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|本期目录/Table of Contents|

ApoE和SLCO1B1基因多态性与冠心病的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第2期
页码:
150-153
栏目:
临床研究
出版日期:
2018-02-15

文章信息/Info

Title:
Correlation of ApoE and SLCO1B1 gene polymorphisms with coronary heart disease
作者:
王 瑾; 陈 韬; 刘 连; 胡小政; 汪 奇; 郭 军
（解放军总医院心血管内科，北京100853）
Author(s):
WANG Jin;  CHEN Tao;  LIU Lian;  HU Xiao-zheng;  WANG Qi;  GUO Jun
(Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China)
关键词:
ApoE; SLCO1B1; 基因多态性; 冠状动脉疾病
Keywords:
ApoE;  SLCO1B1;  gene polymorphisms;  coronary heart disease
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨人群中ApoE、SLCO1B1 388A>G和521T>C基因多态性与冠心病的关系。方法 采用病例对照研究方法，冠心病组为确诊的冠心病患者827(男586，女241)例，平均年龄（64±12）岁；对照组为健康个体753(男530，女223)例，平均年龄（62±14）岁。通过PCR-荧光探针法对ApoE和SLCO1B1基因多态性进行检测，并统计分析基因多态性与冠心病的关系。结果 ①冠心病组携带E3/4基因型显著高于对照组（P<0.05）；携带￡4等位基因显著高于对照组（P<0.05）。 ②SLCO1B1 388A>G和521T>C的基因型和等位基因频率以及SLCO1B1基因单倍体频率在冠心病组和对照组中无统计学差异。结论 ①ApoE基因￡4等位基因频率上升是冠心病的重要标志。②SLCO1B1 388A>G和521T>C基因多态性位点与冠心病无明显的相关性。
Abstract:
AIM To investigate the association of ApoE and SLCO1B1 gene polymorphisms with coronary heart disease (CHD), and to provide data in the prevention of CHD. METHODS A case-control study was performed in the present investigation. The CHD group consisted of 827 patients of coronary heart disease, including 586 males and 241 females, mean age was (64±12) year; 753 individuals were enrolled as the control group, including 530 males and 223 females, mean age was (62±14) year. The genotypes were detected by PCR- Fluorescence Probing and the association between gene polymorphisms and CHD was statistically analyzed. RESULTS There were significant differences with regard to genotypes distributions and frequencies of genotypes for ApoE between the patients and the controls (P<0.05). There were no significant differences with regard to genotypes distributions and frequencies of genotypes for SLCO1B1 between patients and controls. CONCLUSION The frequency of￡4 genotypes for ApoE is an important indicator of CHD. The gene polymorphisms of SLCO1B1 388A>G and 521T>C might be uncorrelated with CHD.

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备注/Memo

备注/Memo:
收稿日期：2017-06-23.基金项目：国家自然科学基金项目资助（81500290） 通讯作者：郭军，主任医师，主要从事冠状动脉粥样硬化性心脏病研究 Email:guojun301@hotmail.com 作者简介：王瑾，硕士生 Email:nkuwangjin@163.com 共同第一作者：陈韬，主治医师 Email:insulin@163.com
更新日期/Last Update: 1900-01-01