glucose or insulin on myocardial performance in endotoxin shock[J].Proc Soc Exp Biol Med,1976,152(4):529-534.

[19]Das UN.Insulin:an endogenous cardioprotector[J].Curr Opin Crit Care,2003,9(5):375-383.

[20]Bronsveld W,van Lambalgen AA,van Velzen D,et al.Myocardial metabolic and morphometric changes during canine endotoxin shock before and after glucose-insulin-potassium[J].Cardiovasc Res,1985,19(8):455-464.

[21]Tuynman HA,Thijs LG,Straub JP,et al.Effects of glucose-insulin-potassium(GIK)on the position of the oxyhemoglobin dissociation curve,2.3-diphosphoglycerate, and oxygen consumption in canine endotoxin shock[J].J Surg Res,1983,34(3):246-253.

[22]Gao F,Gao E,Yue TL,et al.Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase,Akt,and endothelial nitric oxide synthase phosphorylation[J].Circulation,2002,105(12):1497-1502.

[23]Jeschke MG,Einspanier R,Klein D,et al.Insulin attenuates the systemic inflammatory response to thermal trauma[J].Mol Med, 2002, 8(8):443-450.

[24]Rossig L,Haendeler J,Hermann C,et al.Nitric oxide down-regulates MKP-3 mRNA levels:involvement in endothelial cell protection from apoptosis[J].J Biol Chem,2000,275(33):25502-25507.

[25]Kaynar AM,Bakalov V,Laverde SM,et al.Cost of surviving sepsis:a novel model of recovery from sepsis in Drosophila melanogaster[J].Intensive Care Med Exp, 2016, 4(1):4.

[26]Selker HP, Beshansky JR, Sheehan PR, et al. Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes:the IMMEDIATE randomized controlled trial[J].JAMA,2012,307(18):1925-1933.

[27]Das UN.Pyruvate is an endogenous anti-inflammatory and anti-oxidant molecule[J].Med Sci Monit,2006,12(5):RA79-RA84.

[28]Díaz A,Humeres C,González V,et al.Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death[J].Biochem Biophys Res Commun,2015,467(2):451-457.

[29]Jin PY,Zhang HS,Guo XY,et al.Glucose-insulin-potassium therapy in patients with acute coronary syndrome:a meta-analysis of randomized controlled trials[J].BMC Cardiovasc Disord,2014,14:169.

[30]Puskarich MA,Runyon MS,Trzeciak S,et al.Effect of Glucose-Insulin-Potassium Infusion on Mortality in Critical Care Settings:A Systematic Review and Meta-Analysis[J].Clin Pharmacol,2009,49(7):758-767.

[31]Ali-Hassan-Sayegh S,Mirhosseini SJ,Zeriouh M,et al.Safety and efficacy of glucose-insulin-potassium treatment in coronary artery bypass graft surgery and percutaneous coronary intervention[J].Interact Cardiovasc Thorac Surg,2015,21(5):667676.

[32]Mehta SR,Yusuf S,Diaz R,et al.CREATE-ECLA Trial Group Investigators:Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction:the CREATE-ECLA randomized controlled trial[J].JAMA,2005,293(4):437-446.

[33]Meldrum DR, Donnahoo KK. Role of TNF in mediating renal insufficiency following cardiac surgery: evidence of a postbypass cardiorenal syndrome[J].Surg Res,1999,85(2):185-199.

备注/Memo

备注/Memo:
收稿日期：2016-11-06.作者简介：姜静，硕士生 Email:18729373422@163.com
更新日期/Last Update: 1900-01-01